Testicular toxicity in arsenic exposed albino rats: Ameliorative effects of ascorbic acid and α-tocopherol

Biomedicine

Volumn 31, Issue 1, 2011, Pages 53-63

  Dey, Avijit ^a   Bose, Arindam ^b   Mukhopadhyay, Prabir Kr ^a  

^a PRESIDENCY UNIVERSITY   (India)

^b CHOITHRAM HOSPITAL AND RESEARCH CENTRE   (India)

Author keywords

tocopherol; Arsenic; Ascorbic acid; Oxidative stress; Testis

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; ALPHA TOCOPHEROL; ARSENIC TRIOXIDE; ASCORBIC ACID; CATALASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARSENIC POISONING; ARTICLE; BIOACCUMULATION; CELL MOTILITY; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; EXPERIMENTAL RAT; GAMETOGENESIS; HISTOLOGY; MALE; MORPHOMETRICS; NONHUMAN; OXIDATIVE STRESS; RAT; SEMINIFEROUS TUBULE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTICULAR TOXICITY; TESTIS; TESTIS DISEASE;

RATTUS;

EID: 79955686988     PISSN: 09702067     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Clarkson T. Envioron. Health Prospect 1995; 103: 9-12.
2. Roy P, Saha A. Metabolism and toxicity of arsenic: A human carcinogen. Current Sc. Vol 82 No.1, Jan 2002: 38-45. (Pubitemid 135695188)
3. WHO 1997. Arsenic in drinking water and resulting arsenic toxicity in India and Bangladesh: Recommendation for action. http://www.bvsde.paho.org/ bvsacg/i/fulltext/arsewho/arsewho.pdf.
4. Rahman MM, Sengupta KM, Ahamed S, Lodh D, Das B et al. Murshidabad-one of the nine groundwater arsenic-affected districts of West Bengal, India. Part I: Magnitude of contamination and population at risk. Clin. Toxicol. (Phila) 2005; 43: 823-834.
5. Bissen, Frimmel. Arsenic - a Review, Part I: Occurrence, Toxicity, Speciation, Mobility. Acta hydrochim. hydrobiol. 31 (2003); 1: 9-18.
6. Kadirvel R, Sundaram K, Mani S, Samuel S, Elango N and Panneerselvam C. Supplementation of ascorbic acid and α-tocopherol prevents arsenic-induced protein oxidation and DNA damage induced by arsenic in rats. Human and Experimental Toxicology (2007) 26: 939-946. (Pubitemid 351650811)
7. Chattopadhyay S, Paul S, Ghosh D, Debnath J. Effect of dietary co-administration of sodium selenite on sodium arsenite induced ovarian and uterine disorders in mature albino rats. Toxicol. Sc. 2003; 75: 412-422.
8. Sarkar M, Chaudhuri GR, Chattopadhyay A, Biswas NM. Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian J. Androl. 2003 Mar; 5(1): 27-31.
9. Hei TK, Filipic M. Role of oxidative damage in the genotoxicity of arsenic. Free Radical Biol. Med. 2004; 37: 574-581.
10. Ardjmand AR, Zaker F, Alimoghaddam K, Moezzi L. Arsenic trioxide selectively induces apoptosis within the leukemic cells of APL patients with t (15; 16) translocation. Int. J. Pharmacol 2006; 2: 459-462. (Pubitemid 44613218)
11. Barchowsky A, Dudek EJ, Treadwell MD, Wetterhann KE. Arsenic induced oxidant stress and NF Kappa G activation in cultured aortic endothelial cells. Free Radical Biol. Med. 1996; 21: 783-790.
12. Liu SX, Davidson MM, Tang X et al. Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells. Cancer Res. 2005; 65 (8): 3236-3242. (Pubitemid 40524606)
13. Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: an update. Am. J. Reprod. Immunol. 2008; 59: 2-11.
14. Makker K, Agarwal A, Sharma R. Oxidative stress and male infertility. Indian J. Med Res. 129, April 2009: 357-367
15. Sarkar S, Hazra J, Upadhyay SN, Singh RK and Chowdhury AR. Arsenic induced toxicity on testicular tissue of mice. Indian J. Physiol. Pharmacol. 2008; 52 (1): 84-90.
16. Chang SI, Jin B, Youn P, et al. Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis. Toxicol. Appl. Pharmacol. 2007; 218: 196-203.
17. Sohini, Rana SVS. Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat. Indian Journal of Experimental Biology; Vol-45, April 2007: 371-375.
18. Ramanathan, Balakumar, Panneerselvam. Effects of ascorbic acid and α-tocopherol on arsenic induced oxidative stress. Human and Experimental Toxicology, Vol. 21 (2002) No. 12: 675-680.
19. 14C] amino acid into liver proteins of rats. Br. J. Nutr. 1970; 24: 635-640.
20. Mukherjee S, Das D, Darbar D, Mitra C. Dietary intervention affects arsenic generated nitric oxide and reactive oxygen intermediate toxicity in islet cells of rats. Current Science, vol. 85, no. 6, 25 September 2003: 786-793. (Pubitemid 39160446)
21. Jequier AM. Male Infertility. A guide for clinician. Blackwell, pp.64-65.
22. Jequier AM. Male Infertility. A guide for clinician. Blackwell, pp.55-61.
23. Jequier AM. Male Infertility. A guide for clinician. Blackwell, pp.61-63.
24. Slater Ti. Overview of methods used for detecting lipid peroxidation. Method Enzymol 1984; 105: 283-93.
25. Ohkawa H et al. Assay for lipid peroxidation in animal tissues by thioberbutric acid reaction. Anal Biochem 1979; 95: 351-8 (Pubitemid 9194347)
26. Beers RF, Sizer IW. A spectrophotometric method for measuring the break down of hydrogen peroxide by catalase. J Biol Chem 1952; 5: 133-40.
27. Martin JP Jr, Dailey M, Sugarman E. Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys 1987; Jun 255 (2): 329-336.
28. Jana K, Jana S, Samanta PK. Effects of chronic exposure to sodium arsenite on hypothalamo-pituitary-testicular activities in adult rats: possible an estrogenic mode of action. Reproductive Biology and Endocrinology 2006, 4:9.
29. Balakumar BS, Suresh R, Venugopal R. Modulatory effects of ascorbic acid and α-tocopherol on arsenic induced micronuclei formation. International Journal of Pharmacology 2010;6 (5): 676-680.
30. Menzel DB, Rasmussen RE, Lee E, Meacher DM, Said B et al. Human lymphocyte hemeoxygenase-1 as a response biomarker to inorganic arsenic. Toxicology 1998; 250: 653-656. (Pubitemid 28484783)
31. Pompella A, Romani A, Benedetti A, Comporti M. Loss of membrane protein thiols and lipid peroxidation in allyl alcohol hepatotoxicity. Biochem. Pharmacol. 1991; 41: 1255-1259.
32. Claus Schneider. Chemistry and biology of vitamin E. Mol. Nutr. Food Res. 2005; 49: 7-30.
33. Chainy GBN, Samantaray S, Samanta L. Testosterone induced changes in testicular antioxidant system. Andrologie 1997; 29: 343-9. (Pubitemid 27515199)
34. Ahotupa M, Huhtaniemi I. Impaired detoxification of reactive oxygen and consequent oxidative stress in experimentally criptorchid rat testis. Biol Reprod 1992; 46: 1114-8.
35. Burton GW, Joycen A, Ingold KU. Is vitamin E the only lipid soluble, chain breaking antioxidant in human blood plasma and erythrocyte membrane ? Arch. Biochem. Biophys. 1983;221: 281-290.
36. Niki E, Matsuo M. Rates and products of reactions of vitamin E with oxygen radicals in: Vitamin E. In: Health and disease. 1993. Packer L & Fuchs J (eds). NY: Dekker. pp:121-130.
37. Balakumar BS et al. DNA damage by sodium arsenite in experimental rats: ameliorative effects of antioxidant vitamins C and E. Indian Journal of Science and Technology 2010; vol. 3, no. 3 (Mar): 322-327.
38. Ramanathan et al. Ascorbic acid and alpha-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats. Toxicol. Lett. 2005; 156 (2): 297-306.