Arsenic trioxide selectivity induces apoptosis within the leukemic cells of APL patients with t (15;16) translocation

International Journal of Pharmacology

Volumn 2, Issue 4, 2006, Pages 459-462

  Ardjmand, A R ^a   Zaker, F ^b   Alimoghaddam, K ^a   Moezzi, L ^c  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute promyelocytic Leukemia; Apoptosis; Arsenic trioxide; Fas Apol; Floweytometry

Indexed keywords

ARSENIC TRIOXIDE; LIPOCORTIN 5;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CASE REPORT; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DRUG SELECTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA CELL; MALE; PROMYELOCYTIC LEUKEMIA;

EID: 33750289639     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2006.459.462     Document Type: Article

References (13)

1. Antman, K.H., 2001. The history of Arsenic cancer therapy. Oncologist, 6: 1-2.
2. 3+) and other metal ions on acute promyelocytic leukemia cells. Intl. J. Hematol., 65: 179-185.
3. 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood, 88: 1052-1061.
4. Fenaux, P., S. Chevert and A. Gueric et al., 2000. Long term followup confirms the benefit of all-trans retinoic acid in Acute promyelocytic leukemia. Leukemia, 14: 1371-1377.
5. Grignani, F., P.F. Ferrucci, U. Testa et al., 1993. The Acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell, 74: 423-431.
6. 3 exerts dose-dependent dual effects on APL Cells. Blood, 89: 3345-3353.
7. Herault, O., P. Colombat and J. Domenech et al., 1999. A rapid single-laser flow cytometric method for discrimination of early apoptotic cells in a heterogenous cell population. Br. J. Haematol., 104: 530-507.
8. Miller, W.H.J., 2002. Molecular targets of arsenic trioxide in malignant cells. Oncologist, 1: 1-13.
9. Miller, W.H., H.M. Schipper and J.S. Lee et al., 2002. Mechanisms of action of arsenic trioxide. Cancer. Res., 62: 3893-3903.
10. Warrell, R.P.J., H. The and Z.Y. Wang et al., 1993. Acute promyelocytic leukemia. N. Engl. J. Med., 329: 177-189.
11. Yongkui Jing, Jie Dai, M.E. Ruth Chalmers-Redman and G. Willam et al., 1994. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood, pp: 2102-2111.
12. Zhen-Yi, W. and Z. Chen, 2000. Differentiation and apoptosis induction therapy in Acute promyelocytic leukemia. Lancet Oncol., 1: 101-106.
13. Zhu, J., V. Lallemand-Breitenbach and H. The, 2001. Pathways of retinoic acid or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission. Oncogene, 20: 7257-7265.