Intralesional bleomycin injection treatment for vascular birthmarks: A 5-year experience at a single United Kingdom unit

Plastic and Reconstructive Surgery

Volumn 127, Issue 5, 2011, Pages 2031-2044

  Sainsbury, David C G ^a   Kessell, Gareth ^a   Fall, Andrew J ^a   Hampton, Fiona J ^a   Guhan, Anur ^a   Muir, Tobian ^a  

^a JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN;

ARTICLE; BUTTOCK; CASE REPORT; CHILD; CONGENITAL BLOOD VESSEL MALFORMATION; CYSTIC LYMPHANGIOMA; FEMALE; FOLLOW UP; HEMANGIOMA; HUMAN; INFANT; INTRALESIONAL DRUG ADMINISTRATION; LYMPHATIC SYSTEM DISEASE; MALE; NEWBORN; PRESCHOOL CHILD; SKIN TUMOR; TIME; TREATMENT OUTCOME; UNITED KINGDOM;

ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; BUTTOCKS; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; GREAT BRITAIN; HEMANGIOMA; HUMANS; INFANT; INFANT, NEWBORN; INJECTIONS, INTRALESIONAL; LYMPHANGIOMA, CYSTIC; LYMPHATIC ABNORMALITIES; MALE; SKIN NEOPLASMS; TIME FACTORS; TREATMENT OUTCOME; VASCULAR MALFORMATIONS;

EID: 79955675101     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e31820e923c     Document Type: Article

References (105)

1. Umezawa H, Maeda K, Takeuchi T, Okami Y. New antibiotics: Bleomycin A and B. J Antibiot (Tokyo) 1966;19:200-209.
2. Yura J, Hashimoto T, Tsuruga N, Shibata K. Bleomycin treatment for cystic hygroma in children. Nippon Geka Hokan 1977;46:607-614. (Pubitemid 8229832)
3. Tanigawa N, Shimomatsuya T, Takahashi K, et al. Treatment of cystic hygroma and lymphangioma with the use of bleomycin fat emulsion. Cancer (Phila.) 1987;60:741-749. (Pubitemid 17126285)
4. Ogita S, Tsuto T, Deguchi E, Tokiwa K, Yanagihara J, Iwai N. Treatment of lymphangiomas arising around cervico-facial region: Surgery, bleomycin therapy and OK-432 therapy (in Japanese). Nippon Geka Gakkai Zasshi 1989;90:1389-1391.
5. Jiang JP. Local injection of bleomycin A5 in lymphangioma in children: Analysis of 100 cases (in Chinese). Zhonghua Wai Ke Za Zhi 1989;27:741-742, 781.
6. Tanaka K, Inomata Y, Utsunomiya H, et al. Sclerosing therapy with bleomycin emulsion for lymphangioma in children. Pediatr Surg Int. 1990;5:270-273. (Pubitemid 20369122)
7. Zheng QT. Local injection of bleomycin A5 in children with hemangiomas: Analysis of 210 cases (in Chinese). Zhonghua Wai Ke Za Zhi 1991;29:290-291.
8. Okada A, Kubota A, Fukuzawa M, Imura K, Kamata S. Injection of bleomycin as a primary therapy of cystic lymphangioma. J Pediatr Surg. 1992;27:440-443.
9. Orford J, Barker A, Thonell S, King P, Murphy J. Bleomycin therapy for cystic hygroma. J Pediatr Surg. 1995;30:1282-1287. (Pubitemid 26063482)
10. Sung MW, Chang SO, Choi JH, Kim JY. Bleomycin sclerotherapy in patients with congenital lymphatic malformation in the head and neck. Am J Otolaryngol. 1995;16:236-241.
11. Sarihan H, Mocan H, Yildiz K, Abes M, Akyazici R. A new treatment with bleomycin for complicated cutaneous hemangioma in children. Eur J Pediatr Surg. 1997;7:158-162. (Pubitemid 27340021)
12. Kullendorff CM. Efficacy of bleomycin treatment for symptomatic hemangiomas in children. Pediatr Surg Int. 1997; 12:526-528. (Pubitemid 27346081)
13. Qin ZP, Xin ZF, Ren L, Liu XJ, Yao SG, Linyi S. Long-term results of intratumorous bleomycin-A5 injection for head and neck lymphangioma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:139-144.
14. Zhong PQ, Zhi FX, Li R, Xue JL, Shu GY. Long-term results of intratumorous bleomycin-A5 injection for head and neck lymphangioma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:139-144. (Pubitemid 128644701)
15. Zulfiqar MA, Zaleha AM, Zakaria Z, Amin T. The treatment of neck lymphangioma with intralesional injection of bleomycin. Med J Malaysia 1999;54:478-481.
16. Zhong G, Ma Q, Shao Z. Inner-hemangioma ligation and pingyangmycin injection in hemangioma (with 30 cases report) (in Chinese). Zhonghua Zheng Xing Wai Ke Za Zhi 2000;16:133-135.
17. Liu XJ, Qing ZP, Li KL. Treatment of hemangioma in oral and maxillofacial region with intralesional injection of pingyangmycin (in Chinese). Shanghai Kou Qiang Yi Xue 2001; 10:295-298.
18. Gao Q, Wang C, Wen Y. A study of effects of pingyangmycin injection on treatment of lymphangiomas in oral, maxillofacial and cervical regions (in Chinese). Hua Xi Kou Qiang Yi Xue Za Zhi 2002;20:184-186.
19. Sanlialp I, Karnak I, Tanyel FC, Senocak ME, Büyükpamukc ̧u N. Sclerotherapy for lymphangioma in children. Int J Pediatr Otorhinolaryngol. 2003;67:795-800.
20. Muir T, Kirsten M, Fourie P, Dippenaar N, Ionescu GO. Intralesional bleomycin injection (IBI) treatment for hemangiomas and congenital vascular malformations. Pediatr Surg Int. 2004;19:766-773. (Pubitemid 38387457)
21. Mathur NN, Rana I, Bothra R, Dhawan R, Kathuria G, Pradhan T. Bleomycin sclerotherapy in congenital lymphatic and vascular malformations of head and neck. Int J Pediatr Otorhinolaryngol. 2005;69:75-80. (Pubitemid 41583094)
22. Omidvari S, Nezakatgoo N, Ahmadloo N, Mohammadianpanah M, Mosalaei A. Role of intralesional bleomycin in the treatment of complicated hemangiomas: Prospective clinical study. Dermatol Surg. 2005;31:499-501. (Pubitemid 43073183)
23. Baskin D, Tander B, Bankaoǧlu M. Local bleomycin injection in the treatment of lymphangioma. Eur J Pediatr Surg. 2005;15:383-386. (Pubitemid 43067202)
24. Pienaar C, Graham R, Geldenhuys S, Hudson DA. Intralesional bleomycin for the treatment of hemangiomas. Plast Reconstr Surg. 2006;117:221-226. (Pubitemid 44391569)
25. Shou BQ, Shou WD, Yang Z, et al. Intralesional injection of pingyangmycin for treatment of venous-venular malformation in the maxillofacial regions of children: Report of 306 cases (in Chinese). Shanghai Kou Qiang Yi Xue 2006;15:136-139.
26. Huang YD, Chen JF, Xia SW, et al. Intratumor bleomycin-A5 injection under electrolaryngoscope for treatment of large laryngopharyngeal and laryngeal hemangioma. Nan Fang Yi Ke Da Xue Xue Bao 2006;26:492-494.
27. Zhi K, Wen Y, Li L, Ren W. The role of intralesional pingyangmycin in the treatment of venous malformation of facial and maxillary region. Int J Pediatr Otorhinolaryngol. 2008;72:593-597.
28. Chen Y, Li Y, Zhu Q, et al. Fluoroscopic intralesional injection with pingyangmycin lipiodol emulsion for the treatment of orbital venous malformations. AJR Am J Roentgenol. 2008;190:966-971.
29. López-Larraza D, De Luca JC, Bianchi NO. The kinetics of DNA damage by bleomycin in mammalian cells. Mutat Res. 1990;232:57-61. (Pubitemid 20253720)
30. Mulliken JB, Fishman SJ, Burrows PE. Vascular anomalies. Curr Probl Surg. 2000;37:517-584.
31. Kessell G, Panchatsaram S, Kothmann E, et al. General anaesthesia for intralesional bleomycin therapy of vascular malformations: Initial 3 yr experience. Br J Anaesth. 2009; 102:431-432.
32. Goldiner PL, Schweizer O. The hazards of anesthesia and surgery in bleomycin-treated patients. Semin Oncol. 1979;6: 121-124. (Pubitemid 9165996)
33. Sainsbury DC, Kessell G, Guhan A, et al. Unexpected hyperpigmentation following intralesional bleomycin injection. J Plast Reconstr Aesthet Surg. 2009;62:e497-e499.
34. Yamamoto T. Bleomycin and the skin. Br J Dermatol. 2006; 155:869-875. (Pubitemid 44564492)
35. Finn MC, Glowacki J, Mulliken JB. Congenital vascular lesions: Clinical application of a new classification. J Pediatr Surg. 1983;18:894-900. (Pubitemid 14175292)
36. Blum R, Carter SK, Agre K. A clinical review of bleomycin: A new antineoplastic agent. Cancer 1973;31:903-914.
37. Luce JK. Clinical trial of bleomycin in solid tumours and lymphomas. Proc Am Assoc Cancer Res. 1969;10:38.
38. Sikic BI. Pulmonary toxicity of bleomycin. In: Bleomycin Chemotherapy. New York: Academic Press; 1984:247-254.
39. Ugur O, Caner B, Balbay MD, et al. Bleomycin lung toxicity detected by technetium-99m diethylene triamine penta-acetic acid aerosol scintigraphy. Eur J Nucl Med. 1993;20:114-118. (Pubitemid 23075105)
40. Ionescu G, Mabeta P, Dippenaar N, Muir T, Fourie P, Shelver G. Bleomycin plasma spill-over levels in paediatric patients undergoing intralesional injection for the treatment of hemangiomas. S Afr Med J. 2008;98:539-540.
41. Atwa K, Abuhansa S, Shihab Z, Hashaykeh N, Hasan R. Acute pulmonary toxicity following intralesional administration of bleomycin for lymphovenous malformation. Pediatr Pulmonol. 2010;45:192-196.
42. Garzon MC, Lucky AW, Hawrot A, Frieden IJ. Ultrapotent topical corticosteroid treatment of hemangiomas of infancy. J Am Acad Dermatol. 2005;52:281-286.
43. Sloan GM, Reinisch JF, Nichter LS, Saber WL, Lew K, Morwood DT. Intralesional corticosteroid therapy for infantile hemangiomas. Plast Reconstr Surg. 1989;83:459-467.
44. Chowdri NA, Darzi MA, Fazili Z, Iqbal S. Intralesional corticosteroid therapy for childhood cutaneous hemangiomas. Ann Plast Surg. 1994;33:46-51. (Pubitemid 24208676)
45. Gangopadhyay AN, Sinha CK, Gopal SC, Gupta DK, Sahoo SP, Ahmad M. Role of steroid in childhood hemangioma: A 10 years review. Int Surg. 1997;82:49-51. (Pubitemid 27243666)
46. Chen MT, Yeong EK, Horng SY. Intralesional corticosteroid therapy in proliferating head and neck hemangiomas: A review of 155 cases. J Pediatr Surg. 2000;35:420-423. (Pubitemid 30131602)
47. Edgerton MT. The treatment of hemangiomas: With special reference to the role of steroid therapy. Ann Surg. 1976; 183:517-532.
48. Bartoshesky LE, Bull M, Feingold M. Corticosteroid treatment of cutaneous hemangiomas: How effective? A report on 24 children. Clin Pediatr (Phila.) 1978;17:625, 629-638.
49. Enjolras O, Riche MC, Merland JJ, Escande JP. Management of alarming hemangiomas in infancy: A review of 25 cases. Pediatrics 1990;85:491-498. (Pubitemid 20108467)
50. Sadan N, Wolach B. Treatment of hemangiomas of infants with high doses of prednisone. J Pediatr. 1996;128:141-146. (Pubitemid 26028973)
51. Bennett ML, Fleischer AB Jr, Chamlin SL, Frieden IJ. Oral corticosteroid use is effective for cutaneous hemangiomas: An evidence-based evaluation. Arch Dermatol. 2001;137:1208-1213. (Pubitemid 32847844)
52. Boon LM, MacDonald DM, Mulliken JB. Complications of systemic corticosteroid therapy for problematic hemangioma. Plast Reconstr Surg. 1999;104:1616-1623. (Pubitemid 29510480)
53. Metry DW, Hebert AA. Benign cutaneous vascular tumours of infancy: When to worry, what to do. Arch Dermatol. 2000; 136:905-914. (Pubitemid 30604290)
54. Rogers M. Treatment of 'angiomas': A modern commentary. Australas J Dermatol. 2000;41:S89-S91.
55. Weiss AH. Adrenal suppression after corticosteroid injection of periocular hemangiomas. Am J Ophthalmol. 1989; 107:518-522. (Pubitemid 19136626)
56. Shorr N, Seiff SR. Central retinal artery occlusion associated with periocular corticosteroid injection for juvenile hemangioma. Ophthalmic Surg. 1986;14:229-231. (Pubitemid 16117093)
57. Greinwald JH Jr, Burke DK, Bonthius DJ, Bauman NM, Smith RJ. An update on the treatment of hemangiomas in children with interferon alpha-2a. Arch Otolaryngol Head Neck Surg. 1999;125:21-27. (Pubitemid 29074891)
58. Ezekowitz RA, Mulliken JB, Folkman J. Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med. 1992;326:1456-1463.
59. Bauman NM, Burke DK, Smith RJ. Treatment of massive or life-threatening hemangiomas with recombinant alpha(2a)-interferon. Otolaryngol Head Neck Surg. 1997;117:99-110. (Pubitemid 27304879)
60. Tryfonas GI, Tsikopoulos G, Liasidou E, et al. Conservative treatment of hemangiomas in infancy and childhood with interferon-alpha 2a. Pediatr Surg Int. 1998;13:590-593. (Pubitemid 28526183)
61. Grimal I, Duveau E, Enjolras O, Verret JL, Giniès JL. Effectiveness and dangers of interferon-alpha in the treatment of severe hemangiomas in infants (in French). Arch Pediatr. 2000;7:163-167.
62. Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N Engl J Med. 1999;341:173-181. (Pubitemid 29325746)
63. Hohenleutner S, Badur-Ganter E, Landthaler M, Hohenleutner U. Long-term results in the treatment of childhood hemangioma with the flashlamp-pumped pulsed dye laser: An evaluation of 617 cases. Lasers Surg Med. 2001;28:273-277. (Pubitemid 32275297)
64. Batta K, Goodyear HM, Moss C, Williams HC, Hiller L, Waters R. Randomised controlled study of early pulsed dye laser treatment of uncomplicated childhood hemangiomas: Results of a 1-year analysis. Lancet 2002;360:521-527. (Pubitemid 35232105)
65. Scheepers JH, Quaba AA. Does the pulsed tunable dye laser have a role in the management of infantile hemangiomas? Observations based on 3 years' experience. Plast Reconstr Surg. 1995;95:305-312.
66. Stier MF, Glick SA, Hirsch RJ. Laser treatment of pediatric vascular lesions: Port wine stains and hemangiomas. J Am Acad Dermatol. 2008;58:261-285.
67. Ho NT, Lansang P, Pope E. Topical imiquimod in the treatment of infantile hemangiomas: A retrospective study. J Am Acad Dermatol. 2007;56:63-68. (Pubitemid 46016997)
68. Hemal AK, Aron M, Wadhwa SN. Intralesional sclerotherapy in the management of hemangiomas of the glans penis. J Urol. 1998;159:415-417. (Pubitemid 28049245)
69. Savoca G, De Stefani S, Buttazzi L, Trombetta C, Belgrano E. Sclerotherapy of hemangioma of the glans penis. Urology 2000;56:153.
70. O'Donovan JC, Donaldson JS, Morello FP, Pensler JM, Vogelzang RL, Bauer B. Symptomatic hemangiomas and venous malformations in infants, children, and young adults: Treatment with percutaneous injection of sodium tetradecyl sulfate. AJR Am J Roentgenol. 1997;169:723-729.
71. Moore J, Lee M, Garzon M, et al. Effective therapy of a vascular tumor of infancy with vincristine. J Pediatr Surg. 2001;36:1273-1276. (Pubitemid 32705723)
72. Enjolras O, Brevière GM, Roger G, et al. Vincristine treatment for function-and life-threatening infantile hemangioma (in French). Arch Pediatr. 2004;11:99-107. (Pubitemid 38220704)
73. Fawcett SL, Grant I, Hall PN, Kelsall AW, Nicholson JC. Vincristine as a treatment for a large hemangioma threatening vital functions. Br J Plast Surg. 2004;57:168-171. (Pubitemid 38239893)
74. Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taïeb A. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008;358:2649-2651. (Pubitemid 351831393)
75. Arneja JS, Pappas PN, Shwayder TA, et al. Management of complicated facial hemangiomas with beta-blocker (propranolol) therapy. Plast Reconstr Surg. 2010;126:889-895.
76. Holmes WJ, Mishra A, Gorst C, Liew SH. Propranolol as first-line treatment for rapidly proliferating infantile haemangiomas. J Plast Reconstr Aesthet Surg. Epublished ahead of print August 24, 2010.
77. Tan ST, Itinteang T, Leadbitter P. Low-dose propranolol for infantile haemangioma. J Plast Reconstr Aesthet Surg. 2011;64: 292-299.
78. Siegfried EC, Keenan WJ, Al-Jureidini S. More on propranolol for hemangiomas of infancy. N Engl J Med. 2008;359: 2846; author reply 2846-2847.
79. Lawley LP, Siegfried E, Todd JL. Propranolol treatment for hemangioma of infancy: Risks and recommendations. Pediatr Dermatol. 2009;26:610-614.
80. Holland KE, Frieden IJ, Frommelt PC, Mancini AJ, Wyatt D, Drolet BA. Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma. Arch Dermatol. 2010;146:775-778.
81. de Lorimier AA. Sclerotherapy for venous malformations. J Pediatr Surg. 1995;30:188-193; discussion 194.
82. Berenguer B, Burrows PE, Zurakowski D, Mulliken JB. Sclerotherapy of craniofacial venous malformations: Complications and results. Plast Reconstr Surg. 1999;104:1-11; discussion 12-15.
83. Lee BB, Do YS, Byun HS, Choo IW, Kim DI, Huh SH. Advanced management of venous malformation with ethanol sclerotherapy: Mid-term results. J Vasc Surg. 2003;37:533-538. (Pubitemid 36350895)
84. Rimon U, Garniek A, Galili Y, Golan G, Bensaid P, Morag B. Ethanol sclerotherapy of peripheral venous malformations. Eur J Radiol. 2004;52:283-287. (Pubitemid 39491306)
85. Johnson PL, Eckard DA, Brecheisen MA, Girod DA, Tsue TT. Percutaneous ethanol sclerotherapy of venous malformations of the tongue. AJNR Am J Neuroradiol. 2002;23:779-782. (Pubitemid 34525691)
86. Lee CH, Chen SG. Direct percutaneous ethanol instillation for treatment of venous malformation in the face and neck. Br J Plast Surg. 2005;58:1073-1078.
87. Gelbert F, Enjolras O, Deffrenne D, Aymard A, Mounayer C, Merland JJ. Percutaneous sclerotherapy for venous malformation of the lips: A retrospective study of 23 patients. Neuroradiology 2000;42:692-696.
88. Cabrera J, Cabrera J Jr, Garcia-Olmedo MA, Redondo P. Treatment of venous malformations with sclerosant in microfoam form. Arch Dermatol. 2003;139:1409-1416. (Pubitemid 37433130)
89. Siniluoto TM, Svendsen PA, Wikholm GM, Fogdestam I, Edström S. Percutaneous sclerotherapy of venous malformations of the head and neck using sodium tetradecyl sulphate (sotradecol). Scand J Plast Reconstr Surg Hand Surg. 1997;31:145-150.
90. Mason KP, Michna E, Zurakowski D, Koka BV, Burrows PE. Serum ethanol levels in children and adults after ethanol embolization or sclerotherapy for vascular anomalies. Radiology 2000;217:127-132. (Pubitemid 33097588)
91. Lee BB, Kim DI, Huh S, et al. New experiences with absolute ethanol sclerotherapy in the management of a complex form of congenital venous malformation. J Vasc Surg. 2001; 33:764-772. (Pubitemid 33586630)
92. Herbreteau D, Riche MC, Enjolras O, et al. Percutaneous embolization with Ethibloc of lymphatic cystic malformations with a review of the experience in 70 patients. Int Angiol. 1993;12:34-39. (Pubitemid 23217558)
93. Emery PJ, Bailey CM, Evans JN. Cystic hygroma of the head and neck: A review of 37 cases. J Laryngol Otol. 1984;98: 613-619. (Pubitemid 14079021)
94. Adeyemi SD. Management of cystic hygroma of the head and neck in Lagos, Nigeria; a 10-year experience. Int J Pediatr Otorhinolaryngol. 1992;23:245-251.
95. Charabi B, Bretlau P, Bille M, Holmelund M. Cystic hygroma of the head and neck: A long term follow-up of 44 cases. Acta Otolaryngol Suppl. 2000;543:248-250. (Pubitemid 34098637)
96. Kennedy TL, Whitaker M, Pellitteri P, Wood WE. Cystic hygroma/lymphangioma: A rational approach to management. Laryngoscope 2001;111:1929-1937. (Pubitemid 33042106)
97. Okazaki T, Iwatani S, Yanai T, et al. Treatment of lymphangioma in children: Our experience of 128 cases. J Pediatr Surg. 2007;42:386-389. (Pubitemid 46161564)
98. Ogita S, Tsuto T, Nakamura K, Deguchi E, Iwai N. OK-432 in 64 patients with lymphangioma. J Pediatr Surg. 1994;29: 784-785.
99. Smith RJ, Burke DK, Sato Y, Poust RI, Kimura K, Bauman NM. OK-432 therapy for lymphangiomas. Arch Otolaryngol Head Neck Surg. 1996;122:1195-1199. (Pubitemid 26374846)
100. Schmidt B, Schimpl G, Höllwarth ME. OK-432 therapy of lymphangiomas in children. Eur J Pediatr. 1996;155:649-652. (Pubitemid 26232575)
101. Giguère CM, Bauman NM, Sato Y, et al. Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: A prospective multi-institutional trial. Arch Otolaryngol Head Neck Surg. 2002;128:1137-1144. (Pubitemid 35168103)
102. Rautio R, Keski-Nisula L, Laranne J, Laasonen E. Treatment of lymphangiomas with OK-432 (Picibanil). Cardiovasc Intervent Radiol. 2003;26:31-36. (Pubitemid 36919570)
103. Ruiz E Jr, Valera ET, Veríssimo F, Tone LG. OK-432 therapy for lymphangioma in children (in Portuguese). J Pediatr (Rio J.) 2004;80:154-158.
104. Ogita S, Tsuto T, Tokiwa K, Takahashi T. Intracystic injection of OK-432: A new sclerosing therapy for cystic hygroma in children. Br J Surg. 1987;74:690-691. (Pubitemid 17108421)
105. Greinwald JH Jr, Burke DK, Sato Y, et al. Treatment of lymphangiomas in children: An update of Picibanil (OK-432) sclerotherapy. Otolaryngol Head Neck Surg. 1999;121:381-387. (Pubitemid 29471387)