Acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation

Pediatric Pulmonology

Volumn 45, Issue 2, 2010, Pages 192-196

  Atwa, Khalid ^a   Abuhasna, Said ^b,d   Shihab, Zuhair ^b   Hashaykeh, Nidal ^b   Hasan, Rashed ^c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Mercy Children's Hospital   (United States)

^d NONE

Author keywords

Bleomycin; Child; Lymphovenous malformation; Toxicity

Indexed keywords

BLEOMYCIN; ERYTHROMYCIN; METHYLPREDNISOLONE; PENTOXIFYLLINE; SULTAMICILLIN;

ACUTE RESPIRATORY FAILURE; ACUTE TOXICITY; ADD ON THERAPY; ARTERIAL GAS; ARTICLE; BIOPSY; BLOOD VESSEL BIOPSY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL BLOOD VESSEL MALFORMATION; CONVALESCENCE; COUGHING; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DYSPNEA; FEMALE; FEVER; FIBROSING ALVEOLITIS; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOXEMIA; INFANT; LUNG BIOPSY; LUNG INFILTRATE; LUNG TOXICITY; LYMPHATIC SYSTEM DISEASE; LYMPHOVENOUS MALFORMATION; OXYGEN THERAPY; PALLIATIVE THERAPY; PNEUMOMEDIASTINUM; PNEUMOTHORAX; PRIORITY JOURNAL; RESPIRATORY DISTRESS; SUBCUTANEOUS EMPHYSEMA; TERTIARY HEALTH CARE; THORACOSCOPY; THORAX RADIOGRAPHY; THROMBOSIS; TREATMENT OUTCOME; TUBE; UNIVERSITY HOSPITAL;

ADRENAL CORTEX HORMONES; AIRWAY OBSTRUCTION; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; FEMALE; HUMANS; INFANT; INJECTIONS, INTRALESIONAL; LYMPHATIC ABNORMALITIES; PENTOXIFYLLINE; TREATMENT OUTCOME;

EID: 75849130815     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.21139     Document Type: Article

References (19)

1. Umezawa H. Recent studies on biochemistry and action of bleomycin. In: Carter SK, Crooke ST, Umezawa H, editors. Bleomycin. Current status and new developments. New York: Academic Press; 1978. pp 15-20.
2. Jones AW. Bleomycin lung damage: the pathology and nature of the lesion. Br J Dis Chest 1978;72:321-326.
3. White DA, Stover DE. Severe bleomycin-induced pneumonitis. Clinical features and response to corticosteroids. Chest 1984;86: 723-728.
4. Yousem SA, Lifson JD, Colby TV. Chemotherapy induced eosinophilic pneumonia: relation to bleomycin. Chest 1985;88: 103-106.
5. Acevedo JL, Shah RK, Brietzke SE. Nonsurgical therapies for lymphangiomas: a systematic review. Otolaryngol Head Neck Surg 2008;138:418-424.
6. Kim KH, Sung MW, Roh JL, Han MH. Sclerotherapy for congenital lesions in the head and neck. Otolaryngol Head Neck Surg 2004;131:307-316.
7. Keijzer A, Kuenen B. Fatal pulmonary toxicity in testis cancer with bleomycin-containing chemotherapy. J Clin Oncol 2007;25: 3543-3544.
8. Sikdar T, Macvicar D, Husband JE. Pneumomediastinum complicating bleomycin related lung damage. Br J Radiol 1998; 71:1201-1204.
9. Baskin D, Tander B, Bankaoglu M. Local bleomycin injection in the treatment of lymphangioma. Eur J Pediatr Surg 2005;15:383-386.
10. Alberts DS, Chen HSG, Mayersohn M, Perrier D, Moon TE, Gross JF. Bleomycin pharmacokinetics in man: 2. Intracavitary administration. Cancer Chemother Pharmacol 1979;2:127-132.
11. Segel RD, Schiffman FJ. Systemic toxicity following intracavitary administration of bleomycin. Chest 1990;98:507.
12. Sleijfer S. Bleomycin-induced pneumonitis. Chest 2001;617: 624.
13. Kessell G, Panchatsharam S, Kothmann E, Finn P, Fall A, Guhan A, Muir T. General anaesthesia for intralesional bleomycin therapy for vascular malformation: initial 3 yr experience. Br J Anaesth 2009;102:431-432.
14. O'Sullivan JM, Huddart RA, Norman AR, Nichols J, Dearnaley DP, Horwich A. Predicting the risk of bleomycin lung toxicity in patients with germ cell tumors. Ann Oncol 2003; 14:91-96.
15. White DA, Stover DE. Severe bleomycin-induced pneumonitis: clinical features and response to corticosteroids. Chest 1984;86: 723-728.
16. Goffin J, Kreisman H, Sandor V. Bleomycin-induced lung toxicity and pentoxifylline. J Clin Oncol 2001;19:597-598.
17. Entzian P, Zahringer U, Schlaak M, Gerlach C, Galle J, Zabel P. Comparative study on effects of pentoxifylline, prednisolone and colchicines in experimental alveolitis. Int J Immunopharmacol 1998;20:723-735.
18. Kremer S, Breuer R, Lossos IS, Berkman N, Christensen TG, Connor MW, Goldstein RH. Effect of immunomodulation on bleomycin-induced lung injury. Respiration 1999;66:455-462.
19. Berman B, Duncan MR. Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphea skin and their production of collagen, glycosaminoglycans and fibronectin. Br J Dermatol 1990;123:339-346.