Clerodendron glandulosum.Coleb extract prevents in vitro human LDL oxidation and oxidized LDL induced apoptosis in human monocyte derived macrophages

Food and Chemical Toxicology

Volumn 49, Issue 6, 2011, Pages 1195-1202

  Jadeja, Ravirajsinh N ^a   Thounaojam, Menaka C ^a   Devkar, Ranjisinh V ^a   Ramachandran, A V ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Apoptosis; Clerodenron glandulosum.Coleb; LDL oxidation; Macrophage; Oxidative stress

Indexed keywords

CARDIOVASCULAR AGENT; CLERODENDRON GLANDULOSUM EXTRACT; COPPER; LIPOCORTIN 5; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANGIOSPERM; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL CYCLE; CLERODENDRON GLANDULOSUM; CONTROLLED STUDY; DRUG MECHANISM; HEART PROTECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID PEROXIDATION; MACROPHAGE; MONOCYTE; OXIDATION KINETICS; OXIDATIVE STRESS; PHYTOCHEMISTRY;

ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; CLERODENDRUM; HUMANS; LIPID PEROXIDES; LIPOPROTEINS, LDL; MACROPHAGES; MONOCYTES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PLANT EXTRACTS; PROTEIN CARBONYLATION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

CLERODENDRUM;

EID: 79955665037     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2011.02.017     Document Type: Article

References (40)

1. Ahotupa M., Marniemi J., Lehtimäki T., Talvinen K., Raitakari O.T., Vasankari T., Viikari J., Luoma J., Ylä-Herttuala S. Baseline diene conjugation in LDL lipids as a direct measure of in vivo LDL oxidation. Clin. Biochem. 1998, 31:257-261.
2. Asmis R., Begley J.G. Oxidized LDL promotes peroxide-mediated mitochondrial dysfunction and cell death in human macrophages: a caspase-3-independent pathway. Circ. Res. 2003, 92:e20-29.
3. Aviram M., Fuhrman B. Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis. Atherosclerosis 1998, 137:45-50.
4. Berrougui H., Isabelle M., Cherki M., Khalil A. Marrubium vulgare extract inhibits human-LDL oxidation and enhances HDL-mediated cholesterol efflux in THP-1 macrophage. Life Sci. 2006, 80:105-112.
5. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 1978, 52:302-310.
6. Chandler S.F., Dodds J.H. The effect of phosphate, nitrogen, and sucrose on the production of phenolics and solasidine in callus cultures of Solanum laciniatum. Plant Cell Rep. 1993, 2:105-110.
7. Chang C., Yang M., Wen H., Chern J. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J. Food Drug Anal. 2002, 10:178-182.
8. Chang Y.C., Huang K.X., Huang A.C., Ho Y.C., Wang C.J. Hibiscus anthocyanins-rich extract inhibited LDL oxidation and oxLDL-mediated macrophages apoptosis. Food Chem. Toxicol. 2006, 44:1015-1023.
9. Chu C.Y., Lee H.J., Chu C.Y., Yin Y.F., Tseng T.H. Protective effects of leaf extract of Zanthoxylum ailanthoides on oxidation of low-density lipoprotein and accumulation of lipid in differentiated THP-1 cells. Food Chem. Toxicol. 2009, 47:1265-1271.
10. Deb S., Arunachalam A., Das A.K. Indigenous knowledge of Nyishi tribes on traditional agroforestry systems. Indian J. Traditional Knowledge 2009, 8:41-46.
11. Duell P.B., Wheaton D.L., Shultz A., Nguyen H. Inhibition of LDL oxidation by melatonin requires supraphysiologic concentrations. Clin. Chem. 1998, 44:1931-1936.
12. Esterbauer H., Striegl G., Puhl H., Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic. Res. Commun. 1989, 6:67-75.
13. Frankel E.N., Kanner J., German J.B., Parks E., Kinsella J.E. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993, 341:454-457.
14. Ho H., Hsu L., Chan K., Chen H., Wu C., Wang C. Extract from the leaf of nucifera reduced the development of atherosclerosis via inhibition of vascular smooth muscle cell proliferation and migration. Food Chem. Toxicol. 2010, 48:159-168.
15. Hsieh Y., Kuo W., Lin T., Chang H., Lin T., Chen P., Chu P. Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells. J. Agric. Food Chem. 2007, 55:10437-10445.
16. Isner J.M., Kearney M., Bortman S., Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995, 91:2703-2711.
17. Jadeja R.N., Thounaojam M.C., Ansarullah, Devkar R.V., Ramachandran A.V. A preliminary study on hypolipidemic effect of aqueous leaf extract of Clerodendron glandulosum.Coleb. Int. J. Green Pharm. 2009, 3:285-289.
18. Jadeja R., Thounaojam M., Ansarullah, Ramachandran A.V., Devkar R. Phytochemical constituents and free radical scavenging activity of Clerodendron glandulosum.Coleb methanolic extract. J. Compl. Integr. Med. 2009, 6:19.
19. Jadeja R.N., Thounaojam M.C., Ansarullah, Patel V.B., Devkar R.V., Ramachandran A.V. Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats. Pharma Biol. 2010, 48:1312-1319.
20. Jadeja R.N., Thounaojam M.C., Ansarullah, Devkar R.V., Ramachandran A.V. Clerodendron glandulosum.Coleb., Verbenaceae, ameliorates high fat diet-induced alteration in lipid and cholesterol metabolism in rats. Revista Brasileira De Farmacognosia 2010, 20:117-123.
21. Jadeja R.N., Thounaojam M.C., Dandekar D.S., Devkar R.V., Ramachandran A.V. Clerodendron glandulosum.Coleb extract ameliorates high fat diet/fatty acid induced lipotoxicity in experimental models of non-alcoholic steatohepatitis. Food Chem. Toxicol. 2010, 48:3424-3431.
22. Jadeja R.N., Thounaojam M.C., Ansarullah, Jadav S.V., Patel M.D., Patel D.K., Salunke S.P., Padate G.S., Devkar R.V., Ramachandran A.V. Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum.Coleb leaf extract. Human Exp. Toxicol. 2011, 30:63-70.
23. Kala C.P. Ethnomedicinal botany of the Apatani in the eastern Himalayan region of India. J. Ethnobiol. Ethnomed. 2005, 1:11.
24. Kockx M.M. Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects. Arterioscler. Thromb. Vasc. Biol. 1998, 18:1519-1522.
25. Kockxa M.M., Hermanb A.G. Apoptosis in atherosclerosis: beneficial or detrimental?. Cardiovasc. Res. 2000, 45:736-746.
26. Kolodgie F.D., Narula J., Guillo P., Virmani R. Apoptosis in human atherosclerotic plaques. Apoptosis 1999, 4:5-10.
27. Lee M., Chou F., Tseng T., Hsieh M., Lin M., Wang C. Hibiscus protocatechuic acid or esculetin can inhibit oxidative LDL induced by either copper ion or nitric oxide donor. J. Agric. Food Chem. 2002, 50:2130-2136.
28. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
29. Nourooz-Zadeh J., Tajaddini-Sarmadi J., Ling K.L., Wolff S.P. Low-density lipoprotein is the major carrier of lipid hydroperoxides in plasma. Relevance to determination of total plasma lipid hydroperoxide concentrations. Biochem. J. 1996, 1:781-786.
30. Park E.K., Jung H.S., Yang H.I., Yoo M.C., Kim C., Kim K.S. Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflammation Res. 2007, 56:45-50.
31. 2+ homeostasis. Neurosci. Res. 2000, 37:227-236.
32. Pozarowski P., Darzynkiewicz Z. Analysis of cell cycle by flow cytometry. Methods Mol. Biol. 2004, 281:301-312.
33. Reid V.C., Mitchinson M.J. Toxicity of oxidised low density lipoprotein towards mouse peritoneal macrophages in vitro. Atherosclerosis 1993, 98:17-24.
34. Reznick A.Z., Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol. 1994, 233:357-363.
35. Silva J.P., Sardao V.A., Coutinho O.P., Olveira P.J. Nitrogen compounds prevent H9c2 myoblast oxidative stress-induced mitochondrial dysfunction and cell death. Cardiovasc. Toxicol. 2010, 10:51-65.
36. Stachura M., Pierzynowski S.G. Atherosclerosis and mitochondrial dysfunction - possible links. J. Pre-Clin. Clin. Res. 2009, 3:91-94.
37. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 1997, 272:20963-20966.
38. Stoneman V.E.A., Bennett M.R. Apoptosis in atherosclerosis: beneficial or detrimental?. Clin. Sci. 2004, 107:343-354.
39. Tabas I. Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2255-2264.
40. Young I.S., McEneny J. Lipoprotein oxidation and atherosclerosis. Biochem. Soc. Trans. 2001, 29:358-362.