Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum.Coleb leaf extract

Human and Experimental Toxicology

Volumn 30, Issue 1, 2011, Pages 63-70

  Jadeja, Ravirajsinh N ^a   Thounaojam, Menaka C ^a   Ansarullah, ^a   Jadav, Snehal V ^a   Patel, Mitul D ^a   Patel, Dipak K ^a   Salunke, Sunita P ^a   Padate, Geeta S ^a   Devkar, Ranjitsinh V ^a   Ramachandran, A V ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

carbon tetrachloride; Clerodendron glandulosum.Coleb; hepatotoxicity

Indexed keywords

ASCORBIC ACID; BILIRUBIN; CARBON TETRACHLORIDE; CATALASE; CLERODENDRON GLANDULOSUM EXTRACT; GLUTATHIONE; PLANT EXTRACT; PLASMA PROTEIN; SILYMARIN; SUPEROXIDE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC TOXICITY; CLERODENDRON GLANDULOSUM; CONTROLLED STUDY; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HISTOPATHOLOGY; LETHAL DOSE; LIPID PEROXIDATION; LIVER CELL; LIVER FUNCTION; LIVER INJURY; LIVER PROTECTION; MALE; MICROSCOPY; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; RAT; TOXICOLOGY; VERBENACEAE;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE POISONING; CATALASE; CLERODENDRUM; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; LETHAL DOSE 50; LIPID PEROXIDATION; MALE; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TOXICITY TESTS;

CLERODENDRUM; MUS; RATTUS;

EID: 78650215323     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110368420     Document Type: Article

References (38)

1. Obi FO, Omogbai LA, Oriafo OSJ, Ovat OD Effect of a short time post CCl4 treatment interval on rat plasma enzyme levels and percentage mortality. J Appl Sci Environ Mgt 2001 ; 6: 5-8.
2. MasudaY. Learning toxicology from carbon tetrachloride-induced hepatotoxicity. Yakugaku Zasshi 2006 ; 126: 885-899.
3. Brautbar N., Williams IIJ. Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms. Int J Hyg Environ Health 2002 ; 205: 479-491.
4. Brent JA, Rumack BH Role of free radicals in toxic hepatic injury. II. Are free radicals the cause of toxin-induced liver injury? J Toxicol Clin Toxicol 1993 ; 31: 173-196.
5. Mohana Rao GM, Rao CV, Pushpangadan P., Shirwaikar A. Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol 2006 ; 103: 484-490.
6. Chatterjee TK Medicinal plants with hepatoprotective properties. In: Herbal options. 3 rd ed. Calcutta, India: India Books and Allied (P) Ltd, 2000.
7. Calixto JB Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz J Med Biol Res 2000 ; 33: 179-189.
8. Purkayastha J., Subhan CN, Islamb M. Ethnobotany of medicinal plants from Dibru-Saikhowa Biosphere Reserve of Northeast India. Fitoterapia 2005 ; 76: 121-127.
9. Kala CP Ethnomedicinal botany of the Apatani in the Eastern Himalayan region of India. J Ethnobiol Ethnomed 2005 ; 1: 11.
10. Deb S., Arunachalam A., Das AK Indigenous knowledge of Nyishi tribes on traditional agroforestry systems. Ind J Traditional Knowledge 2009 ; 8: 41-46.
11. Jadeja RN, Thounaojam MC, Ansarullah, Devkar RV, Ramachandran AV A preliminary study on hypolipidemic effect of aqueous leaf extract of Clerodendron glandulosum.coleb. Int J Green Pharm 2009 ; 3: 285-289.
12. Jadeja R., Thounaojam M., Ansarullah, Ramachandran AV, Devkar R. Phytochemical constituents and free radical scavenging activity of Clerodendron glandulosum.coleb methanolic extract. J Compl Integr Med 2009 ; 6: 19.
13. Jadeja RN, Thounaojam MC, Ansarullah, Devkar RV, Ramachandran AV Clerodendrum glandulosum.Coleb.-Verbenaceae, ameliorates high fat diet-induced alteration in lipid and cholesterol metabolism in rats. Revista Brasileira de Farmacognosia 2010 ; 20: 117-123.
14. Humphrey SI, McKenna DJ Herbs and breastfeeding. Breastfeeding Abstr 1997 ; 17: 11-12.
15. Seth SD, Sharma B. Medicinal plants in India. Indian J Med Res 2004 ; 120: 9-11.
16. OECD Principles on Good Laboratory Practice, 2001. In: Handbook, Good Laboratory Practice (GLP), Quality. Practices for Regulated non Clinical Research and. Development TDR PRD/GLP/01.2. Accessed on 12 September 2009.
17. Oecd (testing guideline, 407), 1995. Repeat dose 28 days oral toxicity study in rodents; In-Guidance document for the development of OECD guideline for testing of chemicals Environmental monograph No 76 ; http://oecd.org/document/ 30.0.2340,en2647-34377-19166381111,00html
18. Manokaran S., Jaswanth A., Sengottuvelu S., Nandhakumar J., Duraisamy R., Karthikeyan D., et al. Hepatoprotective activity of Aerva lanata Linn. against paracetamol induced hepatotoxicity in rats. Res J Pharm Tech 2008 ; 1: 398-400.
19. Arhoghro EM, Ekpo KE, Anosike EO, Ibeh GO Effect of aqueous extract of bitter leaf (Vernonia Amygdalina Del) on carbon tetrachloride (CCl4) induced liver damage in albino Wistar rats. Eur J Sci Res 2009 ; 26: 122-130.
20. Buege JA, Aust SD Microsomal lipid peroxidation. Methods Enzymol 1978 ; 52: 302-310.
21. Kakkar P., Das B., Viswanathan PN A modified spectrophotometric assay of SOD. Indian J Biochem Biophys 1984 ; 21: 130-132.
22. Sinha KA Colorimetric assay of catalase. Anal Biochem 1972 ; 47: 389-394.
23. Beutler E., Duron O., Kelly BM Improved method for the determination of blood glutathione. J Lab Clin Med 1963 ; 61: 882-888.
24. Lowery OH, Rosenbrough NJ, Farr AI, Randall RJ Protein measurement with the Folin phenol reagent. J Biol Chem 1951 ; 193: 265-275.
25. Roe JH, Küether CA The determination of ascorbic acid in whole blood and urine through 2-4 dinitrophenyl hydrazine derivative of dehydro ascorbic acid. J Biol Chem 1943 ; 147: 399-407.
26. Interagensy Research Animal Committee (IARC). (2004). Recommendation on LD50 testing ; http://dacu.odnih.gov/ARAC/iracld50html/11-30-04. Accessed on 17 September 2009.
27. Curtis JJ, Mortiz M. Serum enzymes derived from liver cell fraction and response to carbon tetrachloride intoxication in rats. Gastroenterol 1972 ; 62: 84-92.
28. Sipes IG, el Sisi AE, Sim WW, Mobley SA, Earnest DL Reactive oxygen species in the progression of CCl4-induced liver injury. Adv Exp Med Biol 1991 ; 283: 489-497.
29. Rajadurai M., Prince PSM. Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: Biochemical and histopathological evidences. Toxicol 2006 ; 228: 259-268. (Pubitemid 44708452)
30. Meister A. Glutathione metabolism and its selective modification. J Biol Chem 1988 ; 263: 17205-17208.
31. Mohanty I., Arya DS, Dinda A., Talwar KK, Joshi S., Gupta SK Mechanisms of cardioprotective effect of Withania somnifera in experimentally induced myocardial infarction. Basic Clin Pharmacol Toxicol 2004 ; 94: 184-190.
32. Frei B., England L., Ames BN Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 1986 ; 86: 6377-6381.
33. Ozturk IC, Ozturk F., Gul M., Ates B., Cetin A. Protective effects of ascorbic acid on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats. Cell Biochem Funct 2009 ; 27: 309-315.
34. Searle AJ, Wilson RL Glutathione peroxidase: effect of superoxide, hydroxyl and bromine free radicals on enzyme activity. Intl J Radiat Biol Relat Stud Phys Chem Med 1980 ; 37: 213-217.
35. Koop DR Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J 1992 ; 6: 724-730.
36. Zeng T., Zhang CL, Song FY, Han XY, Xie KQ The modulatory effects of garlic oil on hepatic cytochrome P450s in mice. Hum Exp Toxicol 2009 ; 28: 777-783.
37. Robak K., Gryglewski RJ Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 1988 ; 37: 837-841.
38. Ramanathan R., Luu KK, Das NP Anti peroxidative action of flavonoids and related products in ground pork (Abstracts). Proceeding of III Int. Symp. on flavonoids in biology and medicine, Singapore, 1989.