Signalling pathway of isophorone diisocyanate-responsive interleukin-8 in airway smooth muscle cells

European Respiratory Journal

Volumn 37, Issue 5, 2011, Pages 1226-1236

  Kuo, P L ^a   Huang, M S ^a,b   Huang, S K ^a,c   Ni, W C ^a   Hung, J Y ^a,b   Ko, Y C ^a   Hung, C H ^a,b   Tsai, Y M ^a,b   Duh, T H ^a   Hsu, Y L ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Interleukin 8; Isophorone diisocyanate; Migration; Occupational asthma; Proliferation; Rnd3

Indexed keywords

FOCAL ADHESION KINASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 8; ISOCYANIC ACID DERIVATIVE; ISOPHORONE DIISOCYANATE; PROTEIN TYROSINE KINASE; RANTES; UNCLASSIFIED DRUG;

AIRWAY REMODELING; APOPTOSIS; ARTICLE; BINDING SITE; BRONCHUS MUCOSA; BRONCHUS MUSCLE; CELL CULTURE; CELL CYCLE PROGRESSION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSKELETON; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION;

BRONCHI; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; ENZYME INHIBITORS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INTERLEUKIN-8; ISOCYANATES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH; PROTO-ONCOGENE PROTEINS C-AKT; RHO GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 79955664927     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00192109     Document Type: Article

References (26)

1. Farraj AK, Boykin E, Haykal-Coates N, et al. Th2 cytokines in skin draining lymph nodes and serum IgE do not predict airway hypersensitivity to intranasal isocyanate exposure in mice. Toxicol Sci 2007; 100: 99-108. (Pubitemid 47617807)
2. Clarke CW, Aldons PM. Isophorone diisocyanate induced respiratory disease (IPDI). Aust N Z J Med 1981; 11: 290-292. (Pubitemid 11051920)
3. Labrecque M, Khemici E, Cartier A, et al. Impairment in workers with isocyanate-induced occupational asthma and removed from exposure in the province of Québec between 1985 and 2002. J Occup Environ Med 2006; 48: 1093-1098.
4. Lange RW, Lantz RC, Stolz DB, et al. Toluene diisocyanate colocalizes with tubulin on cilia of differentiated human airway epithelial cells. Toxicol Sci 1999; 50: 64-71. (Pubitemid 29344512)
5. Bergeron C, Al-Ramli W, Hamid Q. Remodeling in asthma. Proc Am Thorac Soc 2009; 6: 301-305.
6. Benayoun L, Druilhe A, Dombret MC, et al. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003; 167: 1360-1368. (Pubitemid 36609720)
7. Cohen-Hillel E, Yron I, Meshel T, et al. CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2: cytoskeleton- and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner. Cytokine 2006; 33: 1-16. (Pubitemid 43220346)
8. Bond M, Sala-Newby GB, Newby AC. Focal adhesion kinase (FAK)-dependent regulation of S-phase kinase-associated protein-2 (Skp-2) stability. A novel mechanism regulating smooth muscle cell proliferation. J Biol Chem 2004; 279: 37304-37310. (Pubitemid 39195437)
9. Cohen LA, Guan JL. Mechanisms of focal adhesion kinase regulation. Curr Cancer Drug Targets 2005; 5: 629-643. (Pubitemid 41789601)
10. Fiegen D, Blumenstein L, Stege P, et al. Crystal structure of Rnd3/ RhoE: functional implications. FEBS Lett 2002; 525: 100-104.
11. Klein RM, Aplin AE. Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. Cancer Res 2009; 69: 2224-2233.
12. Klein RM, Spofford LS, Abel EV, et al. B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization. Mol Biol Cell 2008; 19: 498-508. (Pubitemid 351272139)
13. Poch E, Miñambres R, Mocholí E, et al. RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line. Exp Cell Res 2007; 313: 719-31. (Pubitemid 46198817)
14. Fortier M, Comunale F, Kucharczak J, et al. RhoE controls myoblast alignment prior fusion through RhoA and ROCK. Cell Death Differ 2008; 15: 1221-1231. (Pubitemid 351984752)
15. Tliba O, Panettieri RA Jr. Regulation of inflammation by airway smooth muscle. Curr Allergy Asthma Rep 2008; 8: 262-268.
16. Holgate ST. Epithelium dysfunction in asthma. J Allergy Clin Immunol 2007; 120: 1233-1244. (Pubitemid 350225687)
17. Takeda N, Sumi Y, Préfontaine D, et al. Epithelium-derived chemokines induce airway smooth muscle cell migration. Clin Exp Allergy 2009; 39: 1018-1026.
18. Govindaraju V, Michoud MC, Al-Chalabi M, et al. Interleukin-8: novel roles in human airway smooth muscle cell contraction and migration. Am J Physiol Cell Physiol 2006; 291: C957-C965. (Pubitemid 44771814)
19. John AE, Zhu YM, Brightling CE, et al. Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter. J Immunol 2009; 183: 4682-4692.
20. Ogawa H, Inoue S, Ogushi F, et al. Toluene diisocyanate (TDI) nduces production of inflammatory cytokines and chemokines by bronchial epithelial cells via the epidermal growth factor receptor and p38 mitogen-activated protein kinase pathways. Exp Lung Res 2006; 32: 245-262. (Pubitemid 44266715)
21. Lee YM, Kim HA, Park HS, et al. Exposure to toluene diisocyanate (TDI) induces IL-8 production from bronchial epithelial cells: effect of pro-inflammatory cytokines. J Korean Med Sci 2003; 18: 809-812.
22. Lin CL, Zhang ZX, Xu YJ, et al. Focal adhesion kinase antisense oligodeoxynucleotides inhibit human pulmonary artery smooth muscle cells proliferation and promote human pulmonary artery smooth muscle cells apoptosis. Chin Med J (Engl) 2005; 118: 20-26.
23. Li K, Lu Y, Liang J, et al. RhoE enhances multidrug resistance of gastric cancer cells by suppressing Bax. Biochem Biophys Res Commun 2009; 379: 212-216.
24. Ball SG, Shuttleworth CA, Kielty CM. Platelet-derived growth factor receptor-alpha is a key determinant of smooth muscle alpha-actin filaments in bone marrow-derived mesenchymal stem cells. Int J Biochem Cell Biol 2007; 39: 379-391. (Pubitemid 44855658)
25. Foster R, Hu KQ, Lu Y, et al. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol 1996; 16: 2689-2699. (Pubitemid 26161272)
26. Madigan JP, Bodemann BO, Brady DC, et al. Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J 2009; 424: 153-161.