Ochratoxin A exposure assessment of the inhabitants of Lisbon during winter 2007/2008 through bread and urine analysis

Food Additives and Contaminants - Part A

Volumn 26, Issue 10, 2009, Pages 1411-1420

  Duarte, S C ^a   Bento, J M V ^a   Pena, A ^a   Lino, C M ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Bread; Exposure; HPLC; Mycotoxins; Ochratoxin A

Indexed keywords

OCHRATOXIN;

ACCURACY; ADULT; ARTICLE; BREAD; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; FLUOROMETRY; FOOD ANALYSIS; FOOD COMPOSITION; FOOD CONTAMINATION; FOOD INTAKE; FOOD SAFETY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MAIZE; MALE; PORTUGAL; PRIORITY JOURNAL; PUBLIC HEALTH; REPRODUCIBILITY; TOXIN ANALYSIS; URINALYSIS; WINTER;

TRITICUM AESTIVUM; ZEA MAYS;

BREAD; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; FOOD CONTAMINATION; HUMANS; MALE; OCHRATOXINS; PORTUGAL; SEASONS;

EID: 70349433722     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/02652030903107914     Document Type: Article

References (52)

1. Baydar T, Engin AB, Girgin G, Aydin S, Sahin G. 2005. Aflatoxin and ochratoxin in various types of commonly consumed retail ground samples in Ankara, Turkey. Ann Agric Environ Med. 12:193-197.
2. Bento JMV, Pena A, Lino CM, Pereira JA. 2009. Determination of ochratoxin A content in wheat bread samples collected from the Algarve and Bragança regions, Portugal: Winter 2007. Microchem J. 91:165-169.
3. Breitholtz-Emanuelsson A, Minervini F, Hult K, Visconti A. 1994. Ochratoxin A in human serum samples collected in southern Italy from healthy individuals and individuals suffering from different kidney disorders. Natural Toxins. 2:366-370.
4. Caldas ED, Silva SC, Oliveira JN. 2002. Aflatoxinas e ocratoxina A em alimentos e riscos para a saúde humana. Revista Saúde Pública. 36:319-323.
5. Castegnaro M, Plestina R, Dirheimer G, Chernozemsky IN, Bartsch H. 1991. Mycotoxins, endemic nephropathy and urinary tract tumors. IARC Scientific Publications No. 115. Oxford: Oxford University Press.
6. Castegnaro M, Maru V, Maru G, Ruiz-Lopez MD. 1990. High performance liquid chromatography determination of ochratoxin A and its 4R-4-hydroxy metabolite in human urine. Analyst. 115:129-131.
7. Cengiz M, Oruç HH, Uzunoǧlu I, Sonal S. 2007. Ochratoxin A levels in different types of bread and flour. Uludag Univ J Fac Vet Med. 26:7-10.
8. Czerwiecki L, Czajkowska D, Witkowska-Gwiazdowska A. 2002. On ochratoxin A and fungal flora in Polish cereals from conventional and ecological farms. Part 2: Occurrence of ochratoxin A and fungi in cereals in 1998. Food Addit Contam. 19:1051-1057.
9. Dinis AMP, Lino CM, Pena AS. 2007. Ochratoxin A in nephropathic patients from two cities of central zone in Portugal. J Pharm Biomed Anal. 44:553-557.
10. Domijan A-M, Peraica M, Jurjevic Z, Ivic D, Cvjetkovic B. 2005. Fumonisin B1, fumonisin B2, zearalenone and ochratoxin A contamination of maize in Croatia. Food Addit Contam. 22:677-680.
11. EC 2006. Commission Regulation No 401/2006 of 23 February 2006. Laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs. Off J Eur Commun. L70: 12-34.
12. EFSA. 2006. Question no. EFSA-Q-2005-154. Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin A in food. The EFSA J. 365:1-56.
13. Eskola M. 2002. Study on trichothecenes, zearalenone and ochratoxin A in Finnish Cereals: Occurrence and analytical techniques. Academic dissertation, National Veterinary and Food Research Institute (EELA), University of Helsinki, Finland.
14. FAO 2002. Bread wheat: Improvement and production no. 30. Curtis BC. In: Rajaram S, Gómez Macpherson M, editors. FAO Plant Production and Protection Séries. Rome: FAO.
15. Fazekas B, Tar A, Kovács M. 2005. Ochratoxin A content of urine samples of healthy humans in Hungary. Acta Vet Hung. 53:35-44.
16. Gilbert J, Brereton P, MacDonald S. 2001. Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples. Food Addit Contam. 18:1088-1093.
17. Godin M, Francois A, Le Roy F, Morin JP, Creppy EE, Hemet J, Fillastre JP. 1996. Kariomegalic interstitial nephritis. Am J Kid Dis. 27:166-171.
18. González-Osnaya L, Soriano JM, Moltó JC, Mañes J. 2007. Dietary intake of ochratoxin A from conventional and organic bread. Int J Food Microbiol. 118:87-91.
19. International Union of Bakers and Bakers-Confectioners 2008. Available from http://www.world-bread-day.com. Accessed: 21 November 2008.
20. IARC 1993. Some naturally occurring substances, food items and constituents, heterocyclic aromatic amines and mycotoxins. Monograph no. 56. Lyon: International Agency for Research on Cancer.
21. Instituto Português do Consumidor 2005. Available from: http://www.consumidor.pt/loja_novo/includes/content/pao_inf_comp.inc Accessed 8 November 2005.
22. JECFA 2001. Safety evaluation of certain mycotoxins in food. Joint FAO/ WHO Expert Committee on Food Additives. Series No. 47. Available from: http://www.inchem.org/documents/jecfa/jecmono/v47je04.htm. Accessed 2 November 2005.
23. JECFA 2007. Safety evaluations of specific mycotoxins: Ochratoxin A. Prepared by the 56th Meeting of the Joint FAO/WHO Expert Committee on Food Additives, 6-15 February, Geneva.
24. Jonsyn FE. 1999. Intake of aflatoxins and ochratoxins by infants in Sierra Leone: Possible effects on the general health of these children. J Nutr Environ Med. 9:15-22.
25. Jonsyn-Ellis FE. 2000. Seasonal variation in exposure frequency and concentration levels of aflatoxins and ochratoxins in urine samples of boys and girls. Mycopathologia. 152:35-40.
26. Juan C, Pena A, Lino C, Moltó JC, Mañes J. 2008. Levels of ochratoxin A in wheat and maize bread from the central zone of Portugal. Int J Food Microbiol. 127:284-289.
27. Juan C, Lino CM, Pena A, Moltó JC, Mañes J, Silveira I. 2007. Determination of ochratoxin A in maize bread samples by LC with fluorescence detection. Talanta. 73:246-250.
28. Kuiper-Goodman T. 1996. Risk assessment of ochratoxin A: An update. Food Addit Contam. 13:53-57.
29. Laca A, Mousia Z, Díaz M, Webb C, Pandiella SS. 2006. Distribution of microbial contamination within cereal grains. J Food Eng. 72:332-338.
30. Lino CM, Baeta ML, Henri M, Dinis AMP, Pena AS, Silveira MIN. 2008. Levels of ochratoxin A in serum from urban and rural Portuguese populations and estimation of exposure degree. Food Chem Toxicol. 46:879-885.
31. Maaroufi K, Zakhama A, Baudrimont I, Achour A, Abid S, Ellouz F, Dhouib SW, Creppy EE, Bacha H. 1999. Karyomegaly of tubular cells as early stage marker of the nephrotoxicity induced by ochratoxin A in rats. Hum Exp Toxicol. 18:410-415.
32. Machinski Jr M, Soares LMV, Sawazaki E, Bolonhezi D, Castro JL, Bortolleto N. 2001. Aflatoxins, ochratoxin A and zearalenone in Brazilian corn cultivars. J Sci Food Agric. 81:1001-1007.
33. Malir F, Roubal T, Brndiar M, Osterreicher J, Severa J, Knizek H, Kacerovsky J, Tmejova M, Bebeder AM, Baudrimont I, et al. 2001. Ochratoxin A in the Czech Republic. J Toxicol Toxin Rev. 20:261-274.
34. Manique R, Pena A, Lino CM, Moltó JC, Mañes J. 2008. Ochratoxin A in the morning and afternoon portions of urine from Coimbra and Valencian populations. Toxicon. 51:1281- 1287.
35. Miraglia M, and Brera C. 2002. Assessment of dietary intake of ochratoxin A by the population of EU member states. SCOOP/2002. Task 3.2.7. Brussels: European Union.
36. Nikolov IG, Chernozemsky IN, Petkova-Bocharova T, Vrabcheva T, Stojchev I, Bankov B, Castegnaro M, Pfohl-Leszkowicz A, Dragacci S, Day N, et al. 2002. Review of the cooperative studies of the national oncological centre in Bulgaria on Balkan endemic nephropathy and associated urinary tract tumors (1991-2001). Facta Universitatis Ser. Med Biol. 9:119-122.
37. Nordic Working Group on Food Toxicology and Risk Evaluation 1991. Health Evaluation of ochratoxin A in food products. Nordic Seminar and Work Report 545. Copenhagen, Denmark: Nordic Council of Ministers.
38. Pacin AM, Bovier Ciancio, Motta EV, Resnik E, Villa SL, Olsen DM. 2008. Survey of Argentinean human plasma for ochratoxin A. Food Addit Contam. 25:635-641.
39. Palermo D, Pietrobono P, Palermo C, Rotunno T. 2002. Occurrence of ochratoxin A in cereals from Puglia (Italy). Ital J Food Sci. 14:447-453.
40. Paolo OD, Tosi EA. 1998. Contaminacion de harina de maiz con ochratoxina A, aflatoxina y zearalenona. Alimentaria. 293:67-69.
41. Pascale M, Visconti A. 2001. Rapid method for the determination of ochratoxin A in urine by immunoaffinity column clean-up and high-performance liquid chromatography. Mycopathologia. 152:91-95.
42. Pena A, Seifrtová M, Lino CM, Silveira MIN, Solich P. 2006. Estimation of ochratoxin A in Portuguese population: New data on the occurrence in human urine by high performance liquid chromatography with fluorescence detection. Food Chem Toxicol. 4:1449-1454.
43. Petkova-Bocharova T, Castegnaro M, Pfohl-Leszkowicz A, Garren L, Grosso F, Nikolov I, Vrabcheva T, Dragacci S, Chernozemsky IN. 2003. Analysis of ochratoxin A in serum and urine of inhabitants from an area with Balkan endemic nephropathy: A one month follow up study. Facta Universitatis. 10:62-68.
44. Puntaric D, Bosnir J, Smit Z, Skes I, Baklaic Z. 2001. Ochratoxin A in corn and wheat: Geographical association with endemic nephropathy. Croat. Med J. 42:175-180.
45. Sangare-Tigori B, Moukha S, Kouadio HJ, Betbeder A-M, Dano DS, Creppy EE. 2006a. Co-occurrence of aflatoxin B1, fumonisin B1, ochratoxin A and zearalenone in cereals and peanuts from Cǒte d'Ivoire. Food Addit Contam. 23:1000-1007.
46. Sangare-Tigori B, Dem AA, Kouadio HJ, Betbeder A-M, Dano DS, Moukha S, Creppy EE. 2006b. Preliminary survey of ochratoxin A in millet, maize, rice and peanuts in Cǒte d'Ivoire from 1998 to 2002. Hum Exp Toxicol. 25:211-216.
47. SCF 1998. EC report, Opinion on ochratoxin A, expressed on 17 September 1998. Scientific Committee on Food. Schilter B, Marin-Kuan M, Delatour T, Nestler S, Mantle P, Cavin C. 2005. Ochratoxin A: Potential epigenetic mechanisms of toxicity and Carcinogenicity. Food Addit Contam Suppl. 1:88-93.
48. Scott PM. 2005. Biomarkers of human exposure to ochratoxin A. Food Addit Contam Suppl. 1:99-107.
49. Scudamore KA, Banks J, Guy RC. 2003. Fate of ochratoxin A in the processing of whole wheat grains during extrusion. Food Addit Contam. 21:488-497.
50. Sekiyama BL, Ribeiro AB, Machinski PA, Júnior MM. 2005. Aflatoxins, ochratoxin A and zearalenone in maize-based food products. Braz J Microbiol. 36:289-294.
51. Vrabcheva T, Usleber E, Dietrich R, Martlbauer E. 2000. Co-occurrence of ochratoxin A and citrinin in cereals from Bulgarian villages with a history of Balkan endemic nephropathy. J Agric Food Chem. 48:2483-2488.
52. Zummo N, Scott GE. 1992. Interaction of Fusarium moniliforme and Aspergillus flavus on kernel infection and aflatoxin contamination in maize ears. Plant Dis. 76:771-773.