Bone cell activity responsive drug release from biodegradable apatite/collagen nano-composite cements-In vitro dissolution medium responsive vitamin K2 release

Colloids and Surfaces B: Biointerfaces

Volumn 85, Issue 2, 2011, Pages 338-342

  Otsuka, Makoto ^a   Hirano, Ryuhei ^b  

^a MUSASHINO UNIVERSITY   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Dissolution medium responsive drug release; Drug delivery system; Menatetrenone; Self setting apatite collagen composite

Indexed keywords

ACETATE BUFFERS; BONE CELLS; BOVINE COLLAGEN; BULK POWDERS; COMPOSITE CEMENTS; DRUG DELIVERY SYSTEM; DRUG RELEASE; FIXED BLOCK; FOURIER; IN-VITRO; IN-VITRO DISSOLUTION; MACRO PORES; MENATETRENONE; NATURAL BONE; SELF-SETTING APATITE/COLLAGEN COMPOSITE; SIMULATED BODY FLUIDS; X-RAY POWDER;

BONE; CEMENTS; DRUG DELIVERY; INFRARED SPECTROSCOPY; NANOCOMPOSITES; PHOSPHATE MINERALS; PHOSPHORIC ACID; X RAY POWDER DIFFRACTION;

DISSOLUTION;

APATITE; COLLAGEN; MENATETRENONE; NANOCOMPOSITE;

ARTICLE; BIODEGRADABLE IMPLANT; BONE CELL; CELL ACTIVITY; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; NANOANALYSIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; X RAY DIFFRACTION;

ANIMALS; APATITES; BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE CEMENTS; COLLAGEN; DRUG DELIVERY SYSTEMS; NANOCOMPOSITES; OSTEOBLASTS; OSTEOCLASTS; POROSITY; RATS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VITAMIN K 2; X-RAY DIFFRACTION;

BOVINAE;

EID: 79955651670     PISSN: 09277765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2011.03.006     Document Type: Article

References (18)

1. Baron R., Vignery A., Horowitz M. Lymphocytes, Macrophages and the Regulation of Bone Remodeling in Bone and Mineral Research. Annual 2 1987, 209-279. Elsevier, Amsterdam. W.A. Peck (Ed.).
2. H. K. Väänänen H. Zhao, M. Mulari, J.M. Halleen, The cell biology of osteoclast function., J Cell Sci., 2000 Feb 2.;113 (Pt 3): 377-81.
3. Mehlishch D.R., Leider A.S., Roberts W.E. Histologic evaluation of the bone/graft interface after mandibular augmentation with hydroxyapatite/purified fibrillar collagen composite implants. Oral Surg. Oral Med. Oral Pathol. 1990, 70:685-692.
4. Du C., Cui F.Z., Zhu X.D., de Groot K. Three dimensional nano-Hap/Collagen matrix loading with osteogenic cells in organ culture. J. Biomed. Mater. Res. B: Appl. Biomater. 1999, 44:407-415.
5. Martins V.C., Gissis G., Ribeiro A.C., Marcantonio E., Bet M.R. The controlled release of antibiotic by hydroxyapatite anionic collagen composites. Atif. Organs 1998, 22:215-221.
6. Miyamoto Y., Ishikawa K., Takechi M., Toh T., Yuasa T., Nagayama M., Suzuki K. Basic properties of calcium phosphate cement containing atelocollagen in its liquid or powder phases. Biomaterials 1998, 19:707-715.
7. Kikuchi M., Itoh S., Ichinose S., Shinomiya K., Tanaka J. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials 2001, 22:1705-1711.
8. Itoh S., Kikuchi M., Koyama Y., Takakuda K., Shinomiya K., Tanaka J. Development of an artificial vertebral body using a novel biomaterial, hydroxyapatite/collagen composite. Biomaterials 2002, 23:3919-3926.
9. Corltz B.R, Ison I.C., Fulmer M.T., Poser R.D., Smith S.T., Van Wagoner M., Ross J., Goldstein S.A., Jupiter J.B., Rosenthal D.I. Skeletal repair by in situ formation of the mineral phase of bone. Sciences 1995, 267:1796-1799.
10. Otsuka M., Nakahigashi Y., Matsuda Y., Fox J.L., Higuchi W.I., Sugiyama Y. A novel skeletal drug delivery system using self-setting calcium phosphate cement VIII: the relationship between in vitro and in vivo drug release from indomethacin containing cement. J. Control. Release 1997, 43:115-122.
11. Kokubo T., Yoshiwara S., Nishimura N., Yamamuro T. Bioactive bone cement based on CaO-SiO2-P2O5 glass. J. Am. Ceram. Soc. 1991, 74:1739-1741.
12. Mclean F., Urist M., Bone R. Fundamentals of the Physiology of Skeletal Tissue 1968, University of Chicago Press, Chicago, p. 119.
13. Eriksen E.F., Mosekilde L. Estrogen and bone. Bone Miner. Res. 1990, 7:273-312.
14. Otsuka M., Yoneoka K., Matsuda Y., Fox J.L., Higuchi W.I., Sugiyama Y.W.I. Oestradiol release from self-setting apatitic bone cement responsive to plasma-calcium level in ovariectomized rats, and its physicochemical mechanism. J. Pharm. Pharmacol. 1997, 49:1182-1188.
15. Otsuka M., Kuninaga T., Otsuka K., Higuchi W.I. Effect of nanostructure on biodegradation behaviors of self-setting apatite/collagen composite cements containing vitamin K2 in rats. J. Biomed. Mater. Res. B: Appl. Biomater. 2006, 79B:176-184.
16. Otsuka M., Nakagawa H., Ito A., Higuchi W.I. Effect of geometrical structure on drug release rate of a three-dimensionally perforated porous apatite/collagen composite cement. J. Pharm. Sci. 2010, 99:286-292.
17. Hamada H., Ohshima H., Ito A., Higuchi W.I., Otsuka M. Effect of geometrical structure on the biodegradation of a three-dimensionally perforated porous apatite/collagen composite bone cell scaffold. Biol. Phram. Bull. 2010, 33:1228-1232.
18. Rehman I., Bonfield W. Characterization of hydroxyapatite and carbonated apatite by photo acoustic FTIR spectroscopy. J. Mater. Med. 1997, 8:1-4.