Oestradiol release from self-setting apatitic bone cement responsive to plasma-calcium level in ovariectomized rats, and its physicochemical mechanism

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 12, 1997, Pages 1182-1188

  Otsuka, Makoto ^a   Yoneoka, Kazuki ^a   Matsuda, Yoshihisa ^a   Fox, Jeffrey L ^c   Higuchi, William I ^c   Sugiyama, Yuichi ^b  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APATITE; BONE CEMENT; ESTRADIOL;

ANIMAL EXPERIMENT; ARTICLE; BODY FLUID; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG RELEASE; ESTRADIOL BLOOD LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE RELEASE; INFRARED SPECTROSCOPY; NONHUMAN; OVARIECTOMY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; VITAMIN D DEFICIENCY; X RAY DIFFRACTION;

EID: 0031450456     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06067.x     Document Type: Article

References (21)

1. Baron, R., Vignery, A., Horowitz, M. (1987) In: Peck, W. A. (ed.) Lymphocytes, Macrophages and the Regulation of Bone Remodelling in Bone and Mineral Research. Vol. 2, Elsevier Amsterdam, pp. 209-279
2. Brown, W. E., Chow, C. L. (1986) A new calcium phosphate. In: Brown, P. W. (ed.) Water-Setting Cement, Cements Research Progress 1986. American Ceramic Society, pp 352-379
3. 3 and calcium to prevent hip fractures in elderly women. New Engl. J. Med. 327: 1637-1642
4. Corltz, B. R., Ison, I. C., Fulmer, M. T., Poser, R. D., Smith, S. T., VanWagoner, M., Ross, J., Goldstein, S. A., Jupiter, J. B., Rosenthal, D. I. (1995) Skeletal repair by in situ formation of the mineral phase of bone. Science 267: 1796-1799
5. Dawson-Hughes, B., Dallal, G. E., Krall, E. A., Sadowski, L., Sahyoun, N., Tannenbaum, S. (1990) A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N. Engl. J. Med. 323: 878-883
6. Eriksen, E. F., Mosekilde, L. (1990) Estrogen and bone. Bone Mineral Res. 7: 273-312
7. Higuchi, T. (1963) Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52: 1145-1149
8. Kitano, M., Ueda, J. (1971) Calcium spectrophotometrical determination by the methylxylenol blue formed a complex. Nippon Kagaku Kaishi 92: 168-170
9. 5 Glass. J. Am. Ceram. Soc. 74: 1739-1741
10. Lee, C. J., Lawler, C. S., Johnson, G. H. (1981) Effects of supplementation of the diets with calcium and calcium-rich foods on bone density of elderly females with osteoporosis. Am. J. Clin. Nutr. 34: 819-823
11. Mclean, F., Urist, M., Bone, R. (1968) Fundamentals of the Physiology of Skeletal Tissue. University of Chicago Press, Chicago, p. 119
12. Okano, T., Kimura, T., Tsugawa, N., Oshio, Y., Teraoka, Y., Kobayashi, T. (1993) Bioavailability of calcium from oyster shell electrolysate and dl-calcium lactate in vitamin D-replete or vitamin D-deficient rats. J. Bone Miner. Met. 11 (Suppl): S23-S32
13. Okano, T., Kimura, T., Tsugawa, N., Fujiwara, M., Yamamoto, M., Kobayashi, T. (1994) Bioavailability of calcium from bovine-bone-marrow calcium (BBMCa) and calcium carbonate in vitamin D-deficient rats. Food Chem. 51: 61-67
14. Otsuka, M., Matsuda, Y., Suwa, Y., Fox, J. L., Higuchi, W. I. (1994a) A novel skeletal drug delivery system using self-setting bioactive calcium phosphate cement 2: physicochemical properties and drug release rate of the cement-containing indomethacin. J. Pharm. Sci. 83: 611-615
15. Otsuka, M., Matsuda, Y., Kokubo, T., Yoshihara, S., Nakamura, T., Yamamuro, T. (1994b) A novel skeletal drug delivery system using self-setting bioactive glass bone cement III: the in vitro drug release from cement containing indomethacin and its physicochemical properties. J. Contr. Rel. 31: 111-119
16. Otsuka, M., Matsuda, Y., Suwa, Y., Fox, J. L., Higuchi, W. I. (1995) A novel skeletal drug delivery system using self-setting calcium phosphate cement 9: effects of the mixing solution volume on anti-cancer drug release from homogeneous drug loaded-cement. J. Pharm. Sci. 84: 733-736
17. Otsuka, M., Yoneoka, K., Matsuda, Y., Fox, J. L., Higuchi, W. I., Sugiyama, Y. (1996) Plasma calcium level-responsive oestradiol release from self-setting apatitic bone cement in ovariectomized rats. Pharm. Sci. 2: 321-323
18. Otsuka, M., Nakahigashi, Y., Matsuda, Y., Fox, J. L., Higuchi, W. I., Sugiyama, Y. (1997) A novel skeletal drug delivery system using self-setting calcium phosphate cement viii: the relationship between in-vitro and in-vivo drug release from indomethacin-containing cement. J. Contr. Rel. 43: 115-122
19. Suda, T., DeLuca, H. F., Tanaka, Y. (1970) Biological activity of 25-hydroxyergocalciferol in rats. J. Nutr. 100: 1049-1052
20. Yamaoka, K., Tanigawara, Y. (1983) Introduction to Pharmacokinetics by Using Microcomputer. Nankodo, Tokyo
21. Yamaoka, K., Tanigawara, Y., Nakagawa, T., Uno, T. (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobiodyn. 4: 879-885