Effect of nanostructure on biodegradation behaviors of self-setting apatite/collagen composite cements containing vitamin K2 in rats

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 79, Issue 1, 2006, Pages 176-184

  Otsuka, Makoto ^a   Kuninaga, Tomoaki ^b   Otsuka, Kuniko ^c   Higuchi, Wiliiam I ^d  

^a MUSASHINO UNIVERSITY   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d UNIVERSITY OF UTAH   (United States)

Author keywords

Apatite collagen interaction; Biocompatibility; Drug delivery system; Electron probe microanalyzer; Menatetrenone; Nanostructure; Self setting apatite cement

Indexed keywords

APATITE CEMENT; COMPOSITE CEMENTS; DRUG DELIVERY SYSTEM; ELECTRON PROBE MICROANALYZER (EPMA); MECHANOCHEMICAL METHOD; MICRORADIOGRAMS;

BIOCOMPATIBILITY; BIODEGRADATION; COMPOSITE MATERIALS; NANOSTRUCTURED MATERIALS; SCANNING ELECTRON MICROSCOPY; VITAMINS;

COLLAGEN;

APATITE; BONE CEMENT; COLLAGEN; FARNOQUINONE; HYDROXYAPATITE; MENATETRENONE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADATION; COMPOSITE MATERIAL; DENSITY; DRUG DELIVERY SYSTEM; ELECTRON PROBE MICROANALYSIS; FEMALE; IMPLANTATION; MICRORADIOGRAPHY; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SCANNING ELECTRON MICROSCOPY; SOFT TISSUE; X RAY DIFFRACTION;

ANIMALS; APATITES; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; COLLAGEN; DRUG DELIVERY SYSTEMS; FEMALE; NANOSTRUCTURES; RATS; RATS, WISTAR; VITAMIN K 2;

EID: 33749175581     PISSN: 00219304     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.30528     Document Type: Article

References (16)

1. Baron R, Vignery A, Horowitz M. Lymphocytes, macrophages and the regulation of bone remodeling. In: Peck WA, editor. Bone and Mineral Research, Annual 2. Amsterdam: Elsevier; 1984. p 209-279.
2. Aoki H. Medical Applications of Hydroxyapatite. Tokyo: Ishiyaku Euro-America; 1994. p 156.
3. Mehlisch DR, Leider AS, Roberts WE. Histologic evaluation of the bone/graft interface after mandibular augmentation with hydroxyapatite/purified fibrillar collagen composite implants. Oral Surg Oral Med Oral Pathol 1990;70:685-692.
4. Du C, Cui FZ, Zhu XD, de Groot K. Three dimensional nanoHAp/collagen matrix loading with osteogenic cells in organ culture. J Biomed Mater Res 1999;44:407-415.
5. Martins VC, Gissis G, Ribeiro AC, Marcantonio E Jr, Bet MR. The controlled release of antibiotic by hydroxyapatite, anionic collagen composites. Artif Organs 1998;22:215-221.
6. Miyamoto Y, Ishikawa K, Takechi M, Toh T, Yuasa T, Nagayama M, Suzuki K. Basic properties of calcium phosphate cement containing atelocollagen in its liquid or powder phases. Biomaterials 1998;19:707-715.
7. Kikuchi M, Itoh S, Ichinose S, Shinomiya K, Tanaka J. Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials 2001;22:1705-1711.
8. Itoh S, Kikuchi M, Koyama Y, Takakuda K, Shinomiya K, Tanaka J. Development of an artificial vertebral body using a novel biomaterial, hydroxyapatite/collagen composite. Biomaterials 2002;23:3919-3926.
9. Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI. A novel skeletal drug delivery system using self-setting calcium phosphate cement. 3. Physicochemical properties and drug release rate of bovine insulin and bovine albumin. J Pharm Sci 1994;83(1):255-258.
10. Brown WE, Chow CL. A new calcium phosphate water-setting cement. In: Brown PW, editor. Cements Research Progress. Westerville, OH: American Ceramic Society; 1986. p 352-379.
11. Corltz BR, Ison IC, Fulmer MT, Poser RD, Smith ST, Van-Wagoner M, Ross J, Goldstein SA, Jupiter JB, Rosenthal DI. Skeletal repair by in situ formation of the mineral phase of bone. Science 1995;267:1796-1799.
12. Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 2000;15(3):515-521.
13. Shiomi S, Nishiguchi S, Kubo S, Tamori A, Habu D, Takeda T, Ochi H. Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. Am J Gastroenterol 2002;97(4):978-981.
14. Crookham J, Dapson R. Hazardous Chemicals in the Histopathology Laboratory, 2nd ed. San Diego, CA: Anatech; 1991.
15. John A, Hong L, Ikada Y, Tabata Y. A trial to prepare biodegradable collagen-hydroxyapatite composites for bone repair. J Biomater Sci Polym Ed 2001;12:689-705.
16. Chhettry A, Wang Z, Hsu J, Fox JL, Baig AA, Barry AM, Zhuang H, Otsuka M, Higuchi WI. Metastable equilibrium solubility distribution of carbonated apatite as function of solution composition. J Colloid Int Sci 1999;218:57-67.