Expression of E-cadherin and α-catenin in a varicocele-induced infertility rat model

Asian Journal of Andrology

Volumn 13, Issue 3, 2011, Pages 470-475

  Ha, Hong Koo ^a   Park, Hyun Jun ^a,b   Park, Nam Cheol ^a,b  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

Author keywords

catenin; blood testis barrier; E cadherin; infertility; varicocele

Indexed keywords

ALPHA CATENIN; FOLLITROPIN; LUTEINIZING HORMONE; REACTIVE OXYGEN METABOLITE; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD TESTIS BARRIER; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE INFERTILITY; NONHUMAN; PROTEIN EXPRESSION; RAT; SEMINIFEROUS TUBULE; TESTIS WEIGHT; VARICOCELE; WESTERN BLOTTING;

ALPHA CATENIN; ANIMALS; BLOOD-TESTIS BARRIER; CADHERINS; INFERTILITY, MALE; MALE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SEMINIFEROUS TUBULES; VARICOCELE;

EID: 79955644343     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1038/aja.2010.94     Document Type: Article

References (34)

1. Gorelick JI, Goldstein M. Loss of fertility in men with varicocele. Fertil Steril 1993;59: 613-6. (Pubitemid 23086322)
2. Fujisawa M, Hiramine C, Tanaka H, Okada H, Arakawa S et al. Decrease inapoptosis of germ cells in the testes of infertilemen with varicocele. World JUrol 1999; 17: 296-300.
3. Hendin BN, Kolettis PN, Sharma RK, Thomas AJ Jr, Agarwal A. Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J Urol 1999; 161: 1831-4. (Pubitemid 29420743)
4. Ku JH, Shim HB, Kim SW, Paick JS. The role of apoptosis in the pathogenesis of varicocele. BJU Int 2005; 96: 1092-6. (Pubitemid 41531420)
5. Naughton CK, Nangia AK, Agarwal A. Pathophysiology of varicoceles in male infertility. Hum Reprod Update 2001; 7: 473-81. (Pubitemid 32827547)
6. Mruk DD, Cheng CY. Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr Rev 2004; 25: 747-806. (Pubitemid 39362296)
7. Wu JC, Gregory CW, De Philip RM. Expression of E-cadherin in immature rat and mousetestis and in rat Sertoli cell cultures. Biol Reprod 1993; 49: 1353-61. (Pubitemid 23342130)
8. Hirano S, Kimoto N, Shimoyama Y, Hirohashi S, Takeichi M. Identificationof a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. Cell 1992; 70: 293-301.
9. Koksal IT, Ishak Y, Usta M, Danisman A, Guntekin E et al. Varicocele-induced testicular dysfunction may be associated with disruption of blood-testis barrier. Arch Androl 2007; 53: 43-8. (Pubitemid 46277767)
10. Lie PP, Xia W, Wang CQ, Mruk DD, Yan HH et al. Dynamin II interacts with the cadherin-and occludin-based protein complexes at the blood-testis barrier in adult rat testes. J Endocrinol 2006; 191: 571-86. (Pubitemid 46210283)
11. Byers SW, Sujarit S, Jegou B, Butz S, Hoschutzky H et al. Cadherins and cadherin-associated molecules in thedevelopingand maturing rattestis. Endocrinology 1994; 134: 630-9. (Pubitemid 24057204)
12. Chung NP, Mruk D, Mo MY, Lee WM, Cheng CY. A 22-amino acid synthetic peptide corresponding to the second extracellular loop of rat occludin perturbs the blood-testis barrier and disrupts spermatogenesis reversibly in vivo. Biol Reprod 2001; 65:1340-51. (Pubitemid 33031490)
13. Grima J, Silvestrini B, Cheng CY. Reversible inhibition of spermatogenesis in rats using a new male contraceptive, 1-(2,4-dichlorobenzyl)- indazole-3-carbohydrazide. Biol Reprod 2001; 64: 1500-8. (Pubitemid 32373073)
14. Takeichi M. Cadherins: a molecular family important in selective cell-cell adhesion. Annu Rev Biochem 1990; 59: 237-52.
15. Christofori G, Semb H. The Role of thecell-adhesion moleculeE- cadherinasatumour-suppressor gene. Trends Biochem Sci 1999; 24: 73-6.
16. Guilford P. E-cadherin downregulation in cancer: fuel on the fire? Mol Med Today 1999; 5: 172-7. (Pubitemid 29279235)
17. Gumbiner BM. Regulation of cadherinad hesive activity. J Cell Biol 2000; 148: 399-404.
18. Rimm DL, Koslov ER, Kebriaei P, Cianci CD, Morrow JS. Alpha 1(E)-catenin is an actin-binding and-bundling protein mediating the attachment of F-actin to the membraneadhesion complex. Proc Natl Acad Sci USA 1995; 92: 8813-7.
19. Huber O, Bierkamp C, Kemler R. Cadherins and catenins in development. Curr Opin Cell Biol 1996; 8: 685-91. (Pubitemid 26381726)
20. Gumbiner BM, Mc Crea PD. Catenins as mediators of the cytoplasmic functions of cadherins. J Cell Sci Suppl 1993; 17: 155-8. (Pubitemid 24041293)
21. Kowalczyk AP, Bornslaeger EA, Norvell SM, Palka HL, Green KJ. Desmosomes: intercellular adhesive junctions specialized for attachment of intermediate filaments. Int Rev Cytol 1999; 185: 237-302. (Pubitemid 129751076)
22. Huber AH, Weis WI. The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell 2001; 105: 391-402. (Pubitemid 32455345)
23. Imamura Y, Itoh M, Maeno Y, Tsukita S, Nagafuchi A. Functional domains of alpha-catenin requiredfor the strongstateof cadherin-basedcelladhesion. J Cell Biol 1999; 144: 1311-22.
24. Cameron DF, Snydle FE, Ross MH, Drylie DM. Ultrastructural alterations in the adluminal testicular compartment in men with varicocele. Fertil Steril 1980; 33: 526-33. (Pubitemid 10068536)
25. Ku JH, Son H, Kwak C, Lee SE, Lee NKet al. Impact of varicoceleon testicular volume inyoungmen: significanceof compensatoryhypertrophy of contralateral testis. J Urol 2002; 168: 1541-4. (Pubitemid 35034187)
26. Awda BJ, Mackenzie-Bell M, Buhr MM. Reactive oxygen species and boar sperm function. Biol Reprod 2009; 81: 553-61.
27. Agarwal A, Allamaneni SS. Sperm DNA damage assessment: a test whose time has come. Fertil Steril 2005; 84: 850-3. (Pubitemid 41414570)
28. Agarwal A, Said TM. Oxidativestress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int 2005; 95: 503-7. (Pubitemid 40311459)
29. Saleh RA, Agarwal A, Sharma RK, Said TM, Sikka SC et al. Evaluationof nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertil Steril 2003; 80: 1431-6. (Pubitemid 37532458)
30. Camoglio FS, Zampieri N, Corroppolo M, Chironi C, Dipaola G et al. Varicocele and retrogradeadrenal metabolites flow. Anex perimental study onrats. Urol Int 2004; 73: 337-42.
31. Hernandez Gifford JA, Hunzicker-Dunn ME, Nilson JH. Conditional deletion of beta-catenin mediated byAmhr2cre in mice causes female infertility. Biol Reprod 2009; 80:1282-92.
32. Golomb J, Vardinon N, Homonnai ZT, Braf Z, Yust I. Demonstration of antispermatozoal antibodies in varicocele-related infertility with an enzyme-linked immunosorbent assay (ELISA). Fertil Steril 1986; 45: 397-402. (Pubitemid 16127167)
33. Shook TE, Nyberg LM, Collins BS, Mathur S. Pathological and immunological effects of surgically induced varicocele in juvenile and adult rats. Am J Reprod Immunol Microbiol 1988; 17: 141-4.
34. Raitsina SS, Kurnosov AV, Iarovaia IM, Gladkova NS, Davydova AI. Autoimmune nature of spermatogenesis disorders in varicocele models in rats. Biull Eksp Biol Med 1979; 87: 44-8.