메뉴 건너뛰기




Volumn 67, Issue 5, 2011, Pages 493-506

Influences on the pharmacokinetics of oxycodone: A multicentre cross-sectional study in 439 adult cancer patients

Author keywords

Cancer population; Drug drug interactions; Metabolites; Oxycodone; Ratios; Serum concentrations

Indexed keywords

ALBUMIN; CYTOCHROME P450 3A4; DRUG METABOLITE; OXYCODONE;

EID: 79955642732     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-010-0948-5     Document Type: Article
Times cited : (56)

References (65)
  • 2
  • 4
    • 0038206633 scopus 로고    scopus 로고
    • Influences on serum concentrations of morphine, M6G and M3G during routine clinical drug monitoring: A prospective survey in 300 adult cancer patients
    • Klepstad P, Dale O, Kaasa S, Zahlsen K, Aamo T, Fayers P, Borchgrevink PC (2003) Influences on serum concentrations of morphine, M6G and M3G during routine clinical drug monitoring: a prospective survey in 300 adult cancer patients. Acta Anaesthesiol Scand 47(6):725-731
    • (2003) Acta Anaesthesiol Scand , vol.47 , Issue.6 , pp. 725-731
    • Klepstad, P.1    Dale, O.2    Kaasa, S.3    Zahlsen, K.4    Aamo, T.5    Fayers, P.6    Borchgrevink, P.C.7
  • 6
    • 0031725902 scopus 로고    scopus 로고
    • Randomized, double-blind, cross-over trial comparing safety and efficacy of oral controlled-release oxycodone with controlled-release morphine in patients with cancer pain
    • Bruera E, Belzile M, Pituskin E, Fainsinger R, Darke A, Harsanyi Z, Babul N, Ford I (1998) Randomized, double-blind, cross-over trial comparing safety and efficacy of oral controlled-release oxycodone with controlled-release morphine in patients with cancer pain. J Clin Oncol 16(10):3222-3229 (Pubitemid 28481615)
    • (1998) Journal of Clinical Oncology , vol.16 , Issue.10 , pp. 3222-3229
    • Bruera, E.1    Belzile, M.2    Pituskin, E.3    Fainsinger, R.4    Darke, A.5    Harsanyi, Z.6    Babul, N.7    Ford, I.8
  • 8
    • 0026492647 scopus 로고
    • Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer
    • Leow KP, Smith MT, Williams B, Cramond T (1992) Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer. Clin Pharmacol Ther 52(5):487-495
    • (1992) Clin Pharmacol Ther , vol.52 , Issue.5 , pp. 487-495
    • Leow, K.P.1    Smith, M.T.2    Williams, B.3    Cramond, T.4
  • 9
    • 0026749081 scopus 로고
    • The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects
    • Poyhia R, Seppala T, Olkkola KT, Kalso E (1992) The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects. Br J Clin Pharmacol 33(6):617-621
    • (1992) Br J Clin Pharmacol , vol.33 , Issue.6 , pp. 617-621
    • Poyhia, R.1    Seppala, T.2    Olkkola, K.T.3    Kalso, E.4
  • 10
    • 0022523086 scopus 로고
    • A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer
    • DOI 10.1016/0304-3959(86)90234-4
    • Gourlay GK, Cherry DA, Cousins MJ (1986) A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer. Pain 25(3):297-312 (Pubitemid 16085474)
    • (1986) Pain , vol.25 , Issue.3 , pp. 297-312
    • Gourlay, G.K.1    Cherry, D.A.2    Cousins, M.J.3
  • 11
    • 0022627065 scopus 로고
    • High-dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral treatment
    • Sawe J (1986) High-dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral treatment. Clin Pharmacokinet 11(2):87-106
    • (1986) Clin Pharmacokinet , vol.11 , Issue.2 , pp. 87-106
    • Sawe, J.1
  • 14
    • 70449503599 scopus 로고    scopus 로고
    • Utilization of pharmacogenomics and therapeutic drug monitoring for opioid pain management
    • Jannetto PJ, Bratanow NC (2009) Utilization of pharmacogenomics and therapeutic drug monitoring for opioid pain management. Pharmacogenomics 10(7):1157-1167
    • (2009) Pharmacogenomics , vol.10 , Issue.7 , pp. 1157-1167
    • Jannetto, P.J.1    Bratanow, N.C.2
  • 18
    • 19444376971 scopus 로고    scopus 로고
    • Drug metabolism and variability among patients in drug response
    • Wilkinson GR (2005) Drug metabolism and variability among patients in drug response. N Engl J Med 352(21):2211-2221
    • (2005) N Engl J Med , vol.352 , Issue.21 , pp. 2211-2221
    • Wilkinson, G.R.1
  • 19
    • 14844363304 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes
    • Ortiz de Montellano PR (ed) 3 edn. Kluwer Academic/Plenum, New York
    • Guengerich FP (2005) Human cytochrome P450 enzymes. In: Ortiz de Montellano PR (ed) Cytochrome P450: structure, mechanism, and biochemistry, 3 edn. Kluwer Academic/Plenum, New York, p 424
    • (2005) Cytochrome P450: Structure, Mechanism, and Biochemistry , pp. 424
    • Guengerich, F.P.1
  • 20
    • 66749123070 scopus 로고    scopus 로고
    • Pharmacokinetic drug interactions of synthetic opiate analgesics
    • Armstrong SC, Wynn GH, Sandson NB (2009) Pharmacokinetic drug interactions of synthetic opiate analgesics. Psychosomatics 50(2):169-176
    • (2009) Psychosomatics , vol.50 , Issue.2 , pp. 169-176
    • Armstrong, S.C.1    Wynn, G.H.2    Sandson, N.B.3
  • 21
    • 67449126864 scopus 로고    scopus 로고
    • Drug-drug interaction in a kidney transplant recipient receiving HIV salvage therapy and tacrolimus
    • Mertz D, Battegay M, Marzolini C, Mayr M (2009) Drug-drug interaction in a kidney transplant recipient receiving HIV salvage therapy and tacrolimus. Am J Kidney Dis 54(1):E1-E4
    • (2009) Am J Kidney Dis , vol.54 , Issue.1
    • Mertz, D.1    Battegay, M.2    Marzolini, C.3    Mayr, M.4
  • 22
    • 0029128720 scopus 로고
    • Gender effects in pharmacokinetics and pharmacodynamics
    • Harris RZ, Benet LZ, Schwartz JB (1995) Gender effects in pharmacokinetics and pharmacodynamics. Drugs 50(2):222-239
    • (1995) Drugs , vol.50 , Issue.2 , pp. 222-239
    • Harris, R.Z.1    Benet, L.Z.2    Schwartz, J.B.3
  • 23
    • 11944274532 scopus 로고    scopus 로고
    • The influence of age and sex on the clearance of cytochrome P450 3A substrates
    • DOI 10.2165/00003088-200544010-00002
    • Cotreau MM, von Moltke LL, Greenblatt DJ (2005) The influence of age and sex on the clearance of cytochrome P450 3A substrates. Clin Pharmacokinet 44(1):33-60 (Pubitemid 40100551)
    • (2005) Clinical Pharmacokinetics , vol.44 , Issue.1 , pp. 33-60
    • Cotreau, M.M.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 24
    • 0037290646 scopus 로고    scopus 로고
    • Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment
    • DOI 10.1016/S0278-6915(02)00209-0, PII S0278691502002090
    • Dorne JL, Walton K, Renwick AG (2003) Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment. Food Chem Toxicol 41(2):201-224 (Pubitemid 35447872)
    • (2003) Food and Chemical Toxicology , vol.41 , Issue.2 , pp. 201-224
    • Dorne, J.L.C.M.1    Walton, K.2    Renwick, A.G.3
  • 25
    • 0023157369 scopus 로고
    • Hepatic drug-metabolizing enzymes in primary and secondary tumors of human liver
    • El Mouelhi M, Didolkar MS, Elias EG, Guengerich FP, Kauffman FC (1987) Hepatic drug-metabolizing enzymes in primary and secondary tumors of human liver. Cancer Res 47(2):460-466 (Pubitemid 17009609)
    • (1987) Cancer Research , vol.47 , Issue.2 , pp. 460-466
    • El, M.M.1    Didolkar, M.S.2    Elias, E.G.3
  • 26
    • 12244275665 scopus 로고    scopus 로고
    • Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases
    • Yang LQ, Li SJ, Cao YF, Man XB, Yu WF, Wang HY, Wu MC (2003) Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases. World J Gastroenterol 9(2):359-363
    • (2003) World J Gastroenterol , vol.9 , Issue.2 , pp. 359-363
    • Yang, L.Q.1    Li, S.J.2    Cao, Y.F.3    Man, X.B.4    Yu, W.F.5    Wang, H.Y.6    Wu, M.C.7
  • 27
    • 38349167330 scopus 로고    scopus 로고
    • CYP2D6 phenotype prediction from genotype: Which system is the best?
    • Kirchheiner J (2008) CYP2D6 phenotype prediction from genotype: which system is the best? Clin Pharmacol Ther 83(2):225-227
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.2 , pp. 225-227
    • Kirchheiner, J.1
  • 28
    • 0742286803 scopus 로고    scopus 로고
    • Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
    • DOI 10.1007/s00210-003-0832-2
    • Zanger UM, Raimundo S, Eichelbaum M (2004) Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol 369(1):23-37 (Pubitemid 38161221)
    • (2004) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.369 , Issue.1 , pp. 23-37
    • Zanger, U.M.1    Raimundo, S.2    Eichelbaum, M.3
  • 29
    • 0030867948 scopus 로고    scopus 로고
    • Pharmacokinetic drug interactions of new antidepressants: A review of the effects on the metabolism of other drugs
    • Richelson E (1997) Pharmacokinetic drug interactions of new antidepressants: a review of the effects on the metabolism of other drugs. Mayo Clin Proc 72(9):835-847
    • (1997) Mayo Clin Proc , vol.72 , Issue.9 , pp. 835-847
    • Richelson, E.1
  • 30
    • 0030935086 scopus 로고    scopus 로고
    • Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
    • Bertz RJ, Granneman GR (1997) Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin Pharmacokinet 32(3):210-258 (Pubitemid 27122521)
    • (1997) Clinical Pharmacokinetics , vol.32 , Issue.3 , pp. 210-258
    • Bertz, R.J.1    Granneman, G.R.2
  • 31
    • 0034855786 scopus 로고    scopus 로고
    • The importance of cytochrome p450 monooxygenase CYP2D6 in palliative medicine
    • DOI 10.1007/s005200000222
    • Davis MP, Homsi J (2001) The importance of cytochrome P450 monooxygenase CYP2D6 in palliative medicine. Support Care Cancer 9(6):442-451 (Pubitemid 32843631)
    • (2001) Supportive Care in Cancer , vol.9 , Issue.6 , pp. 442-451
    • Davis, M.P.1    Homsi, J.2
  • 32
    • 0023238489 scopus 로고
    • Extensive metabolizers of debrisoquine become poor metabolizers during quinidine treatment
    • Brosen K, Gram LF, Haghfelt T, Bertilsson L (1987) Extensive metabolizers of debrisoquine become poor metabolizers during quinidine treatment. Pharmacol Toxicol 60(4):312-314 (Pubitemid 17064154)
    • (1987) Pharmacology and Toxicology , vol.60 , Issue.4 , pp. 312-314
    • Brosen, K.1    Gram, L.F.2    Haghfelt, T.3    Bertilsson, L.4
  • 35
    • 33646183072 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites
    • Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shen DD (2006) Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther 79(5):461-479
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.5 , pp. 461-479
    • Lalovic, B.1    Kharasch, E.2    Hoffer, C.3    Risler, L.4    Liu-Chen, L.Y.5    Shen, D.D.6
  • 36
    • 0031033163 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of controlled-release opioids
    • Kaiko RF (1997) Pharmacokinetics and pharmacodynamics of controlled-release opioids. Acta Anaesthesiol Scand 41(1 Pt 2): 166-174
    • (1997) Acta Anaesthesiol Scand , vol.41 , Issue.1 PART 2 , pp. 166-174
    • Kaiko, R.F.1
  • 37
    • 0030024758 scopus 로고    scopus 로고
    • The pharmacokinetics of oxycodone in uremic patients undergoing renal transplantation
    • DOI 10.1016/0952-8180(95)00092-5
    • Kirvela M, Lindgren L, Seppala T, Olkkola KT (1996) The pharmacokinetics of oxycodone in uremic patients undergoing renal transplantation. J Clin Anesth 8(1):13-18 (Pubitemid 26068222)
    • (1996) Journal of Clinical Anesthesia , vol.8 , Issue.1 , pp. 13-18
    • Kirvela, M.1    Lindgren, L.2    Seppala, T.3    Olkkola, K.T.4
  • 40
    • 74249120678 scopus 로고    scopus 로고
    • Effect of obesity on the pharmacokinetics of drugs in humans
    • Hanley MJ, Abernethy DR, Greenblatt DJ (2010) Effect of obesity on the pharmacokinetics of drugs in humans. Clin Pharmacokinet 49(2):71-87
    • (2010) Clin Pharmacokinet , vol.49 , Issue.2 , pp. 71-87
    • Hanley, M.J.1    Abernethy, D.R.2    Greenblatt, D.J.3
  • 42
    • 84961250245 scopus 로고
    • The use of the nitrogen mustards in the palliative treatment of carcinoma
    • Karnofsky, David A, Abelmann, Walther H, Craver, Lloyd F, Burchenal, Joseph H (1948) The use of the nitrogen mustards in the palliative treatment of carcinoma. Cancer 1(4):634-656
    • (1948) Cancer , vol.1 , Issue.4 , pp. 634-656
    • Karnofsky, D.A.1    Abelmann, W.H.2    Craver, L.F.3    Burchenal, J.H.4
  • 45
    • 79955623545 scopus 로고    scopus 로고
    • Estimating glomerular filtration rate with a new equation: MDRD4revised equation for use with IDMS-traceable serum creatinine
    • Levey AS, Coresh J, Greene T, Marsh J, Kusek J, Van Lente Medicine F (2005) Estimating glomerular filtration rate with a new equation: MDRD4revised equation for use with IDMS-traceable serum creatinine. J Am Soc Nephrol 11[Suppl] :F-FC142
    • (2005) J Am Soc Nephrol , vol.11 , Issue.SUPPL.
    • Levey, A.S.1    Coresh, J.2    Greene, T.3    Marsh, J.4    Kusek, J.5    Van Lente Medicine, F.6
  • 46
    • 78149239835 scopus 로고
    • How many subjects does it take to do a regression analysis?
    • Green SB (1991) How many subjects does it take to do a regression analysis? Multivariate Behav Res 26(3):499-510
    • (1991) Multivariate Behav Res , vol.26 , Issue.3 , pp. 499-510
    • Green, S.B.1
  • 48
    • 33947411705 scopus 로고    scopus 로고
    • Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
    • Edwards SR, SmithMT (2007) Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 848(2):264-270
    • (2007) J Chromatogr B Analyt Technol Biomed Life Sci , vol.848 , Issue.2 , pp. 264-270
    • Edwards, S.R.1    Smith, M.T.2
  • 49
    • 0028936323 scopus 로고
    • Application issues in bioanalytical method validation, sample analysis and data reporting
    • Dadgar D, Burnett PE, Choc MG, Gallicano K, Hooper JW (1995) Application issues in bioanalytical method validation, sample analysis and data reporting. J Pharm Biomed Anal 13 (2):89-97
    • (1995) J Pharm Biomed Anal , vol.13 , Issue.2 , pp. 89-97
    • Dadgar, D.1    Burnett, P.E.2    Choc, M.G.3    Gallicano, K.4    Hooper, J.W.5
  • 51
    • 0031933116 scopus 로고    scopus 로고
    • Systematic review of factors affecting the ratios of morphine and its major metabolites
    • DOI 10.1016/S0304-3959(97)00142-5, PII S0304395997001425
    • Faura CC, Collins SL, Moore RA, McQuay HJ (1998) Systematic review of factors affecting the ratios of morphine and its major metabolites. Pain 74(1):43-53 (Pubitemid 28097728)
    • (1998) Pain , vol.74 , Issue.1 , pp. 43-53
    • Faura, C.C.1    Collins, S.L.2    Moore, R.A.3    McQuay, H.J.4
  • 53
    • 0025219225 scopus 로고
    • Plasma levels of morphine and morphine glucuronides in the treatment of cancer pain: Relationship to renal function and route of administration
    • Peterson GM, Randall CT, Paterson J (1990) Plasma levels of morphine and morphine glucuronides in the treatment of cancer pain: relationship to renal function and route of administration. Eur J Clin Pharmacol 38(2):121-124 (Pubitemid 20097314)
    • (1990) European Journal of Clinical Pharmacology , vol.38 , Issue.2 , pp. 121-124
    • Peterson, G.M.1    Randall, C.T.C.2    Paterson, J.3
  • 54
    • 0242417471 scopus 로고    scopus 로고
    • Gender differences in drug effects: Implications for anesthesiologists
    • DOI 10.1034/j.1399-6576.2003.00036.x
    • Pleym H, Spigset O, Kharasch ED, Dale O (2003) Gender differences in drug effects: implications for anesthesiologists. Acta Anaesthesiol Scand 47(3):241-259 (Pubitemid 36384661)
    • (2003) Acta Anaesthesiologica Scandinavica , vol.47 , Issue.3 , pp. 241-259
    • Pleym, H.1    Spigset, O.2    Kharasch, E.D.3    Dale, O.4
  • 56
    • 0026708362 scopus 로고
    • Effect of age and gender on the activity of human hepatic CYP3A
    • Hunt CM, Westerkam WR, Stave GM (1992) Effect of age and gender on the activity of human hepatic CYP3A. Biochem Pharmacol 44(2):275-283
    • (1992) Biochem Pharmacol , vol.44 , Issue.2 , pp. 275-283
    • Hunt, C.M.1    Westerkam, W.R.2    Stave, G.M.3
  • 61
    • 0029128788 scopus 로고
    • Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
    • George J, Byth K, Farrell GC (1995) Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol 50(5):727-730
    • (1995) Biochem Pharmacol , vol.50 , Issue.5 , pp. 727-730
    • George, J.1    Byth, K.2    Farrell, G.C.3
  • 63
    • 0027424888 scopus 로고
    • Determination of the serum protein binding of oxycodone and morphine using ultrafiltration
    • Leow KP, Wright AW, Cramond T, Smith MT (1993) Determination of the serum protein binding of oxycodone and morphine using ultrafiltration. Ther Drug Monit 15 (5):440-447 (Pubitemid 23297249)
    • (1993) Therapeutic Drug Monitoring , vol.15 , Issue.5 , pp. 440-447
    • Leow, K.P.1    Wright, A.W.E.2    Cramond, T.3    Smith, M.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.