Antigen-specific CD8+ T cells fail to respond to Shigella flexneri

Infection and Immunity

Volumn 79, Issue 5, 2011, Pages 2021-2030

  Jehl, Stephanie P ^a   Doling, Amy M ^a   Giddings, Kara S ^a   Phalipon, Armelle ^b   Sansonetti, Philippe J ^b   Goldberg, Marcia B ^a,c   Starnbach, Michael N ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUT PASTEUR   (France)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; EPITOPE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL VIRULENCE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOPLASM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHIGELLA FLEXNERI; SHIGELLOSIS;

ANIMALS; ANTIGENS, BACTERIAL; CD8-POSITIVE T-LYMPHOCYTES; DYSENTERY, BACILLARY; EPITOPES, T-LYMPHOCYTE; IMMUNOBLOTTING; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; SHIGELLA FLEXNERI;

EID: 79955639603     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00939-10     Document Type: Article

References (53)

1. Ahmed, R., A. Salmi, L. D. Butler, J. M. Chiller, and M. B. Oldstone. 1984. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160:521-540.
2. Ballard, J. D., R. J. Collier, and M. N. Starnbach. 1998. Anthrax toxin as a molecular tool for stimulation of cytotoxic T lymphocytes: disulfide-linked epitopes, multiple injections, and role of CD4(+) cells. Infect. Immun. 66:4696-4699.
3. Ballard, J. D., R. J. Collier, and M. N. Starnbach. 1996. Anthrax toxin mediated delivery of a cytotoxic T-cell epitope in vivo. Proc. Natl. Acad. Sci. U. S. A. 93:12531-12534.
4. Ballard, J. D., A. M. Doling, K. Beauregard, R. J. Collier, and M. N. Starnbach. 1998. Anthrax toxin-mediated delivery in vivo and in vitro of a cytotoxic T-lymphocyte epitope from ovalbumin. Infect. Immun. 66:615-619.
5. Barzu, S., Z. Benjelloun-Touimi, A. Phalipon, P. Sansonetti, and C. Parsot. 1997. Functional analysis of the Shigella flexneri IpaC invasin by insertional mutagenesis. Infect. Immun. 65:1599-1605.
6. Bernardini, M. L., J. Mounier, H. d'Hauteville, M. Coquis-Rondon, and P. J. Sansonetti. 1989. Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. Proc. Natl. Acad. Sci. U. S. A. 86:3867-3871.
7. Carneiro, L. A., et al. 2009. Shigella induces mitochondrial dysfunction and cell death in nonmyeloid cells. Cell Host Microbe 5:123-136.
8. Chen, Y., M. R. Smith, K. Thirumalai, and A. Zychlinsky. 1996. A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J. 15:3853-3860.
9. Clerc, P. L., A. Ryter, J. Mounier, and P. J. Sansonetti. 1987. Plasmid-mediated early killing of eucaryotic cells by Shigella flexneri as studied by infection of J774 macrophages. Infect. Immun. 55:521-527.
10. Cormack, B. P., R. H. Valdivia, and S. Falkow. 1996. FACS-optimized mutants of the green fluorescent protein (GFP). Gene 173:33-38.
11. Doling, A. M., et al. 1999. Cytotoxic T-lymphocyte epitopes fused to anthrax toxin induce protective antiviral immunity. Infect. Immun. 67:3290-3296.
12. Dutko, F. J., and M. B. Oldstone. 1983. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains. J. Gen. Virol. 64:1689-1698.
13. Faas, S. J., J. L. Rothstein, B. L. Kreider, G. Rovera, and B. B. Knowles. 1993. Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells. Eur. J. Immunol. 23:1201-1214.
14. Finlay, B. B., and S. Falkow. 1988. Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication. Biochimie 70:1089-1099.
15. Fling, S. P., et al. 2001. CD8+ T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis. Proc. Natl. Acad. Sci. U. S. A. 98:1160-1165.
16. Hilbi, H., et al. 1998. Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. J. Biol. Chem. 273:32895-32900.
17. Huber, M., et al. 2009. A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur. J. Immunol. 39:1716-1725.
18. Islam, D., and B. Christensson. 2000. Disease-dependent changes in T-cell populations in patients with shigellosis. APMIS 108:251-260.
19. Islam, D., B. Veress, P. K. Bardhan, A. A. Lindberg, and B. Christensson. 1997. Quantitative assessment of IgG and IgA subclass producing cells in rectal mucosa during shigellosis. J. Clin. Pathol. 50:513-520.
20. Islam, D., B. Wretlind, A. A. Lindberg, and B. Christensson. 1996. Changes in the peripheral blood T-cell receptor V beta repertoire in vivo and in vitro during shigellosis. Infect. Immun. 64:1391-1399.
21. Karttunen, J., S. Sanderson, and N. Shastri. 1992. Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens. Proc. Natl. Acad. Sci. U. S. A. 89:6020-6024.
22. Kim, D. W., et al. 2005. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proc. Natl. Acad. Sci. U. S. A. 102:14046-14051.
23. Labrec, E. H., H. Schneider, T. J. Magnani, and S. B. Formal. 1964. Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J. Bacteriol. 88:1503-1518.
24. Le-Barillec, K., et al. 2005. Roles for T and NK cells in the innate immune response to Shigella flexneri. J. Immunol. 175:1735-1740.
25. Li, P., et al. 1995. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80:401-411.
26. Lu, Y., et al. 2000. Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity. Proc. Natl. Acad. Sci. U. S. A. 97:8027-8032.
27. Lyons, A. B., J. Hasbold, and P. D. Hodgkin. 2001. Flow cytometric analysis of cell division history using dilution of carboxyfluorescein diacetate succin-imidyl ester, a stably integrated fluorescent probe. Methods Cell Biol. 63: 375-398.
28. Maurelli, A. T., B. Blackmon, and R. Curtiss III. 1984. Loss of pigmentation in Shigella flexneri 2a is correlated with loss of virulence and virulence-associated plasmid. Infect. Immun. 43:397-401.
29. Menard, R., M. C. Prevost, P. Gounon, P. Sansonetti, and C. Dehio. 1996. The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 93:1254-1258.
30. Menard, R., P. J. Sansonetti, and C. Parsot. 1993. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J. Bacteriol. 175:5899-5906.
31. Phalipon, A., et al. 1995. Monoclonal immunoglobulin A antibody directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis. J. Exp. Med. 182:769-778.
32. Raqib, R., A. Gustafsson, J. Andersson, and M. Bakhiet. 1997. A systemic downregulation of gamma interferon production is associated with acute shigellosis. Infect. Immun. 65:5338-5341.
33. Raqib, R., et al. 2002. Delayed and reduced adaptive humoral immune responses in children with shigellosis compared with in adults. Scand. J. Immunol. 55:414-423.
34. Russmann, H., et al. 1998. Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science 281:565-568.
35. Russmann, H., et al. 2000. Yersinia enterocolitica-mediated translocation of defined fusion proteins to the cytosol of mammalian cells results in peptide-specific MHC class I-restricted antigen presentation. Eur. J. Immunol. 30: 1375-1384.
36. Sanderson, S., and N. Shastri. 1994. LacZ inducible, antigen/MHC-specific T cell hybrids. Int. Immunol. 6:369-376.
37. Sansonetti, P., and A. Phalipon. 1996. Shigellosis: from molecular patho-genesis of infection to protective immunity and vaccine development. Res. Immunol. 147:595-602.
38. Sansonetti, P. J. 2001. Rupture, invasion and inflammatory destruction of the intestinal barrier by Shigella, making sense of prokaryote-eukaryote cross-talks. FEMS Microbiol. Rev. 25:3-14.
39. Sansonetti, P. J., D. J. Kopecko, and S. B. Formal. 1982. Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect. Immun. 35:852-860.
40. Schaible, U. E., et al. 2003. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat. Med. 9:1039-1046.
41. Sellge, G., et al. 2010. Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity. J. Immunol. 184:2076-2085.
42. Suzuki, T., et al. 2005. A novel caspase-1/Toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages. J. Biol. Chem. 280:14042-14050.
43. van der Velden, A. W., M. K. Copass, and M. N. Starnbach. 2005. Salmonella inhibit T cell proliferation by a direct, contact-dependent immunosuppres-sive effect. Proc. Natl. Acad. Sci. U. S. A. 102:17769-17774.
44. Voino-Yasenetsky, M. V., and M. K. Voino-Yasenetskaya. 1962. Experimental pneumonia caused by bacteria of the Shigella group. Acta Morphol. Acad. Sci. Hung. 11:439-454.
45. Way, S. S., A. C. Borczuk, and M. B. Goldberg. 1999. Thymic independence of adaptive immunity to the intracellular pathogen Shigella flexneri serotype 2a. Infect. Immun. 67:3970-3979.
46. Welsh, R. M., Jr., P. W. Lampert, P. A. Burner, and M. B. Oldstone. 1976. Antibody-complement interactions with purified lymphocytic choriomeningitis virus. Virology 73:59-71.
47. Williams, D. B., S. J. Swiedler, and G. W. Hart. 1985. Intracellular transport of membrane glycoproteins: two closely related histocompatibility antigens differ in their rates of transit to the cell surface. J. Cell Biol. 101:725-734.
48. Yrlid, U., and M. J. Wick. 2000. Salmonella-induced apoptosis of infected macrophages results in presentation of a bacteria-encoded antigen after uptake by bystander dendritic cells. J. Exp. Med. 191:613-624.
49. Zarozinski, C. C., R. J. Collier, and M. N. Starnbach. 2000. Use of anthrax toxin fusions to stimulate immune responses. Methods Enzymol. 326:542-551.
50. Zychlinsky, A., et al. 1994. IpaB mediates macrophage apoptosis induced by Shigella flexneri. Mol. Microbiol. 11:619-627.
51. Zychlinsky, A., B. Kenny, M. C. Prevost, I. B. Holland, and P. J. Sansonetti. 1993. The ipaB gene of Shigella flexneri and macrophage-programmed cell death. Infect. Agents Dis. 2:212-214.
52. Zychlinsky, A., M. C. Prevost, and P. J. Sansonetti. 1992. Shigella flexneri induces apoptosis in infected macrophages. Nature 358:167-169.
53. Zychlinsky, A., et al. 1996. In vivo apoptosis in Shigella flexneri infections. Infect. Immun. 64:5357-5365.