Thymic independence of adaptive immunity to the intracellular pathogen Shigella flexneri serotype 2a

Infection and Immunity

Volumn 67, Issue 8, 1999, Pages 3970-3979

  Way, Sing Sing ^a   Borczuk, Alain C ^a,c   Goldberg, Marcia B ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NORTH SHORE UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CELL COMPARTMENTALIZATION; CELL PROTECTION; CELLULAR IMMUNITY; COMPLEMENT FIXATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEROTYPE; SHIGELLA FLEXNERI; THYMUS; VACCINATION;

EID: 0345120579     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.8.3970-3979.1999     Document Type: Article

References (69)

1. Andersson, J., and H. Blomgren. 1971. Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide. Cell. Immunol. 2:411-424.
2. Andersson, J., O. Sjoberg, and G. Moller. 1972. Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharide. Eur. J. Immunol. 2:349-353.
3. Bernardini, M. L., J. Mounier, H. d'Hauteville, M. Coquis-Rondon, and P. J. Sansonetti. 1989. Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. Proc. Natl. Acad. Sci. USA 84:3867-3871.
4. Bishop, D. K., and D. J. Hinrichs. 1987. Adoptive transfer of immunity to Listeria monocytogenes. The influence of in vitro stimulation on lymphocyte subset requirements. J. Immunol. 139:2005-2009.
5. Cohen, D., S. Ashkenazi, M. S. Green, M. Gdalevich, G. Robin, R. Slepon, M. Yavzori, N. Orr, C. Block, I. Ashkenazi, J. Shemer, D. N. Taylor, T. L. Hale, J. C. Sadoff, D. Pavliakova, R. Schneerson, and J. B. Robbins. 1997. Double-blind vaccine-controlled randomised efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults. Lancet 349:155-159.
6. Cohen, D., C. Block, M. S. Green, G. Lowell, and I. Ofek. 1989. Immunoglobulin M, A, and G antibody response to lipopolysaccharide O antigen in symptomatic and asymptomatic Shigella infections. J. Clin. Microbiol. 27: 162-167.
7. Dalton, D., S. Pitts-Meek, S. Keshav, I. Figrai, A. Bradley, and T. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 264:1415-1421.
8. Farrell, J. P., I. Muller, and J. A. Louis. 1989. A role for Lyt-2 T cells in resistance to cutaneous leishmaniasis in immunized mice. J. Immunol. 143: 2052-2056.
9. Ferreccio, C., V. Prado, A. Oleda, M. Cayyazo, P. Abrego, L. Guers, and M. L. Levine. 1991. Epidemiologic patterns of acute diarrhea and endemic Shigella infections in children in a poor periurban setting in Santiago, Chile. Am. J. Epidemiol. 134:614-627.
10. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, M. P. Beckmann, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303-333.
11. Formal, S. B., G. J. Dammin, E. H. LaBrec, and H. Schneider. 1958. Experimental Shigella infections: characteristics of a fatal infection produced in guinea pigs. J. Bacteriol. 75:604-610.
12. Formal, S. B., E. V. Oaks, R. E. Olsen, M. Wingfield-Eggleston, P. J. Snoy, and J. P. Cogan. 1991. Effect of prior infection with virulent Shigella flexneri 2a on the resistance of monkeys to subsequent infection with Shigella sonnei. J. Infect. Dis. 164:533-537.
13. Harty, J. T., and M. J. Bevan. 1992. CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo. J. Exp. Med 175:1531-1538.
14. Harty, J. T., and M. J. Bevan. 1995. Specific immunity to Listeria monocytogenes in the absence of IFNγ. Immunity 3:109-117.
15. Harty, J. T., and E. G. Pamer. 1995. CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection. J. Immunol. 154:4642-4650.
16. Harty, J. T., R. D. Schreiber, and M. J. Bevan. 1992. CD8+ T cells can protect against an intracellular bacterium in an interferon-γ-independent fashion. Proc. Natl. Acad. Sci. USA 89:11612-11616.
17. Islam, D., B. Veress, P. K. Bardhan, A. A. Lindberg, and B. Christensson. 1997. Quantitative assessment of IgG and IgA subclass producing cells in rectal mucosa during shigellosis. J. Clin. Pathol. 50:513-520.
18. Islam, D., B. Wretlind, M. Ryd, A. A. Lindberg, and B. Christensson. 1995. Immunoglobulin subclass distribution and dynamics of Shigella-specific antibody responses in serum and stool samples. Infect. Immun. 63:2054-2061.
19. Jacobs, D. M., and D. C. Morrison. 1975. Stimulation of a T-independent primary anti-hapten response in vitro by TNP-lipopolysaccharide (TNP-LPS). J. Immunol. 114:360-370.
20. Kagi, D., B. Ledermann, K. Burki, H. Hengartner, and R. M. Zinkernagel. 1994. CD8+ T cell-mediated protection against an intracellular bacterium, by perforin-dependent cytotoxicity. Eur. J. Immunol. 24:3068-3072.
21. Kaufmann, S. H. E., E. Hug, L. Vath, and G. D. Libero. 1987. Specific lysis of Listeria monocytogenes-infected macrophages by class II-restricted L3T4+ T cells. Eur. J. Immunol. 17:237-246.
22. Kaufmann, S. H. E., H.-R. Rodewald, E. Hug, and G. D. Libero. 1988. Cloned Listeria monocytogenes specific non-MHC-restricted Lyt-2+ T cells with cytolytic and protective activity. J. Immunol. 140:3173-3179.
23. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350:423-426.
24. Lerman, Y., K. Yavzori, R. Ambar, I. Sechter, M. Weiner, and D. Cohen. 1994. Epidemic spread of Shigella sonnei shigellosis and evidence for development of immunity among children attending day-care centers in a communal settlement (kibbutz). J. Clin. Microbiol. 32:1092-1094.
25. Libero, G. D., and S. H. E. Kaufmann. 1986. Antigen-specific Lyt-2+ cytolytic lymphocytes from mice infected with the intracellular bacterium Listeria monocytogenes. J. Immunol. 137:2688-2694.
26. Lindberg, A. A., A. Karnell, and A. Weintraub. 1991. The lipopolysaccharide of Shigella bacteria as a virulence factor. Rev. Infect. Dis. 13:S279-S284.
27. Magee, D. M., and E. J. Wing. 1988. Cloned L3T4+ T lymphocytes protect mice against Listeria monocytogenes by secreting INF-γ. J. Immunol. 141: 3203-3207.
28. Mallett, C. P., L. VanDeVerg, H. H. Collins, and T. L. Hale. 1993. Evaluation of Shigella vaccine safety and efficacy in an intranasal challenged mouse model. Vaccine 11:190-196.
29. Mandic-Mulec, I., J. Weiss, and A. Zychlinsky. 1997. Shigella flexneri is trapped in polymorphonuclear leukocyte vacuoles and efficiently killed. Infect. Immun. 65:110-115.
30. Mathan, M. M., and V. I. Mathan. 1991. Morphology of rectal mucosa of patients with shigellosis. Rev. Infect. Dis. 13:S314-S318.
31. Mel, D. M., B. L. Arsic, B. D. Nikolic, and M. L. Radovanic. 1968. Studies on vaccination against bacillary dysentery. 4. Oral immunization with live monotypic and combined vaccines. Bull. W. H. O. 39:375-380.
32. Mel, D. M., E. J. Gangarosa, M. L. Radovanovic, B. L. Arsic, and S. Litvinjenko. 1971. Studies on vaccination against bacillary dysentery. 6. Protection of children by oral immunization with streptomycin-dependent Shigella strains. Bull. W. H. O. 45:457-464.
33. Mel, D. M., A. L. Terzin, and L. Vuksic. 1965. Studies on vaccination against bacillary dysentery. 3. Effective oral immunization against Shigella flexneri 2a in a field trial. Bull. W. H. O. 32:647-655.
34. Mielke, M. E. A., S. Ehlers, and H. Hahn. 1988. T-cell subsets in delayed-type hypersensitivity, protection, and granuloma formation in primary and secondary Listeria infection in mice: superior role of Lyt-2+ cells in acquired immunity. Infect. Immun. 56:1920-1925.
35. + T cells independently of the influx of monocytes into granulomatous lesions. J. Exp. Med. 170:589-594.
36. Miller, M. A., M. J. Skeen, and H. K. Ziegler. 1995. Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes. J. Immunol. 155: 4817-4828.
37. Miller, M. A., M. J. Skeen, and H. K. Ziegler. 1997. A synthetic peptide administered with IL-12 elicits immunity to Listeria monocytogenes. J. Immunol. 159:3675-3679.
38. Moller, G., and G. Michael. 1971. Frequency of antigen-sensitive cells to thymus-independent antigens. Cell. Immunol. 2:309-316.
39. Mombaerts, P., A. Clarke, M. Rudnicki, J. Iacomini, S. Itohara, J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, N. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes α and α block thymocyte development at different stages. Nature 360:225-231.
40. Mosier, D. E., I. Scher, and W. E. Paul. 1976. In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TPN-lipopolysaccharide. J. Immunol. 117:1363-1369.
41. North, R. J. 1973. Cellular mediators of anti-Listeria immunity as an enlarged population of short-lived, replicating T cells. J. Exp. Med. 138:342-355.
42. Orme, I. M. 1988. Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection. J. Immunol. 140:3589-3593.
43. Orme, I. M. 1987. The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis. J. Immunol. 138:293-298.
44. Orme, I. M., and F. M. Collins. 1984. Adoptive protection of the Mycobacterium tuberculosis-infected lung. Cell. Immunol. 84:113-120.
45. Orme, I. M., E. S. Miller, A. D. Roberts, S. K. Furney, J. P. Griffin, K. M. Dobos, D. Chi, B. Rivoire, and P. J. Brennan. 1992. T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. J. Immunol. 148:189-196.
46. Orr, N., G. Robin, G. Lowell, and D. Cohen. 1992. Presence of specific immunoglobulin A-secreting cells in peripheral blood after natural infection with Shigella sonnei. J. Clin. Microbiol. 30:2165-2168.
47. Peavy, D. L., W. H. Adler, and R. T. Smith. 1970. The mitogenic effects of endotoxin and staphylococcal enterotoxin B on mouse spleen cells and human peripheral lymphocytes. J. Immunol. 105:1453-1458.
48. Phalipon, A., M. Kaufmann, P. Michetti, J.-M. Cavaillon, M. Huerre, P. Sansonetti, and J.-P. Kraehenbuhl. 1995. Monoclonal immunoglobulin A antibody directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis. J. Exp. Med. 182:769-778.
49. Prevost, M. C., M. Lesourd, M. Arpin, F. Vernel, J. Mounier, R. Hellio, and P. J. Sansonetti. 1992. Unipolar reorganization of F-actin layer at bacterial division and bundling of actin filaments by plastin correlate with movement of Shigella flexneri within HeLa cells. Infect. Immun. 60:4088-4099.
50. Raqib, R., A. Lindberg, L. Bjork, P. Bardhan, B. Wretlind, U. Andersson, and J. Andersson. 1995. Down-regulation of gamma interferon, tumor necrosis factor type I, interleukin 1 (IL-1) type I, IL-3, IL-4, and transforming growth factor β type I receptors at the local site during acute phase of Shigella infection. Infect. Immun. 63:3079-3087.
51. Reed, W. P. 1975. Serum factors capable of opsonizing Shigella for phagocytosis by polymorphonuclear leukocytes. Immunol. 28:1051-1059.
52. Reed, W. P., and E. L. Albright. 1974. Secretory IgA and direct killing of Shigella by serum components. Adv. Exp. Biol. Med. 45:343-347.
53. Reed, W. P., and E. L. Albright. 1974. Serum factors responsible for killing of Shigella. Immunology 26:205-215.
54. Robin, G., D. Cohen, N. Orr, I. Markus, R. Slepon, S. Ashkenazi, and Y. Keisari. 1997. Characterization and quantitative analysis of serum IgG class and subclass response to Shigella sonnei and Shigella flexneri 2a lipopolysaccharide following natural Shigella infection. J. Infect. Dis. 175:1128-1133.
55. Sansonetti, P. J., J. Arondel, A. Fontaine, H. d'Hauteville, and M. L. Bernardini. 1991. ompB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis. Vaccine 9:416-422.
56. Sansonetti, P. J., D. J. Kopecko, and S. B. Formal. 1982. Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect. Immun. 35:852-860.
57. Schrader, J. W. 1974. The mechanism of bone marrow-derived B lymphocyte activation. II. A "second signal" for antigen-specific activation provided by flagellin and polysaccharide. Eur. J. Immunol. 4:20-24.
58. Scott, P., P. Casper, and A. Sher. 1990. Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes. J. Immunol. 144:1075-1079.
59. Scott, P., P. Natovitz, R. L. Coffman, E. Pearce, and A. Sher. 1988. Immunoregulation of cutaneous leishmaniasis. J. Exp. Med. 168:1675-1684.
60. Seder, R. A., W. E. Paul, M. M. Davis, and B. F. S. Groth. 1992. The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091-1098.
61. Stein, K. E. 1992. Thymus-independent and thymus-dependent responses to polysaccharide antigens. J. Infect. Dis. 165:S49-S52.
62. Swihart, K., U. Fruth, N. Messmer, K. Hug, R. Behin, S. Huang, G. D. Giudice, M. Aguet, and J. A. Louis. 1995. Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type response. J. Exp. Med. 181:961-971.
63. Taylor, D. N., L. Bodhidatta, J. E. Brown, P. Echeverria, C. Kunanusont, P. Naigowit, S. Hanchalay, A. Chatkaeomorakot, and A. A. Lindberg. 1989. Introduction and spread of multi-resistant Shigella dysenteriae 1 in Thailand. Am. J. Trop. Med. Hyg. 40:77-85.
64. VanDeVerg, L. L., C. P. Mallett, H. H. Collins, T. Larsen, C. Hammack, and T. L. Hale. 1995. Antibody and cytokine responses in a mouse pulmonary model of Shigella flexneri serotype 2a infection. Infect. Immun. 63:1947-1954.
65. Wang, Z.-E., S. L. Reiner, S. Zheng, D. K. Dalton, and R. M. Locksley. 1994. CD4+ effector cells default to the Th2 pathway in interferon γ-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367-1371.
66. Way, S. S., A. C. Borczuk, R. Dominitz, and M. B. Goldberg. 1998. An essential role for gamma interferon in innate resistance to Shigella flexneri infection. Infect. Immun. 66:1342-1348.
67. Way, S. S., A. C. Borczuk, and M. B. Goldberg. 1999. Adaptive immune response to Shigella flexneri 2a cydC in immunocompetent mice and mice lacking immunoglobulin A. Infect. Immun. 67:2001-2004.
68. Way, S. S., S. Salluslio, R. S. Magliozzo, and M. B. Goldberg. 1999. The impact of either elevated or decreased levels of cytochrome bd expression on Shigella flexneri virulence. J. Bacleriol. 181:1229-1237.
69. Zychlinsky, A., K. Thirumalai, J. Arondel, J. Cantey, A. Aliprantis, and P. Sansonetti. 1996. In vivo apoptosis in Shigella flexneri infections. Infect. Immun. 64:5357-5365.