Progress in biological threat agent vaccine development: A repeat-dose toxicity study of a recombinant ricin toxin A-chain (rRTA) 1-33/44-198 vaccine (RVEc) in male and female New Zealand white rabbits

International Journal of Toxicology

Volumn 30, Issue 2, 2011, Pages 143-152

  McLain, Daniel E ^a   Horn, Thomas L ^b   Detrisac, Carol J ^c   Lindsey, Changhong Y ^d   Smith, Leonard A ^d  

^a Walker Downey and Associates Inc   (United States)

^b IIT RESEARCH INSTITUTE   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

biological threat agent; NOAEL; recombinant vaccine; ricin toxin

Indexed keywords

RICIN A;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; AUTOPSY; CONTROLLED STUDY; DRUG TOXICITY; FEMALE; IMMUNE RESPONSE; MALE; NEW ZEALAND; NONHUMAN; RABBIT; THREAT; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, NEUTRALIZING; BIOLOGICAL PRODUCTS; BIOLOGICAL WARFARE AGENTS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; FEMALE; IMMUNOGLOBULIN G; MALE; MODELS, ANIMAL; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RABBITS; RICIN; VACCINES, SYNTHETIC;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 79955635252     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581810396730     Document Type: Article

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