Experimental and theoretical analysis of poly(β-hydroxybutyrate) formation and consumption in Ralstonia eutropha

Biochemical Engineering Journal

Volumn 55, Issue 1, 2011, Pages 49-58

  Franz, André ^a,d   Song, Hyun Seob ^b   Ramkrishna, Doraiswami ^b   Kienle, Achim ^a,c,d  

^a MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

^b PURDUE UNIVERSITY   (United States)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d Magdeburg Centre for Systems Biology MaCS   (Germany)

Author keywords

Bifurcation analysis; Biopolymers; Cybernetic modeling; Elementary mode; Metabolic regulation; Ralstonia eutropha

Indexed keywords

BIFURCATION ANALYSIS; CYBERNETIC MODELING; ELEMENTARY MODE; METABOLIC REGULATIONS; RALSTONIA EUTROPHA;

BACTERIA; BIFURCATION (MATHEMATICS); BIOMOLECULES; BIOPOLYMERS; MATHEMATICAL MODELS; METABOLITES;

METABOLISM;

POLY(3 HYDROXYBUTYRIC ACID);

ARTICLE; BIOREACTOR; CUPRIAVIDUS NECATOR; CYBERNETICS; EXPERIMENTAL STUDY; MATHEMATICAL MODEL; NONHUMAN; NONLINEAR SYSTEM; PRIORITY JOURNAL; STEADY STATE; SYNTHESIS; THEORETICAL STUDY; VALIDATION PROCESS;

CUPRIAVIDUS NECATOR;

EID: 79955632301     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2011.03.006     Document Type: Article

References (34)

1. Kim J.I., Varner J.D., Ramkrishna D. A hybrid model of anaerobic E. coli GJT001: combination of elementary flux modes and cybernetic variables. Biotechnol. Prog. 2008, 24:993-1006.
2. Reinecke F., Steinbüchel A. Ralstonia eutropha strain H16 as model organism for PHA metabolism and for biotechnological production of technically interesting biopolymers. J. Mol. Microbiol. Biotechnol. 2009, 16:91-108.
3. Anderson A.J., Dawes E.A. Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol. Rev. 1990, 54:450-472.
4. Asenjo J.A., Suk J.S. Kinetics and models for the bioconversion of methane into an intracellular polymer poly-beta-hydroxybutyrate. Biotechnol. Bioeng. Symp. 1986, 15:225-234.
5. Mulchandani A., Luong J.H.T., Groom C. Substrate-inhibition kinetics for microbial-growth and synthesis of poly-beta-hydroxybutyric acid by Alcaligenes eutrophus ATCC-17697. Appl. Microbiol. Biotechnol. 1989, 30:11-17.
6. Kompala D.S., Ramkrishna D., Tsao G.T. Cybernetic modeling of microbial growth on multiple substrates. Biotechnol. Bioeng. 1984, 26:1272-1281.
7. Ramkrishna D. A cybernetic perspective of microbial growth. ACS Symp. Ser. 1983, 207:161-178.
8. Ramkrishna D., Kompala D.S., Tsao G.T. Are microbes optimal strategists. Biotechnol. Prog. 1987, 3:121-126.
9. Yoo S., Kim W.S. Cybernetic model for synthesis of poly-beta-hydroxybutyric acid in Alcaligenes eutrophus. Biotechnol. Bioeng. 1994, 43:1043-1051.
10. Gadkar K.G., Doyle F.J., Crowley T.J., Varner J.D. Cybernetic model predictive control of a continuous bioreactor with cell recycle. Biotechnol. Prog. 2003, 19:1487-1497.
11. M.A. Pinto, C.D. Immanuel, Sensitivity of bifurcation traits to model parameters in poly-beta-hydroxy butyrate production, in: ADCHEM.
12. Stelling J., Klamt S., Bettenbrock K., Schuster S., Gilles E.D. Metabolic network structure determines key aspects of functionality and regulation. Nature 2002, 420:190-193.
13. Young J.D., Henne K.L., Morgan J.A., Konopka A.E., Ramkrishna D. Integrating cybernetic modeling with pathway analysis provides a dynamic, systems-level description of metabolic control. Biotechnol. Bioeng. 2008, 100:542-559.
14. Weber J., Kayser A., Rinas U. Metabolic flux analysis of Escherichia coli in glucose-limited continuous culture. ii. Dynamic response to famine and feast, activation of the methylglyoxal pathway and oscillatory behaviour. Microbiology-SGM 2005, 151:707-716.
15. Jones K.D., Kompala D.S. Cybernetic model of the growth dynamics of Saccharomyces cerevisiae in batch and continuous cultures. J. Biotechnol. 1999, 71:105-131.
16. I. Disli, A. Kremling, A. Kienle, A model based analysis of multiple steady states in continuous cell cultures, in: Proceedings MATHMOD 09 Vienna - Full Papers CD Volume.
17. Kumar M.V., Zeyer K.P., Kienle A., Pushpavanam S. Conceptual analysis of the effect of kinetics on the stability and multiplicity of a coupled bioreactor-separator system using a cybernetic modeling approach. Ind. Eng. Chem. Res. 2009, 48:10962-10975.
18. Namjoshi A.A., Hu W.S., Ramkrishna D. Unveiling steady-state multiplicity in hybridoma cultures: The cybernetic approach. Biotechnol. Bioeng. 2003, 81:80-91.
19. Law J.H., Slepecky R.A. Assay of poly-beta-hydroxybutyric acid. J. Bacteriol. 1961, 82:33.
20. Song H.S., Ramkrishna D. Reduction of a set of elementary modes using yield analysis. Biotechnol. Bioeng. 2009, 102:554-568.
21. Song H.S., Morgan J.A., Ramkrishna D. Systematic development of hybrid cybernetic models: application to recombinant yeast co-consuming glucose and xylose. Biotechnol. Bioeng. 2009, 103:984-1002.
22. von Kamp A., Schuster S. Metatool 5.0: fast and flexible elementary modes analysis. Bioinformatics 2006, 22:1930-1931.
23. Klamt S., Saez-Rodriguez J., Gilles E.D. Structural and functional analysis of cellular networks with CellNetAnalyzer. BMC Syst. Biol. 2007, 1.
24. Young J.D., Ramkrishna D. On the matching and proportional laws of cybernetic models. Biotechnol. Prog. 2007, 23:83-99.
25. Turner B.G., Ramkrishna D. Revised enzyme-synthesis rate expression in cybernetic models of bacterial-growth. Biotechnol. Bioeng. 1988, 31:41-43.
26. Katoh T., Yuguchi D., Yoshii H., Shi H.D., Shimizu K. Dynamics and modeling on fermentative production of poly (beta-hydroxybutyric acid) from sugars via lactate by a mixed culture of Lactobacillus delbrueckii and Alcaligenes eutrophus. J. Biotechnol. 1999, 67:113-134.
27. Yu S.T., Lin C.C., Too J.R. Phbv production by Ralstonia eutropha in a continuous stirred tank reactor. Process. Biochem. 2005, 40:2729-2734.
28. Wu S.T., Lin Y.C., Too J.R. Continuous production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate): Effects of c/n ratio and dilution rate on hb/hv ratio. Korean J. Chem. Eng. 2009, 26:411-416.
29. Khanna S., Srivastava A.K. Optimization of nutrient feed concentration and addition time for production of poly(beta-hydroxybutyrate). Enzyme Microb. Technol. 2006, 39:1145-1151.
30. Mangold M., Kienle A., Gilles E.D., Mohl K.D. Nonlinear computation in DIVA-methods and applications. Chem. Eng. Sci. 2000, 55:441-454.
31. König C., Schlegel H.G. Prolonged organotrophic growth of hydrogenomonas H16 in chemostat. Arch. Mikrobiol. 1968, 62:41-55.
32. Namjoshi A.A., Ramkrishna D. Multiplicity and stability of steady states in continuous bioreactors: dissection of cybernetic models. Chem. Eng. Sci. 2001, 56:5593-5607.
33. Shahhosseini S. Simulation and optimisation of PHB production in fed-batch culture of Ralstonia eutropha. Process. Biochem. 2004, 39:963-969.
34. Lopez J.A., Bucala V., Villar M.A. Application of dynamic optimization techniques for poly(beta-hydroxybutyrate) production in a fed-batch bioreactor. Ind. Eng. Chem. Res. 2010, 49:1762-1769.