Increased matrix metalloproteinases-1,-9 in the uterosacral ligaments and vaginal tissue from women with pelvic organ prolapse

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 156, Issue 1, 2011, Pages 113-117

  Dviri, Michal ^a   Leron, Elad ^a   Dreiher, Jacob ^a   Mazor, Moshe ^a   Shaco Levy, Ruthy ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Matrix metalloproteinase 1; Matrix metalloproteinase 9; Pelvic organ prolapse; Uterosacral ligaments; Vaginal mucosa

Indexed keywords

EOSIN; GELATINASE B; HEMATOXYLIN; INTERSTITIAL COLLAGENASE;

ADULT; AGED; ARTICLE; BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIGAMENT; LYMPHOCYTE; PELVIC ORGAN PROLAPSE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTEROSACRAL LIGAMENT; UTERUS MYOMA; VAGINA MUCOSA; VAGINAL BIOPSY;

EID: 79955626737     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2010.12.043     Document Type: Article

References (24)

1. Balmforth J, Cardozo L. Management of pelvic organ prolapse. London, UK: Department of Urogynecology, King's College Hospital; 2006[Website TTMED Urology].
2. Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. Lancet 2007;369:1027-38. (Pubitemid 46436126)
3. Nikolova G, Lee H, Berkovitz S, et al. Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. Hum Genet 2007;120:847-56. (Pubitemid 46128840)
4. Twiss C, Triaca V, Rodríguez LV. Familial transmission of urogenital prolapse and incontinence. Curr Opin Obstet Gynecol 2007;19:464-8. (Pubitemid 47462240)
5. Subak LL, Waetjen LE, van den Eeden S, Thom DH, Vittinghoff E, Brown JS. Cost of pelvic organ prolapse surgery in the United States. Obstet Gynecol 2001;98:646-51. (Pubitemid 32907461)
6. Wu JM, Hundley AF, Fulton RG, Myers ER. Forecasting the prevalence of pelvic floor disorders in U.S. Women: 2010 to 2050. Obstet Gynecol 2009;114:1278-83.
7. Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol 1997;89:501-6. (Pubitemid 27133519)
8. Denman MA, Gregory WT, Boyles SH, Smith V, Edwards SR, Clark AL. Reoperation 10 years after surgically managed pelvic organ prolapse and urinary incontinence. Am J Obstet Gynecol 2008;198:555.e1-5.
9. James R, Scott RS, Gibbs BY, Karlan AF, Haney DN. Pelvic organ prolapse. In: Danforth's obstetrics and gynecology 9th ed., Lippincott; 2003. p. 436-37 [chapter 45].
10. Ewies AA, Al-Azzawi F, Thompson J. Changes in extracellular matrix proteins in the cardinal ligaments of post-menopausal women with or without prolapse: a computerized immunohistomorphometric analysis. Hum Reprod 2003;18:2189-95. (Pubitemid 37270559)
11. Phillips CH, Anthony F, Benyon C, Monga AK. Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapse. Br J Obstet Gynaecol 2006;113:39-46.
12. Jackson SR, Avery NC, Tarlton JF, Eckford SD, Abrams P, Bailey AJ. Changes in metabolism of collagen in genitourinary prolapse. Lancet 1996;347:1658-61.
13. Moalli PA, Shand SH, Zyczynski HM, Gordy SC, Meyn LA. Remodeling of vaginal connective tissue in patients with prolapse. Obstet Gynecol 2005;106:953-63. (Pubitemid 41532900)
14. Chen BH, Wen Y, Li H, Polan ML. Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse. Int Urogynecol J 2002;13:80-7. (Pubitemid 34591422)
15. Strinic T, Vulic M, Tomic S, Capkun V, Stipic I, Alujevic I. Matrix metalloproteinases- 1, -2 expression in uterosacral ligaments from women with pelvic organ prolapse. Maturitas 2009;64:132-5.
16. Gabriel B, Watermann D, Hancke K, et al. Increased expression of matrix metalloproteinase 2 in uterosacral ligaments is associated with pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct 2006;17:478-82. (Pubitemid 44138253)
17. Kerkhof MH, Hendriks L, Brölmann HA. Changes in connective tissue in patients with pelvic organ prolapse - a review of the current literature. Int Urogynecol J Pelvic Floor Dysfunct 2009;20:461-74.
18. Soderberg MW, Falconer C, Bystrom B, Malmstrom A, Ekman G. Young women with genital prolapse have a low collagen concentration. Acta Obstet Gynecol Scand 2004;83:1193-8. (Pubitemid 39626198)
19. Chen J, Lang JH, Zhu L, et al. Study of morphological changes in levator ani muscle of patients with stress urinary incontinence or pelvic organ prolapse. Zhonghua Fu Chan Ke Za Zhi 2004;39:519-21.
20. Mouritsen L. Classification and evaluation of prolapse. Best Pract Res Clin Obstet Gynaecol 2005;19:895-911. (Pubitemid 43012998)
21. Visco AG, Yuan L. Differential gene expression in pubococcygeus muscle from patients with pelvic organ prolapse. Am J Obstet Gynecol 2003;189:102-12. (Pubitemid 36886532)
22. Liang CC, Huang HY, Tseng LH, Chang SD, Lo TS, Lee CL. Expression of matrix metalloproteinase-2 and tissue inhibitors of metalloproteinase-1 (TIMP-1, TIMP-2 and TIMP-3) in women with uterine prolapse but without urinary incontinence. Eur J Obstet Gynecol Rep Biol 2010;153:94-8.
23. Swift S, Woodman P, O'Boyle A, et al. Pelvic Organ Support Study (POSST): the distribution, clinical definition, and epidemiologic condition of pelvic organ support defects. Am J Obstet Gynecol 2005;192:795-806. (Pubitemid 40311272)
24. Versi E, Harvey MA, Cardozo L, Brincat M, Studd JW. Urogenital prolapse and atrophy at menopause: a prevalence study. Int Urogynecol J Pelvic Floor Dysfunct 2001;12:107-10. (Pubitemid 32451986)