Changes in extracellular matrix proteins in the cardinal ligaments of post-menopausal women with or without prolapse: A computerized immunohistomorphometric analysis

Human Reproduction

Volumn 18, Issue 10, 2003, Pages 2189-2195

  Ewies, Ayman A A ^a   Al Azzawi, Farook ^a   Thompson, John ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Collagens; Elastin; Ligament; Prolapse; Tenascin

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; ELASTIN; ESTRADIOL VALERATE; ESTROGEN; MATRIX PROTEIN; MONOCLONAL ANTIBODY; NORETHISTERONE; PARAFFIN; SEX HORMONE; TENASCIN;

AGE; ARTICLE; CHILDBIRTH; COMPUTER PROGRAM; EXTRACELLULAR MATRIX; FEMALE; HORMONE SUBSTITUTION; HUMAN; HUMAN TISSUE; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; LIGAMENT; MENOPAUSE; MORPHOMETRICS; POSTMENOPAUSE; PROTEIN EXPRESSION; SUPPLEMENTATION; UTERUS PROLAPSE;

EID: 0142134108     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deg420     Document Type: Article

References (36)

1. Benjamin, M. and Ralphs, J.R. (1997) Histol. Histopathol., 12, 1135-1144.
2. Bernstein, E.F., Chen, Y.Q., Tamai, K., Shepley, K.J., Resnik, K.S., Zhang, H., Tuan, R., Mauviel, A. and Uitto, J. (1994) Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. J. Invest. Dermatol., 103, 182-186.
3. Bidmead, J. and Cardozo, L.D. (1998) Pelvic floor changes in the older woman. Br. J. Urol., 82 (Suppl. 1), 18-25.
4. Boreham, M.K., Wai, C.Y., Miller, R.T., Schaffer, J.I. and Word, R.A. (2002) Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. Am. J. Obstet. Gynecol., 187, 56-63.
5. Chadwick, D. and Goode, J. (1995) Ciba Foundation Symposium: The Molecular Biology and Pathology of Elastic Tissues. Wiley, New York.
6. Cleary, E. (1996) Skin. In Comper, W. (ed.), Extracellular Matrix, Volume I: Tissue Function. Harwood, Amsterdam, pp. 77-109.
7. Cooper, R. and Misol, S. (1970) Tendon and ligament insertions. J. Bone Joint Surg., 52, 1-20.
8. Culav, E., Clark, C. and Merrilees, M. (1999) Connective tissues: Matrix composition and its relevance to physical therapy. Phys. Ther., 79, 308-319.
9. Ernst, M., Heath, J.K. and Rodan, G.A. (1989) Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones. Endocrinology, 125, 825-833.
10. Falconer, C., Ekman, G., Malmstrom, A. and Ulmsten, U. (1994) Decreased collagen synthesis in stress-incontinent women. Obstet. Gynecol., 84, 583-586.
11. Fazio, M.J., Olsen, D.R., Kuivaniemi, H., Chu, M.L., Davidson, J.M., Rosenbloom, J. and Uitto, J. (1988) Isolation and characterization of human elastin cDNAs and age-associated variation in elastin gene expression in cultured skin fibroblasts. Lab. Invest., 58, 270-277.
12. Friedman, D., Boyd, C., Norton, P. and Deak, S. (1993) Altered type III collagen synthesis in patients with inguinal hernia. Amer. Surg., 218, 754-760.
13. Hamilton, P. (1995) Designing a morphometric study. In Hamilton, P. and Allen, D. (eds), Quantitative Clinical Pathology. Blackwell, Oxford, pp. 311-315.
14. Hart, D., Frank, C.B. and Bray, R.C. (1995) In Gordon, S., Blair, S. and Fine, L. (eds), Repetitive Motion Disorders of the Upper Extremities. American Academy of Orthopedics Surgeons, Rosemont, pp. 247-262.
15. Hassager, C., Jensen, L., Podenphant, J., Riis, B. and Christiansen, C. (1990) Collagen synthesis in postmenopausal women therapy with anabolic steroid or female sex hormones. Metabolism, 39, 1167-1169.
16. Hassager, C., Jensen, L.T., Johansen, J.S., Riis, B.J., Melkko, J., Podenphant, J., Risteli, L., Christiansen, C. and Risteli, J. (1991) The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: The effect of nandrolone decanoate and female sex hormones. Metabolism, 40, 205-208.
17. Kökcü, A., Yanik, F., Cetinkaya, M., Alper, T., Kandemir, B. and Malatyalioglu, E. (2002) Histopathological evaluation of the connective tissue of the vaginal fascia and the uterine ligaments in women with and without pelvic relaxation. Arch. Gynecol. Obstet., 266, 75-78.
18. Laros, G., Tipton, G. and Cooper, R. (1971) Influence of physical activity on ligament insertions in dogs. J. Bone Joint Surg., 53A, 275-286.
19. Liu, S., Yang, R., Al-Shaikh, R. and Lane, J. (1995) Collagen in tendons, ligaments and bone healing. Clin. Orthopaed., 318, 265-278.
20. MacLennan, A. (2000) The descent of woman. Climacteric, 3, 225-226.
21. Majeska, R.J., Ryaby, J.T. and Einhorn, T.A. (1994) Direct modulation of osteoblastic activity with estrogen. J. Bone Joint Surg. Am., 76, 713-21.
22. Mokrzycki, M., Mittal, K., Smilen, S., Blechman, A., Porges, R. and Demopolous, R. (1997) Estrogen and progerterone receptors in the uterosacral ligament. Obstet. Gynecol., 90, 402-404.
23. Neurath, M. (1993) [Expression of tenascin, laminin and fibronectin following traumatic rupture of the anterior cruciate ligament.] Z. Orthop. Ihre Grenzgeb., 131, 168-172.
24. Norton, P., Boyd, C. and Deak, S. (1992) Collagen synthesis in women with genital prolapse or stress urinary incontinence. Neurol. Urodyn., 11, 300-301.
25. Pierce, R., Mariani, T. and Senior, R. (1995) Elastin in lung development and disease. Chadwick, D. and Goode, J. (eds), Ciba Foundation Symposium: The Molecular Biology and Pathology of Elastic Tissues. 192, pp. 199-212.
26. Savvas, M., Bishop, J., Laurent, G., Watson, N. and Studd, J. (1993) Type III collagen content in the skin of postmenopausal women receiving oestradiol and testosterone implants. Br. J. Obstet. Gynecol., 100, 154-156.
27. Smith, A.R., Hosker, G.L. and Warrell, D.W. (1989) The role of partial denervation of the pelvic floor in the aetiology of genitourinary prolapse and stress incontinence of urine. A neurophysiological study. Br. J. Obstet. Gynecol., 96, 24-28.
28. Uitto, J., Fazio, M., Bashir, M. and Rosenbloom, J. (1991) Elastic fibres of the connective tissue. In Goldsmith, L. (ed.), Physiology, Biochemistry and Molecular Biology of the Skin. Oxford University Press, New York, pp. 533-557.
29. Ulmsten, U., Ekman, G., Giertz, G. and Malmstrom, A. (1987) Different biochemical composition of connective tissue in continent and stress incontinent women. Acta Obstet. Gynecol. Scand., 66, 455-457.
30. Versi, E., Cardozo, L., Brincat, M., Cooper, D., Montgomery, J. and Studd, J. (1988) Correlation of urethral physiology and skin collagen in postmenopausal women. Br. J. Obstet. Gynecol., 95, 147-152.
31. Wahab, M., Thompson, J., Hamid, B., Deen, S. and Al-Azzawi, F. (1999) Endometrial histomorphometry of trimegestone-based sequential hormone replacement therapy: A weighted comparison with the endometrium of the natural cycle. Hum. Reprod., 14, 2609-2618.
32. Wallner, K., Li, C., Shah, P.K., Fishbein, M.C., Forrester, J.S., Kaul, S. and Sharifi, B.G. (1999) Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque. Circulation, 99, 1284-1289.
33. Woo, S.-Y., Ohland, K. and McMahon, P. (1991) Biology, healing and repair of ligaments. In Finerman, G. and Noyes, F. (eds), Biology and Biomechanics of the Traumatized Synovial Joint: The Knee as a Model. American Academy of Orthopedic Surgeons, Rosemont, pp. 241-273.
34. Yamamoto, K., Yamamoto, M., Akazawa, K., Tajima, S., Wakimoto, H. and Aoyagi, M. (1997) Decrease in elastin gene expression and protein synthesis in fibroblasts derived from cardinal ligaments of patients with prolapsus uteri. Cell Biol. Int., 21, 605-611.
35. Yamamoto, M., Aoyagi, M., Akazawa, K., Tajima, S. and Yamamoto, K. (1998) Decrease in P53 protein in cultured cardinal ligament fibroblasts from patients with prolapsus uteri. Cell Biol. Int., 22, 31-40.
36. Yu, W., Liu, S., Hatch, J., Panossian, V. and Finerman, G. (1999) Effect of estrogen on cellular metabolism of the human anterior cruciate ligament. Clin. Orthopaed. Relat. Res., 366, 229-238.