Identification of cytokeratin 18 as a biomarker of mouse and human hepatosplenic schistosomiasis

Infection and Immunity

Volumn 79, Issue 5, 2011, Pages 2051-2058

  Manivannan, Bhagyashree ^a   Rawson, Pisana ^a   Jordan, T William ^a   Karanja, Diana M S ^b   Mwinzi, Pauline N M ^b   Secor, William Evan ^c   La Flamme, Anne Camille ^a  

^a VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^b KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CYTOKERATIN 18; HYDROXYPROLINE; INTERLEUKIN 2; PEROXIREDOXIN 6; PHOSPHOENOLPYRUVATE CARBOXYKINASE (PYROPHOSPHATE);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EARLY DIAGNOSIS; HEPATOMEGALY; HEPATOSPLENIC SCHISTOSOMIASIS; HUMAN; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN URINE LEVEL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SERUM; SPLENOMEGALY; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HEPATOMEGALY; HUMANS; KERATIN-18; LIVER DISEASES, PARASITIC; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED CBA; SCHISTOSOMIASIS; SPLENOMEGALY;

EID: 79955610102     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01214-10     Document Type: Article

References (34)

1. Aitchison, J. 1986. The statistical analysis of compositional data. Chapman and Hall, London, United Kingdom.
2. Andrade, Z. A., E. Peixoto, S. Guerret, and J. Grimaud. 1992. Hepatic connective tissue changes in hepatosplenic schistosomiasis. Hum. Pathol. 23:566-573.
3. Asahi, H., A. Osman, R. M. Cook, P. T. LoVerde, and M. J. Stadecker. 2000. Schistosoma mansoni phosphoenolpyruvate carboxykinase, a novel egg antigen: immunological properties of the recombinant protein and identification of a T-cell epitope. Infect. Immun. 68:3385-3393.
4. Attallah, A. M., et al. 2007. Evaluation of serum procollagen aminoterminal propeptide III, laminin, and hydroxyproline as predictors of severe fibrosis in patients with chronic Hepatitis C. J. Immunoassay Immunochem. 28:199-211.
5. Bastos, R., et al. 1992. Increase of cytokeratin D during liver regeneration: association with the nuclear matrix. Hepatology 16:1434-1446.
6. Beddek, A. J., et al. 2008. Profiling the metabolic proteome of bovine mammary tissue. Proteomics 8:1502-1515.
7. Beynon, R. J., and J. L. Hurst. 2004. Urinary proteins and the modulation of chemical scents in mice and rats. Peptides 25:1553-1563.
8. Cheever, A. W., and M. Barral-Netto. 1985. Fibroblast stimulating activity of extracts of hepatic granulomata of Schistosoma mansoni-infected rodents with marked or slight hepatic fibrosis. Trans. R. Soc. Trop. Med. Hyg. 79:319-321.
9. Chiavaroli, R., and P. Grima. 2008. Detection of early liver fibrosis in patients with intestinal schistosomiasis: sonographic and histologic findings in Schistosoma mansoni infection. Infection 36:585-589.
10. Crompton, D. W. T. 1999. How much human helminthiasis is there in the world? J. Parasitol. 85:397-403.
11. Dessein, A., et al. 2009. Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes. J. Exp. Med. 206:2321-2328.
12. Dunn, M. A., M. Rojkind, and K. S. Warren. 1977. Liver collagen synthesis in murine schistosomiasis. J. Clin. Invest. 59:666-674.
13. Elchuri, S., M. Naeemuddin, O. Sharpe, W. H. Robinson, and T. T. Huang. 2007. Identification of biomarkers associated with the development of hep-atocellular carcinoma in CuZn superoxide dismutase deficient mice. Pro-teomics 7:2121-2129.
14. El-Meneza, S., G. R. Olds, T. F. Kresina, and A. A. F. Mahmoud. 1989. Dynamics of hepatic connective tissue matrix constituents during murine Schistosoma mansoni infection. Hepatology 9:50-56.
15. Elsammak, M. Y., R. M. Al-Sharkaweey, M. S. Ragab, G. A. Amin, and M. H. Kandil. 2008. IL-4 and reactive oxygen species are elevated in Egyptian patients affected with schistosomal liver disease. Parasite Immunol. 30:603-609.
16. George, J., and G. Chandrakasan. 2000. Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine. Clin. Biochem. 33:563-570.
17. Henderson, G. S., et al. 1993. Two distinct pathological syndromes in male CBA/J. inbred mice with chronic Schistosoma mansoni infections. Am. J. Pathol. 142:703-714.
18. Kovalenko, E., et al. 2009. Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. J. Viral Hepatitis 16:612-620.
19. Manivannan, B., P. Rawson, T. W. Jordan, W. E. Secor, and A. C. La Flamme. 2010. Differential patterns of liver proteins in experimental murine hepatosplenic schistosomiasis. Infect. Immun. 78:618-628.
20. Montesano, M. A., D. G. Colley, M. T. Willard, G. L. Freeman Jr., and W. E. Secor. 2002. Idiotypes expressed early in experimental Schistosoma mansoni infections predict clinical outcomes of chronic disease. J. Exp. Med. 195:1223-1228.
21. Mwinzi, P. N. M., et al. 2004. Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodefiency virus 1. Am. J. Trop. Med. Hyg. 71:783-786.
22. Oshima, R. G. 2002. Apoptosis and keratin intermediate filaments. Cell Death Differ. 9:486-492.
23. Richter, J., C. Hatz, G. Campagne, N. R. Bergquist, and J. M. Jenkins. 2000. Ultrasound in schistosomiasis: a practical guide to the standardized use of ultrasonography for the assessment of schistosomiasis-related morbidity. World Health Organization, Geneva, Switzerland.
24. Rumbley, C. A., et al. 1998. The schistosome granuloma: characterization of lymphocyte migration, activation, and cytokine production. J. Immunol. 161: 4129-4137.
25. Salmhofer, H., I. Rainer, K. Zatloukal, and H. Denk. 1994. Posttranslational events involved in griseofulvin-induced keratin cytoskeleton alterations. Hepatology 20:731-740.
26. Strnad, P., et al. 2006. Keratin variants associate with progression of fibrosis during chronic hepatitis C infection. Hepatology 43:1354-1363.
27. Strnad, P., et al. 2008. Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacet-amide models. Gastroenterology 134:1169-1179.
28. Takahashi, S., M. A. Dunn, and S. Seifter. 1980. Liver collagenase in murine schistosomiasis. Gastroenterology 78:1425-1431.
29. Uji, Y., et al. 1994. Measurement of free and total hydroxyproline by automated flow injection of serum or urine samples from maintenance hemodi-alysis patients with renal osteodystrophy. J. Clin. Lab. Anal. 8:267-272.
30. Virtanen, T., and T. Kinnunen. 2008. Mammalian allergens, p. 201-208. In R. F. Lockey and D. K. Ledford (ed.), Allergens and allergen immunother-apy, 4th ed. Informa Health Care, London, United Kingdom.
31. Weng, H.-L., et al. 2007. Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology 46:1257-1270.
32. WHO. 2010, posting date. Schistosomiasis. WHO, Geneva, Switzerland. http://www.who.int/mediacentre/factsheets/fs115/en/index.html.
33. Yang, J., S. C. Kalhan, and R. W. Hanson. 2009. What is the metabolic role of phosphoenolpyruvate carboxykinase? J. Biol. Chem. 284:27025-27029.
34. Zatloukal, K., et al. 2004. The keratin cytoskeleton in liver diseases. J. Pathol. 204:367-376.