Idiotypes expressed early in experimental Schistosoma mansoni infections predict clinical outcomes of chronic disease

Journal of Experimental Medicine

Volumn 195, Issue 9, 2002, Pages 1223-1228

  Angela Montesano, M ^a   Colley, Daniel G ^a   Willard, Margaret T ^a   Freeman Jr , George L ^a   Evan Secor, W ^a,b  

^a NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Fibrosis; Idiotypes; Mice; Schistosomiasis; Splenomegaly

Indexed keywords

IMMUNOGLOBULIN IDIOTYPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS REACTION; EXPERIMENTAL INFECTION; IMMUNOGLOBULIN PRODUCTION; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; OUTCOMES RESEARCH; PATHOLOGY; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SPLENOMEGALY;

ANIMALS; CHRONIC DISEASE; CROSS REACTIONS; DISEASE MODELS, ANIMAL; IMMUNOGLOBULIN IDIOTYPES; MALE; MICE; MICE, INBRED CBA; REGRESSION ANALYSIS; SCHISTOSOMIASIS MANSONI; SPLENOMEGALY; SYNDROME; TIME FACTORS; TREATMENT OUTCOME;

EID: 0037029636     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020329     Document Type: Article

References (30)

1. Spontaneous modulation of granulomatous hypersensitivity in schistosomiasis mansoni
2. Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease
3. Failure of immunosuppressive mechanisms in human Schistosoma mansoni infection with hepatosplenomegaly
4. In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. II. Quantification of IL-4 mRNA, IFN-gamma mRNA, and IL-2 mRNA levels in the granulomatous livers, mesenteric lymph nodes, and spleens during the course of modulation
5. Evolving T cell responses in murine schistosomiasis. Th2 cells mediate secondary granulomatous hypersensitivity and are regulated by CD8+ T cells in vivo
6. The role of cytokines in the formation of the schistosome egg granuloma
7. IL-10 regulates liver pathology in acute murine Schistosoma mansoni but is not required for immune down-modulation of chronic disease
8. Cytokine control of the granulomatous response in Schistosoma mansoni-infected baboons: Role of exposure and treatment
9. Immune responses during human schistosomiasis mansoni. XVI. Idiotypic differences in antibody preparations from patients with different clinical forms of infection
10. Two distinct pathological syndromes in male CBA/J inbred mice with chronic Schistosoma mansoni infections
11. Immunoregulatory idiotypes stimulate T helper 1 cytokine responses in experimental Schistosoma mansoni infections
12. Neonatal idiotypic exposure alters subsequent cytokine, pathology, and survival patterns in experimental Schistosoma mansoni infections
13. Neonatal exposure to idiotype induces Schistosoma mansoni egg antigen-specific cellular and humoral immune responses
14. Network interactions in Schistosoma japonicum infection. Identification and characterization of a serologically distinct immunoregularoty auto-antiidiotypic antibody population
15. Concomitant cellular and humoral expression of a regulatory cross-reactive idiotype in acute Schistosoma japonicum infection
16. Function and expression of a human idiotypic network in Schistosomiasis japonicum
17. Lymphokine regulation of granuloma formation in murine schistosomiasis mansoni
18. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology
19. Cross-regulatory role of interferongamma (IFN-γ). IL-4 and IL-10 in schistosome egg granuloma formation: In vivo regulation of Th activity and inflammation
20. Expression of cross-reactive, shared idiotypes on anti-SEA antibodies from humans and mice with schistosomiasis
21. Early development and progression of lymphocyte-stimulatory cross-reactive idiotypes expressed on antibodies to soluble egg antigens during Schistosoma mansoni infection of mice
22. Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissue
23. Two improved and simplified methods for the spectrophotometric determination of hydroxyproline
24. Treatment with anti-IL-2 antibodies reduces hepatic pathology and eosinophilia in Schistosoma mansoni-infected mice while selectively inhibiting T cell IL-5 production
25. An electrophoretic analysis of Schistosoma mansoni soluble egg antigenic preparation
26. Schistosoma mansoni: Relationship of tumor necrosis factor-α to morbidity and collagen deposition in chronic experimental infection
27. Schistosoma mansoni in the baboon: Modulation of pathology after vaccination with polyclonal anti-idiotypic antibodies
28. FcεRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology
29. + T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling
30. Infection of B-cell -deficient mice by the parasite Schistosoma mansoni: Demonstration of the participation of B cells in granuloma modulation