Simvastatin suppresses expression of angiogenic factors in the retinas of rats with streptozotocin-induced diabetes

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 249, Issue 3, 2011, Pages 389-397

  Lee, Sul Gee ^a   Kim, Jung Lim ^a   Lee, Han Kee ^a   Ryu, Gyu Won ^b   Hur, Dae Young ^c   Yun, Il Han ^a   Yang, Jae Wook ^a   Kim, Hyun Woong ^a,d  

^a Inje University   (South Korea)

^b Balgunoon Ophthalmic Clinic   (South Korea)

^c Inje University College of Medicine   (South Korea)

^d NONE   (South Korea)

Author keywords

Angiopoietin; Erythropoietin; Superoxide; VEGF

Indexed keywords

ANGIOGENIC FACTOR; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ERYTHROPOIETIN; GLUCOSE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SIMVASTATIN; STAT3 PROTEIN; STREPTOZOCIN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DRUG MECHANISM; EYE PROTECTION; GLUCOSE BLOOD LEVEL; IMMUNOFLUORESCENCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANGIOGENIC PROTEINS; ANGIOPOIETIN-1; ANIMALS; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ERYTHROPOIETIN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; NADPH OXIDASE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIMVASTATIN; STAT3 TRANSCRIPTION FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955605807     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-010-1496-5     Document Type: Article

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