Tissue binding affects the kinetics of theophylline diffusion through the stratum corneum barrier layer of skin

Journal of Pharmaceutical Sciences

Volumn 100, Issue 7, 2011, Pages 2989-2995

  Frasch, H Frederick ^a   Barbero, Ana M ^a   Hettick, Justin M ^a   Nitsche, Johannes M ^b  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b State University of New York   (United States)

Author keywords

Keratin; Kinetics; Lag time; Passive diffusion transport; Permeable corneocytes; Protein binding; Reversible binding; Theophylline; Transdermal; Transient diffusion

Indexed keywords

THEOPHYLLINE;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG DIFFUSION; DRUG DISTRIBUTION; EPIDERMIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOTHERM; NONBIOLOGICAL MODEL; PERMEABILITY; SAMPLE SIZE; SOLUTE; STRATUM CORNEUM;

EID: 79955604477     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22489     Document Type: Article

References (16)

1. Frasch HF, Barbero AM. 2008. The transient dermal exposure: Theory and experimental examples using skin and silicone membranes. J Pharm Sci 97:1578-1592.
2. Ho C. 2004. Probabilistic modeling of percutaneous absorption for risk-based exposure assessments and transdermal drug delivery. Stat Methodol 1:47-69.
3. Roberts MS, Anissimov YG. 2005. Mathematical models in percutaneous absorption. In Percutaneous absorption: Drugs-cosmetics-mechanisms-methodology; Bronaugh R, Maibach H, Eds. 4th ed. New York: Marcel Dekker, pp 1-44.
4. Anissimov YG, Roberts MS. 2009. Diffusion modelling of percutaneous absorption kinetics: 4. Effects of a slow equilibration process within stratum corneum on absorption and desorption kinetics. J Pharm Sci 98:772-781.
5. Kortüm G, Vogel W, Andrussow K. 1960. Dissociation constants of organic acids in aqueous solution. Pure Appl Chem 1:187-536.
6. Chakraborty AB, Berger SJ, Gebler JC. 2007. Use of an integrated MS-multiplexed MS/MS data acquisition strategy for high-coverage peptide mapping studies. Rapid Commun Mass Spectrom 21:730-744.
7. Nitsche JM, Wang TF, Kasting GB. 2006. A two-phase analysis of solute partitioning into the stratum corneum. J Pharm Sci 95:649-666.
8. Hansch C, Leo A, Hoekman D. 1995. Exploring QSAR. Hydrophobic, electronic, and steric constants. Washington DC: American Chemical Society.
9. Nitsche JM, Frasch HF. 2011. Dynamics of diffusion with reversible binding in microscopically heterogeneous membranes: General theory and applications to dermal penetration. Chem Eng Sci, in press.
10. Hansen S, Naegel A, Heisig M, Wittum G, Neumann D, Kostka KH, Meiers P, Lehr CM, Schaefer UF. 2009. The role of corneocytes in skin transport revised-A combined computational and experimental approach. Pharm Res 26:1379-1397.
11. Wang TF, Kasting GB, Nitsche JM. 2007. A multiphase microscopic diffusion model for stratum corneum permeability. II. Estimation of physicochemical parameters, and application to a large permeability database. J Pharm Sci 96:3024-3051.
12. Barbero AM, Frasch HF. 2006. Transcellular route of diffusion through stratum corneum: Results from finite element models. J Pharm Sci 95:2186-2194.
13. Siegel RA. 2005. Characterization of relaxation to steady state in membranes with binding and reaction. J Membr Sci 251:91-99.
14. Kasting GB, Barai ND, Wang TF, Nitsche JM. 2003. Mobility of water in human stratum corneum. J Pharm Sci 92:2326-2340.
15. Anderson BD, Raykar PV. 1989. Solute structure-permeability relationships in human stratum-corneum. J Invest Dermatol 93:280-286.
16. Wang L, Chen L, Lian G, Han L. 2010. Determination of partition and binding properties of solutes to stratum corneum. Int J Pharm 398:114-122.