The acute toxicity and hematological characterization of the effects of tentacle-only extract from the jellyfish Cyanea capillata

Marine Drugs

Volumn 9, Issue 4, 2011, Pages 526-534

  Xiao, Liang ^a   Liu, Sihua ^a   He, Qian ^a   Wang, Qianqian ^a   Ye, Xuting ^a   Liu, Guoyan ^a   Nie, Fei ^a   Zhao, Jie ^a   Zhang, Liming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cyanea capillata; Hematological; Jellyfish; Tentacle only extract; Toxic symptom

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CALCIUM ION; CREATINE KINASE; CREATINE KINASE MB; CREATININE; GLUCOSE; HEMOGLOBIN; JELLYFISH VENOM; LACTATE DEHYDROGENASE; LACTIC ACID; POTASSIUM ION; SODIUM ION; UNCLASSIFIED DRUG; VENOM;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTICLE; BLOOD TOXICITY; CARDIOTOXICITY; CONTROLLED STUDY; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; IN VIVO STUDY; LD 50; LIVER TOXICITY; MALE; MOUSE; MUSCLE DISEASE; NEPHROTOXICITY; NEUROTOXICITY; NONHUMAN; PANCREAS DISEASE; PH; POISONOUS JELLYFISH; RAT; UREA NITROGEN BLOOD LEVEL;

CYANEA CAPILLATA; MUS; RATTUS; SCYPHOZOA;

EID: 79955603393     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md9040526     Document Type: Article

References (21)

1. Burnett, J.W. Medical aspects of jellyfish envenomation, pathogenesis, case reporting and therapy. Hydrobiologia 2001, 451, 1-9. (Pubitemid 32972461)
2. Tibballs, J. Australian venomous jellyfish, envenomation syndromes, toxins and therapy. Toxicon 2006, 48, 830-859.
3. Brinkman, D.L.; Burnell, J.N. Biochemical and molecular characterization of cubozoan protein toxins. Toxicon 2009, 54, 1162-1173.
4. Suput, D. In vivo effects of cnidarian toxins and venoms. Toxicon 2009, 54, 1190-1200.
5. Nie, F.; Xiao, L.; Zhang, J.; He, Q.; Fan, J.W.; Li, Y.; Zhang, L.M. Comparison of haemolytic activities of venom separations from jellyfish Cyanea capillata and their influencing factors. Acad. J. Sec. Mil. Med. Univ. 2008, 29, 83-86.
6. Xiao, L.; Guo, Y.F.; Zhang, J.; He, Q.; Nie, F.; Li, Y.; Ye, X.F.; Zhang, L.M. Bioactive analysis of tentacle-only extract from jellyfish Cyanea capillata. Chin. J. Mar. Drugs 2008, 27, 23-27.
7. Xiao, L.; He, Q.; Guo, Y.F.; Zhang, J.; Nie, F.; Li, Y.; Ye, X.F.; Zhang, L.M. Cyanea capillata tentacle-only extract as a potential alternative of nematocyst venom: Its cardiovascular toxicity and tolerance to isolation and purification procedures. Toxicon 2009, 53, 146-152.
8. Xiao, L.; Liu, G.S.; Wang, Q.Q.; He, Q.; Liu, S.H.; Li, Y.; Zhang, J.; Zhang, L.M. The lethality of tentacle-only extract from jellyfish Cyanea capillata is primarily attributed to cardiotoxicity in anaesthetized SD rats. Toxicon 2010, 55, 838-845.
9. Xiao, L.; Zhang, J.; Wang, Q.; He, Q.; Liu, S.; Li, Y.; Zhang, L. In vitro and in vivo haemolytic studies of tentacle-only extract from jellyfish Cyanea capillata. Toxicol. in Vitro 2010, 24, 1203-1207.
10. Ge, L.J.; He, D.M. The marking signal of ecosystem crisis. China Fish. 2004, 9, 23-25.
11. Edwards, L.; Luo, E.; Hall, R.; Gonzalez, R.R.; Hessinger, D.A. The effect of Portuguese Man-of-war (Physalia physalis) venom on calcium, sodium and potassium fluxes of cultured embryonic chick heart cells. Toxicon 2000, 38, 323-335. (Pubitemid 29531574)
12. Edwards, L.; Hessinger, D.A. Portuguese Man-of-war (Physalia physalis) venom induces calcium influx into cells by permeabilizing plasma membranes. Toxicon 2000, 38, 1015-1028.
13. Edwards, L.P.; Whitter, E.; Hessinger, D.A. Apparent membrane pore-formation by Portuguese Man-of-war (Physalia physalis) venom in intact cultured cells. Toxicon 2002, 40, 1299-1305. (Pubitemid 35239900)
14. Houck, H.E.; Lipsky, M.M.; Marzella, L.; Burnett, J.W. Toxicity of sea nettle (Chrysaora quinquecirrha) fishing tentacle nematocyst venom in cultured rat hepatocytes. Toxicon 1996, 34, 771-778.
15. Cao, C.J.; Eldefrawi, M.E.; Eldefrawi, A.T.; Burnett, J.W.; Mioduszewski, R.J.; Menking, D.E.; Valdes, J.J. Toxicity of sea nettle toxin to human hepatocytes and the protective effects of phosphorylating and alkylating agents. Toxicon 1998, 36, 269-281. (Pubitemid 28218622)
16. Winter, K.L.; Isbister, G.K.; Schneider, J.J.; Konstantakopoulos, N.; Seymour, J.E.; Hodgson, W.C. An examination of the cardiovascular effects of an 'Irukandji' jellyfish, Alatina nr mordens. Toxicol. Lett. 2008, 179, 118-123.
17. Ramasamy, S.; Isbister, G.K.; Seymour, J.E.; Hodgson, W.C. Pharmacologically distinct cardiovascular effects of box jellyfish (Chironex fleckeri) venom and a tentacle-only extract in rats. Toxicol. Lett. 2005, 155, 219-226. (Pubitemid 39643207)
18. Ramasamy, S.; Isbister, G.K.; Seymour, J.E.; Hodgson, W.C. The in vivo cardiovascular effects of the Irukandji jellyfish (Carukia barnesi) nematocyst venom and a tentacle extract in rats. Toxicol. Lett. 2005, 155, 135-141.
19. Bloom, D.A.; Burnett, J.W.; Alderslade, P. Partial purification of box jellyfish (Chironex fleckeri) nematocyst venom isolated at the beachside. Toxicon 1998, 36, 1075-1085. (Pubitemid 28302720)
20. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 1976, 72, 248-254.
21. El-Sayed, Y.S.; Khalil, R.H.; Saad, T.T. Acute toxicity of ochratoxin-A in marine water-reared sea bass (Dicentrarchus labrax L.). Chemosphere 2009, 75, 878-882.