The in vivo cardiovascular effects of the Irukandji jellyfish (Carukia barnesi) nematocyst venom and a tentacle extract in rats

Toxicology Letters

Volumn 155, Issue 1, 2005, Pages 135-141

  Ramasamy, Sharmaine ^a   Isbister, Geoffrey K ^a   Seymour, Jamie E ^b   Hodgson, Wayne C ^a  

^a MONASH UNIVERSITY   (Australia)

^b JAMES COOK UNIVERSITY   (Australia)

Author keywords

Carukia barnesi; Catecholamines; In vivo; Irukandji; Jellyfish; Venom

Indexed keywords

CATECHOLAMINE; COELENTERATE VENOM; JELLYFISH VENOM; PHENYLEPHRINE; PRAZOSIN; UNCLASSIFIED DRUG;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ARTICLE; CARDIOGENIC SHOCK; CARDIOVASCULAR EFFECT; CATECHOLAMINE RELEASE; CONTROLLED STUDY; DRUG POTENTIATION; ENVENOMATION; HEART VENTRICLE TACHYCARDIA; JELLYFISH; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT;

ANIMALIA; CARUKIA BARNESI; SCYPHOZOA;

EID: 10044278131     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2004.09.004     Document Type: Article

References (27)

1. P.M. Bailey, M. Little, G.A. Jelinek, and J.A. Wilce Jellyfish envenoming syndromes: unknown toxic mechanisms and unproven therapies Med. J. Aust. 178 2003 34 37
2. J.H. Barnes Cause and effect of Irukandji stingings Med. J. Aust. I 1964 897 904
3. D.A. Bloom, J.W. Burnett, and P. Alderslade Partial purification of box jellyfish (Chironex fleckeri) nematocyst venom isolated at the beachside Toxicon 36 1998 1075 1085
4. T. Carrette, and J.E. Seymour A rapid and repeatable method for the extraction of venom from the Cubozoan nematocysts Toxicon 44 2004 135 139
5. M.M. Corrêa, S.V. Sampaio, R.A. Lopes, L.C. Mancuso, O.A. Cunha, J.J. Franco, and J.R. Giglio Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin: Part-I Toxicon 35 1997 1053 1067
6. R. Endean Separation of two myotoxins from nematocysts of the box jellyfish (Chironex fleckeri) Toxicon 25 1987 483 492
7. R. Endean, and M. Noble Toxic material from the tentacles of the cubomedusan Chironex fleckeri Toxicon 9 1971 255 264
8. P. Fenner, D. Rodgers, and J. Williamson Box jellyfish antivenom and "Irukandji" stings Med. J. Aust. 144 1986 665 666
9. P.J. Fenner, and J.C. Hadok Fatal envenomation by jellyfish causing Irukandji syndrome Med. J. Aust. 177 2002 362 363
10. P.J. Fenner, J. Williamson, V.I. Callanan, and I. Audley Further understanding of, and a new treatment for "Irukandji" (Carukia barnesi) stings Med. J. Aust. 145 569 1986 572 574
11. P.J. Fenner, J.A. Williamson, J.W. Burnett, D.M. Colquhoun, S. Godfrey, K. Gunawardane, and W. Murtha The "Irukandji syndrome" and acute pulmonary oedema Med. J. Aust. 149 1988 150 156
12. J.L. Holmes Marine stingers in far North Queensland Aust. J. Dermatol. 37 Suppl. 1 1996 23 26
13. T.T. Huynh, J. Seymour, P. Pereira, R. Mulcahy, P. Cullen, T. Carrette, and M. Little Severity of Irukandji syndrome and nematocyst identification from skin scrapings Med. J. Aust. 178 2003 38 41
14. M. Little, and R.F. Mulcahy A year's experience of Irukandji envenomation in far North Queensland Med. J. Aust. 169 1998 638 641
15. M. Little, R.F. Mulcahy, and D.J. Wenck Life-threatening cardiac failure in a healthy young female with Irukandji syndrome Anaesth. Intensive Care 29 2001 178 180
16. M. Little, P. Pereira, R. Mulcahy, P. Cullen, T. Carrette, and J. Seymour Severe cardiac failure associated with presumed jellyfish sting Irukandji syndrome? Anaesth. Intensive Care 31 2003 642 647
17. M. Little, and J. Seymour Another cause of "Irukandji stingings" Med. J Aust. 179 2003 654
18. H. Nagai, K. Takuwa, M. Nakao, E. Ito, M. Miyake, M. Noda, and T. Nakajima Novel proteinaceous toxins from the box jellyfish (sea wasp) Carybdea rastoni Biochem. Biophys. Res. Commun. 275 2000 582 588
19. H. Nagai, K. Takuwa, M. Nakao, B. Sakamoto, G.L. Crow, and T. Nakajima Isolation and characterization of a novel protein toxin from the Hawaiian box jellyfish (sea wasp) Carybdea alata Biochem. Biophys. Res. Commun. 275 2000 589 594
20. S. Ramasamy, G.K. Isbister, J.E. Seymour, and W.C. Hodgson The in vitro effects of two chirodropid (Chironex fleckeri and Chiropsalmus sp.) venoms: efficacy of box jellyfish antivenom Toxicon 41 2003 703 711
21. S. Ramasamy, G.K. Isbister, J.E. Seymour, and W.C. Hodgson The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats: efficacy of pre-treatment with antivenom, verapamil and magnesium sulphate Toxicon 43 2004 685 690
22. Ramasamy, S., Isbister, G.K., Seymour, J.E., Hodgson, W.C., 2004b. Pharmacologically distinct cardiovascular effects of box jellyfish (Chironex fleckeri) venom and a tentacle-only extract in rats. Toxicol. Letters, in press.
23. A.M. Salam, H.A. Albinali, A.A. Gehani, and J. Al Suwaidi Acute myocardial infarction in a professional diver after jellyfish sting Mayo. Clin. Proc. 78 2003 1557 1560
24. J. Tibballs, G. Hawdon, and K. Winkel Mechanism of cardiac failure in Irukandji syndrome and first aid treatment for stings Anaesth. Intensive Care 29 2001 552
25. J. Williamson, P. Fenner, J.W. Burnett, and J.F. Rifkin Venomous and Poisonous Marine Animals 1996 University of New South Wales Press Sydney
26. C.J. Wiltshire, S.K. Sutherland, P.J. Fenner, and A.R. Young Optimization and preliminary characterization of venom isolated from 3 medically important jellyfish: the box (Chironex fleckeri), Irukandji (Carukia barnesi), and blubber (Catostylus mosaicus) jellyfish Wilderness Environ. Med. 11 2000 241 250
27. M. Zhang, Y. Fishman, D. Sher, and E. Zlotkin Hydralysin, a novel animal group-selective paralytic and cytolytic protein from a noncnidocystic origin in hydra Biochemistry 42 2003 8939 8944