Peripubertal exposure to low doses of tributyltin chloride affects the homeostasis of serum T, E2, LH, and body weight of male mice

Environmental Toxicology

Volumn 26, Issue 3, 2011, Pages 307-314

  Si, Jiliang ^a   Wu, Xuesen ^b   Wan, Chengen ^a   Zeng, Tao ^a   Zhang, Miao ^a   Xie, Keqin ^a   Li, Jie ^a  

^a SHANDONG UNIVERSITY   (China)

^b BENGBU MEDICAL COLLEGE   (China)

Author keywords

Endocrine disruptors; Hormone; Low dose; Mouse; Organotin

Indexed keywords

BODY WEIGHT; DIFFERENT EFFECTS; DOSE-DEPENDENT; ENDOCRINE DISRUPTION; ENDOCRINE DISRUPTOR; LATE STAGE; LOW DOSE; LOW LEVEL; MALE MOUSE; MOUSE; ORGANOTINS; PHYSIOLOGIC PARAMETERS; TESTOSTERONE; TRIBUTYLTIN; TRIBUTYLTIN CHLORIDES;

ANTHROPOMETRY; CHLORINE COMPOUNDS; MAMMALS; ORGANOMETALLICS; PHYSIOLOGY;

BODY FLUIDS;

ESTRADIOL; LUTEINIZING HORMONE; TESTOSTERONE; TRIBUTYLTIN CHLORIDE;

DOSE-RESPONSE RELATIONSHIP; ENDOCRINE DISRUPTOR; EXPERIMENTAL STUDY; HOMEOSTASIS; HORMONE; MALE; ORGANIC COMPOUND; PARAMETERIZATION; RODENT; WEIGHT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; HOMEOSTASIS; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MOUSE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PUBERTY; TESTOSTERONE BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; EPIDIDYMIS; ESTRADIOL; HOMEOSTASIS; KIDNEY; LIVER; LUTEINIZING HORMONE; MALE; MICE; ORGAN SIZE; PUBERTY; SPLEEN; TESTIS; TESTOSTERONE; THYMUS GLAND; TRIALKYLTIN COMPOUNDS; WEIGHT GAIN;

ANIMALIA; MAMMALIA; MUS; RODENTIA;

EID: 79955601702     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20560     Document Type: Article

References (49)

1. Adeeko A, Li D, Forsyth DS, Casey V, Cooke GM, Barthelemy J, Cyr DG, Trasler JM, Robaire B, Hales BF. 2003. Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome. Toxicol Sci 74: 407-415.
2. Akingbemi BT, Ge R, Klinefelter GR, Zirkin BR, Hardy MP. 2004a. Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proc Natl Acad Sci USA 101: 775-780.
3. Akingbemi BT, Sottas CM, Koulova AI, Klinefelter GR, Hardy MP. 2004b. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 145: 592-603.
4. Antizar-Ladislao B. 2008. Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment: A review. Environ Int 34: 292-308.
5. Auger AP, Tetel MJ, McCarthy MM. 2000. Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. Proc Natl Acad Sci USA 97: 7551-7555.
6. Bonefeld-Jorgensen EC, Long M, Hofmeister MV, Vinggaard AM. 2007. Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: New data and a brief review. Environ Health Perspect 115 Suppl 1: 69-76.
7. Chen Y, Zuo Z, Chen S, Yan F, Yang Z, Wang C. 2008. Reduction of spermatogenesis in mice after tributyltin administration. Toxicology 251: 21-27.
8. Cohen J. 2003. Endocrine disrupters. Lab accident reveals potential health risks of common compound. Science 300: 31-32.
9. Cooke GM, Tryphonas H, Pulido O, Caldwell D, Bondy GS, Forsyth D. 2004. Oral (gavage), in utero and postnatal exposure of Sprague-Dawley rats to low doses of tributyltin chloride. I. Toxicology, histopathology and clinical chemistry. Food Chem Toxicol 42: 211-220.
10. Grote K, Stahlschmidt B, Talsness CE, Gericke C, Appel KE, Chahoud I. 2004. Effects of organotin compounds on pubertal male rats. Toxicology 202: 145-158.
11. Heindel JJ. 2003. Endocrine disruptors and the obesity epidemic. Toxicol Sci 76: 247-249.
12. Hess RA, Bunick D, Lee KH, Bahr J, Taylor JA, Korach KS, Lubahn DB. 1997. A role for oestrogens in the male reproductive system. Nature 390: 509-512.
13. Horiguchi T. 2006. Masculinization of female gastropod mollusks induced by organotin compounds, focusing on mechanism of actions of tributyltin and triphenyltin for development of imposex. Environ Sci 13: 77-87.
14. Horiguchi T, Kojima M, Hamada F, Kajikawa A, Shiraishi H, Morita M, Shimizu M. 2006. Impact of tributyltin and triphenyltin on ivory shell (Babylonia japonica) populations. Environ Health Perspect 114 (Suppl 1): 13-19.
15. Hotchkiss AK, Rider CV, Blystone CR, Wilson VS, Hartig PC, Ankley GT, Foster PM, Gray CL, Gray LE. 2008. Fifteen years after "Wingspread" environmental endocrine disrupters and human and wildlife health: Where we are today and where we need to go. Toxicol Sci 105: 235-259.
16. Howdeshell KL, Hotchkiss AK, Thayer KA, Vandenbergh JG, vom Saal FS. 1999. Exposure to bisphenol A advances puberty. Nature 401: 763-764.
17. Jiang B, Mendelson CR. 2005. O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2. Mol Cell Biol 25: 8824-8833.
18. Kaiser J. 2000. Endocrine disrupters. Panel cautiously confirms low-dose effects. Science 290: 695-697.
19. Kaiser J. 2003. Hormesis. Sipping from a poisoned chalice. Science 302: 376-379.
20. Kaiser J. 2007. Endocrine disrupters. Controversy continues after panel rules on bisphenol A. Science 317: 884-885.
21. Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway. Mol Pharmacol 67: 766-774.
22. Kannan K, Senthilkumar K, Giesy JP. 1999. Occurrence of butyltin compounds in human blood. Environ Sci Technol 33: 1776-1779.
23. Keith SW, Redden DT, Katzmarzyk PT, Boggiano MM, Hanlon EC, Benca RM, Ruden D, Pietrobelli A, Barger JL, Fontaine KR, et al. 2006. Putative contributors to the secular increase in obesity: Exploring the roads less traveled. Int J Obes (Lond) 30: 1585-1594.
24. Kimbrough RD. 1976. Toxicity and health effects of selected organotin compounds: A review. Environ Health Perspect 14: 51-56.
25. Krajnc EI, Wester PW, Loeber JG, van Leeuwen FX, Vos JG, Vaessen HA, van der Heijden CA. 1984. Toxicity of bis(tri-n-butyltin)oxide in the rat. I. Short-term effects on general parameters and on the endocrine and lymphoid systems. Toxicol Appl Pharmacol 75: 363-386.
26. Matsumiya K, Meistrich ML, Shetty G, Dohmae K, Tohda A, Okuyama A, Nishimune Y. 1999. Stimulation of spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mutant mice by gonadotropin-releasing hormone antagonist treatment. Endocrinology 140: 4912-4915.
27. McVey MJ, Cooke GM. 2003. Inhibition of rat testis microsomal 3beta-hydroxysteroid dehydrogenase activity by tributyltin. J Steroid Biochem Mol Biol 86: 99-105.
28. Melnick R, Lucier G, Wolfe M, Hall R, Stancel G, Prins G, Gallo M, Reuhl K, Ho SM, Brown T, et al. 2002. Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review. Environ Health Perspect 110: 427-431.
29. Nakanishi T, Nishikawa J, Hiromori Y, Yokoyama H, Koyanagi M, Takasuga S, Ishizaki J, Watanabe M, Isa S, Utoguchi N, et al. 2005. Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. Mol Endocrinol 19: 2502-2516.
30. Newbold RR, Padilla-Banks E, Jefferson WN, Heindel JJ. 2008. Effects of endocrine disruptors on obesity. Int J Androl 31: 201-208.
31. O'Donnell L, Robertson KM, Jones ME, Simpson ER. 2001. Estrogen and spermatogenesis. Endocrinol Rev 22: 289-318.
32. Oetken M, Bachmann J, Schulte-Oehlmann U, Oehlmann J. 2004. Evidence for endocrine disruption in invertebrates. Int Rev Cytol 236: 1-44.
33. Ohno S, Nakajima Y, Nakajin S. 2005. Triphenyltin and Tributyltin inhibit pig testicular 17beta-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis. Steroids 70: 645-651.
34. Omura M, Ogata R, Kubo K, Shimasaki Y, Aou S, Oshima Y, Tanaka A, Hirata M, Makita Y, Inoue N. 2001. Two-generation reproductive toxicity study of tributyltin chloride in male rats. Toxicol Sci 64: 224-232.
35. Robertson KM, O'Donnell L, Jones ME, Meachem SJ, Boon WC, Fisher CR, Graves KH, McLachlan RI, Simpson ER. 1999. Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene. Proc Natl Acad Sci USA 96: 7986-7991.
36. Rubin BS, Murray MK, Damassa DA, King JC, Soto AM. 2001. Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect 109: 675-680.
37. Saitoh M, Yanase T, Morinaga H, Tanabe M, Mu YM, Nishi Y, Nomura M, Okabe T, Goto K, Takayanagi R, et al. 2001. Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN. Biochem Biophys Res Commun 289: 198-204.
38. Satoh K, Nagai F, Aoki N. 2001. Several Environmental pollutants have binding affinities for both androgen receptor and estrogen receptor alpha. J Health Sci 47: 495-501.
39. Shetty G, Wilson G, Huhtaniemi I, Boettger-Tong H, Meistrich ML. 2001. Testosterone inhibits spermatogonial differentiation in juvenile spermatogonial depletion mice. Endocrinology 142: 2789-2795.
40. Shi G, Chen D, Zhai G, Chen MS, Cui QC, Zhou Q, He B, Dou QP, Jiang G. 2009. The proteasome is a molecular target of environmental toxic organotins. Environ Health Perspect 117: 379-386.
41. Simpson ER, Davis SR. 2000. Another role highlighted for estrogens in the male: Sexual behavior. Proc Natl Acad Sci USA 97: 14038-14040.
42. Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ito Y, Fisher CR, Michael MD, et al. 1994. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocrinol Rev 15: 342-355.
43. Simpson ER, Misso M, Hewitt KN, Hill RA, Boon WC, Jones ME, Kovacic A, Zhou J, Clyne CD. 2005. Estrogen-The good, the bad, and the unexpected. Endocrinol Rev 26: 322-330.
44. Snoeij NJ, Penninks AH, Seinen W. 1987. Biological activity of organotin compounds-An overview. Environ Res 44: 335-353.
45. Takahashi S, Mukai H, Tanabe S, Sakayama K, Miyazaki T, Masuno H. 1999. Butyltin residues in livers of humans and wild terrestrial mammals and in plastic products. Environ Pollut 106: 213-218.
46. Tessier E, Amouroux D, Morin A, Christian L, Thybaud E, Vindimian E, Donard OF. 2007. (Tri)butyltin biotic degradation rates and pathways in different compartments of a freshwater model ecosystem. Sci Total Environ 388: 214-233.
47. vom Saal FS, Timms BG, Montano MM, Palanza P, Thayer KA, Nagel SC, Dhar MD, Ganjam VK, Parmigiani S, Welshons WV. 1997. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci USA 94: 2056-2061.
48. Welshons WV, Thayer KA, Judy BM, Taylor JA, Curran EM, vom Saal FS. 2003. Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Environ Health Perspect 111: 994-1006.
49. Zhao H, Innes J, Brooks DC, Reierstad S, Yilmaz MB, Lin Z, Bulun SE. 2009. A novel promoter controls Cyp19a1 gene expression in mouse adipose tissue. Reprod Biol Endocrinol 7: 37.