The proteasome is a molecular target of environmental toxic organotins

Environmental Health Perspectives

Volumn 117, Issue 3, 2009, Pages 379-386

  Shi, Guoqing ^a,b,c   Chen, Di ^b   Zhai, Guangshu ^a   Chen, Marina S ^b   Cui, Qiuzhi Cindy ^b   Zhou, Qunfang ^a   He, Bin ^a   Dou, Q Ping ^b   Jiang, Guibin ^a  

^a RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

^b WAYNE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY BEIJING   (China)

Author keywords

Cell death; Molecular target; Organotins; Proteasome; Proteasome inhibitors; TPT

Indexed keywords

CASPASE 3; I KAPPA B ALPHA; ORGANOTIN COMPOUND; PROTEASOME; PROTEIN BAX; TRIPHENYLTIN;

ARTICLE; CELL DEATH; CHEMICAL ANALYSIS; CHEMICAL INTERACTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEINASE INHIBITION; TARGET CELL; UBIQUITINATION;

BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; ENVIRONMENTAL POLLUTANTS; HUMANS; IN SITU NICK-END LABELING; JURKAT CELLS; MASS SPECTROMETRY; ORGANOTIN COMPOUNDS; PROTEASOME ENDOPEPTIDASE COMPLEX;

INVERTEBRATA; VERTEBRATA;

EID: 64049101630     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11865     Document Type: Article

References (35)

1. An B, Goldfarb RH, Siman R, Dou QP. 1998. Novel dipeptidyl proteasome inhibitors overcome BcI-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ 5:1062-1075.
2. Burda K, Lekki J, Cieslak J. Kruk J, Lekka M, Dubiel S, et al. 2002. Molecular mechanism of haemolysis induced by triphenyltin chlorido. Appl Organomet Chem 16:148-154.
3. Chen D, Chen MS, Cui QC, Yang H, Dou QP. 2007. Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells. Front Biosci 12:1935-1945.
4. Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR, Dou QP. 2005. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem Pharmacol 69:1421-1432.
5. Ciechanover A. 1998. The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J 17:7151-7160.
6. Dou QP, Li B. 1999. Proteasome inhibitors as potential novel anticancer agents. Drug Resist Updat 2:215-223.
7. Fent K. 1996. Ecotoxicology of organotin compounds. Crit Rev Toxicol 26:1-117.
8. Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL. 1995. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268:726-731.
9. Gao G, Dou QP, 2000. N-terminal cleavage of bax by calpain generates a potent proapoptatic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death. J Cell Biochem 80:53-72.
10. Goldberg AL. 1995. Functions of the proteasome: the lysis at the end of the tunnel, Science 268:522-523.
11. Groll M, Ditzel L, Lowe J, Stock D, Bochtler M, Bartunik HD, et al. 1997. Structure of 20S proteasome from yeast at 2.4 Å resolution. Nature 386:463-471.
12. Grun F, Watanabe H, Zamanian Z, Maeda L, Arima K, Cubacha R, et al. 2006. Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Mol Endocrinol 20:2141-2155.
13. Harino H, Ohji M, Wattayakorn G, Adulyanukosol K, Arai T, Miyazaki N. 2007. Accumulation of organotin compounds in tissues and organs of stranded whales along the coasts of Thailand. Arch Environ Contam Toxicol 53:119-125.
14. Jiang B, Mendelson CR. 2005. O2 enhancement of human trophoblast differentiation and hCYP19 (aromatase) gene expression are mediated by proteasomal degradation of USF1 and USF2. Mol Cell Biol 25:8824-8833.
15. Kannan K, Senthilkumar K, Giesy JP. 1999. Occurrence of butyltin compounds in human blood. Environ Sci Technol 33:1776-1179.
16. Li B, Dou QP. 2000. Bax degradation by the ubiquitin/ proteasome-dependent pathway: involvement in tumor survival and progression. Proc Natl Acad Sci USA 97:3850-3855.
17. Lopes UG, Erhardt P, Yao R, Cooper GM. 1997, p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem 273:12893-12896.
18. Marinovich M, Viviani B, Corsini E, Ghilardi F, Galli CL. 1996. NF-kappaB activation by triphenyltin triggers apoptosis in HL-60 cells. Exp Cell Res 226:98-104.
19. McAllister BG, Kime DE. 2003. Early life exposure to environmental levels of the aromatase inhibitor tributyltin causes masculinisation and irreversible sperm damage in zebrafish (Danio rerio). Aquat Toxicol 65:309-316.
20. Mundy WR, Freudenrich TM. 2006. Apoptosis of cerebellar granule cells induced by organotin compounds found in drinking water: involvement of MAP kinases. Neurotoxicology 27:71-81.
21. Nakatsu Y, Kotake Y, Komasaka K, Hakozaki H, Taguchi R, Kume T, et al. 2006. Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons. Toxicol Sci 89:235-242.
22. Ohhira S, Enomoto M, Matsui H. 2006. In vitro metabolism of tributyltin and triphenyltin by human cytochrome P-450 isotorms. Toxicology. 228:171-177.
23. Pink JJ, Wuerzberger-Davis S, Tagliarino C, Planchon SM, Yang X, Froelich CJ, et al. 2000. Activation of a cysteine protease.in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis. Exp Cell Res 255:144-155.
24. RCSB Protein Data Bank. 2008. An Information Portal to Biological Macromolecular Structures. Availarble: http://www.rcsb.org/pdb/explore/ explore.do?structure-Id=1JD2 [accessed 9 February 2009].
25. Smith DM, Daniel KG, Wang Z, Guida WC, Chan TH, Dou QP. 2004. Docking studies and model development of tea polyphenol proteasome inhibitors: applications to rational drug design. Proteins 54:58-70.
26. Smith P. 1996. Selective decline in imposex levels in the dog-whelk Lepsiella scabina following a ban on the use of TBT antifoulants in New Zealand. Mar Pollut Bull 32:362-365.
27. Snoeij NJ, Penninks AH, Seinen W. 1987. Biological activity of organotin compounds - an overview. Environ Res 44:335-353.
28. Spooner N, GP, Bryan GW, Goad LJ. 1991, The effect of tributyltin upon steroid titres in the female dogwhelk, Nucella lapillus, and the development of imposex. Mar Environ Res 32:37-49.
29. Strand J, Larsen MM, Lockyer C. 2005. Accumulation of organotin compounds and mercury in harbour porpoises (Phocoena phocoena) from the Danish waters and West Greenland. Sci Total Environ 350:59-71.
30. Stridh, H, Orrenius B, Hampton MB. 1999. Caspase involvement in the induction of apoptosis by the enviromental toxicants tributyltin and triphenyltin. Taxicol Appl Pharmacol 156; 141-146.
31. The Scripps Research Institute. 2008. AutoDock. Available: http://autodock scripps.edu [accessed 9 February 2009].
32. Vicentini CB, Guarneri M, Andrisano V, Guccione S, Langer T, Marschhofer R, et al. 2001. Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors. J Enzyme Inhib 16:15-34.
33. White JS, Tobin JM. 2004. Role of speciation organotin toxicity to the yeast Candida maltosa. Environ Sci Technol
34. Wood DE, Newcomb EW. 2000. Cleavage of Bax enhances its cell death function. Exp Cell Res 256:375-382.
35. Zhu X, Xing M, Lou J, Wang X, Fu W, Xu L. 2007. Apoptotic related biochemical changes in human amnion cells induced by tributyltin. Toxicology 230:45-52.