Activated protein C alters inflammation and protects renal function in sepsis

Journal of Surgical Research

Volumn 168, Issue 1, 2011, Pages

  Keller, Steven A ^a   Moore, Cathy C ^a   Evans, Susan L ^a   McKillop, Iain H ^a   Huynh, Toan ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

Author keywords

activated protein C; interferon ; interleukin 1 ; interleukin 10; renal failure; sepsis

Indexed keywords

ACTIVATED PROTEIN C; CREATININE; ELECTROLYTE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL PROTECTION; SEPSIS; SHAM PROCEDURE; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD UREA NITROGEN; CECUM; CREATININE; DISEASE MODELS, ANIMAL; INFUSIONS, INTRAVENOUS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-1BETA; KIDNEY; LIGATION; MALE; NEPHRITIS; PROTEIN C; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; TREATMENT OUTCOME;

EID: 79955585413     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.01.008     Document Type: Article

References (26)

1. Vincent JL, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med 2006;34:344.
2. Ince C. The microcirculation is the motor of sepsis. Crit Care 2005;9:S13.
3. Doi K, Leelahavanichkul A, Yuen PS, et al. Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest 2009;119:2868.
4. Schrier RW, Wang W. Acute renal failure and sepsis. N Engl J Med 2004;351:159.
5. Esmon CT. Inflammation and the activated protein C anticoagulant pathway. Semin Thromb Hemost 2006;32(suppl 1):49.
6. Conkling PR, Greenberg CS, Weinberg JB. Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes. Blood 1988;72:128.
7. Stouthard JM, Levi M, Hack CE, et al. Interleukin-6 stimulates coagulation, not fibrinolysis, in humans. Thromb Haemost 1996;76:738.
8. Fisher CJ Jr, Yan SB. Protein C levels as a prognostic indicator of outcome in sepsis and related diseases. Crit Care Med 2000;28:S49.
9. Joyce DE, Gelbert L, Ciaccia A, et al. Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001;276:11199.
10. Huynh T, Nguyen N, Keller S, et al. Reducing leukocyte trafficking preserves hepatic function after sepsis. J Trauma 2010;69:360.
11. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303.
12. Thijs A, Thijs LG. Pathogenesis of renal failure in sepsis. Kidney Int Suppl 1998;66:S34.
13. Yasuda H, Yuen PS, Hu X, et al. Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int 2006;69:1535.
14. Leelahavanichkul A, Yasuda H, Doi K, et al. Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice. Am J Physiol Renal Physiol 2008;295:F1825.
15. Miyaji T, Hu X, Yuen PS, et al. Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice. Kidney Int 2003;64:1620.
16. Yasuda H, Leelahavanichkul A, Tsunoda S, et al. Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol 2008;294:F1050.
17. Cohen J, Carlet J. INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996;24:1431.
18. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699.
19. Gupta A, Berg DT, Gerlitz B, et al. Role of protein C in renal dysfunction after polymicrobial sepsis. J Am Soc Nephrol 2007;18:860.
20. Heidecke CD, Hensler T, Weighardt H, et al. Selective defects of T lymphocyte function in patients with lethal intraabdominal infection. Am J Surg 1999;178:288.
21. Kasama T, Miwa Y, Isozaki T, et al. Neutrophil-derived cytokines: Potential therapeutic targets in inflammation. Curr Drug Targets Inflamm Allergy 2005;4:273.
22. Schmidt C, Hocherl K, Schweda F, et al. Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis. Crit Care Med 2007;35:2110.
23. Schmidt C, Hocherl K, Schweda F, et al. Regulation of renal sodium transporters during severe inflammation. J Am Soc Nephrol 2007;18:1072.
24. Schmidt C, Hocherl K, Bucher M. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol 2007;292:F1479.
25. Schmidt C, Hocherl K, Bucher M. Regulation of renal glucose transporters during severe inflammation. Am J Physiol Renal Physiol 2007;292:F804.
26. De Vriese AS. Prevention and treatment of acute renal failure in sepsis. J Am Soc Nephrol 2003;14:792.