TNF-α-dependent loss of IKKβ-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 16, 2011, Pages 6567-6572

  Mankan, Arun K ^a   Canli, Ozge ^a   Schwitalla, Sarah ^a   Ziegler, Paul ^a   Tschopp, Jurg ^b   Korn, Thomas ^a   Greten, Florian R ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

CD34; IKK inhibitor; IL 7R

Indexed keywords

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; I KAPPA B BETA; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CELL SURVIVAL; CONTROLLED STUDY; GRANULOCYTOSIS; INNATE IMMUNITY; MOUSE; MYELOID DENDRITIC CELL; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; STEM CELL; TH17 CELL;

ANIMALS; APOPTOSIS; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; ENCEPHALITIS; I-KAPPA B KINASE; IMMUNITY, INNATE; INTERLEUKIN-17; INTERLEUKIN-1BETA; MICE; MICE, KNOCKOUT; MYELOID PROGENITOR CELLS; MYELOPOIESIS; NF-KAPPA B; SIGNAL TRANSDUCTION; TH17 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; MUS;

EID: 79955572318     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1018331108     Document Type: Article

References (29)

1. Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27:693-733.
2. Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
3. Karin M, Greten FR (2005) NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5:749-759. (Pubitemid 41400849)
4. Bollrath J, Greten FR (2009) IKK/NF-kappaB and STAT3 pathways: Central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep 10: 1314-1319.
5. Baud V, Karin M (2009) Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8:33-40.
6. Nagashima K, et al. (2006) Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta. Blood 107:4266-4273. (Pubitemid 43801350)
7. Li ZW, Omori SA, Labuda T, Karin M, Rickert RC (2003) IKK beta is required for peripheral B cell survival and proliferation. J Immunol 170:4630-4637. (Pubitemid 36519969)
8. Senftleben U, Li ZW, Baud V, Karin M (2001) IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. Immunity 14:217-230. (Pubitemid 32289287)
9. Greten FR, et al. (2007) NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130:918-931. (Pubitemid 47332565)
10. Nakai S, Aihara K, Hirai Y (1989) Interleukin-1 potentiates granulopoiesis and thrombopoiesis by producing hematopoietic factors in vivo. Life Sci 45:585-591. (Pubitemid 19198544)
11. Akashi K, Traver D, Miyamoto T, Weissman IL (2000) A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404:193-197. (Pubitemid 30154488)
12. Clausen BE, Burkhardt C, Reith W, Renkawitz R, Förster I (1999) Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res 8: 265-277. (Pubitemid 29523965)
13. Schroder K, Tschopp J (2010) The inflammasomes. Cell 140:821-832.
14. Demetri GD, Griffin JD (1991) Granulocyte colony-stimulating factor and its receptor. Blood 78:2791-2808.
15. Forlow SB, et al. (2001) Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. Blood 98:3309-3314.
16. Rieger MA, Hoppe PS, Smejkal BM, Eitelhuber AC, Schroeder T (2009) Hematopoietic cytokines can instruct lineage choice. Science 325:217-218.
17. Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27:485-517.
18. Chung Y, et al. (2009) Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30:576-587.
19. Nathan C (2006) Neutrophils and immunity: Challenges and opportunities. Nat Rev Immunol 6:173-182.
20. Smith E, et al. (2009) T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo. J Immunol 183:5685-5693.
21. Sutton CE, et al. (2009) Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341.
22. Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27:519-550.
23. Miossec P, Korn T, Kuchroo VK (2009) Interleukin-17 and type 17 helper T cells. N Engl J Med 361:888-898.
24. Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-kappa B system: A treasure trove for drug development. Nat Rev Drug Discov 3:17-26. (Pubitemid 38088695)
25. Kleinschek MA, et al. (2007) IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med 204:161-170. (Pubitemid 46148766)
26. van Loo G, et al. (2006) Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol 7: 954-961. (Pubitemid 44263909)
27. Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL (2003) Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278:1910-1914. (Pubitemid 36801431)
28. Sutton C, Brereton C, Keogh B, Mills KH, Lavelle EC (2006) A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203:1685-1691. (Pubitemid 44036274)
29. Gulen MF, et al. (2010) The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32:54-66.