Anti-diabetic effects of Allium cepa (onions) aqueous extracts on alloxan-induced diabetic Rattus novergicus

Journal of Medicinal Plants Research

Volumn 5, Issue 7, 2011, Pages 1134-1139

  Ozougwu, Jevas C ^a  

^a UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Allium cepa; Alloxan diabetic rats; Hypoglycaemia; Hypolipidaemia

Indexed keywords

ALLOXAN; CHOLESTEROL; GLIBENCLAMIDE; GLUCOSE; LIPID; ONION EXTRACT; SODIUM CHLORIDE; WATER;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE INCREASE; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HYPERGLYCEMIA; HYPERLIPIDEMIA; LIPID BLOOD LEVEL; NONHUMAN; ONION; RAT;

ALLIUM CEPA; RATTUS;

EID: 79955558636     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Akah P, Njoku O, Nwanguma A, Akunyili D (2004). Effects of aqueous leaf extracts of Vernonia amygdolina on blood glucose and triglyceride levels of alloxan-induced diabetic rats. Anim. Res. Int., 1(2): 90-94.
2. Akhtar FM, Ali MR (1984). Study of the antidiabetic effect of a compound medicinal plant prescription in normal and diabetic rabbit. J. Pak. Med. Assoc., 34: 239-244.
3. ADA (2005). Total prevalence of diabetes and pre-diabetes.15 pp. American Diabetes Association, (http://www.diabetes.org/diabetesstatistics/prevalence.jsp). Retrieved on 07/06/2007.
4. Andallu B, Suryakantham V, lakshmi SB (2001). Effect of mulberry (Morms indica L) therapy on plasma and erythrocyte membrane lipids in patients with Type 2 diabetes. Clin. Chem. Acta, 314: 47-53.
5. Babu PS, Srivivasan K (1997). Influence of dietary capsaicin and Allium cepa on the metabolic abnormalities associated with streptozocin induced diabetes mellitus. Mole. Cell. Biochem., 125: 49-57.
6. Battu GR, Mamidipalli, SN, Parimi R, Viriyala RK, Patchula RP, Mood LR (2007). Hypoglycaemic and antihyperglycemic effect of alcoholic extract of Benincasa hispida in normal and in alloxan induced diabetic rats. Pharmacogn. Mag, 3: 101-105.
7. Bell BM, Hayes JR, Stout RW (1984). Lipoprotein, insulin and glycaemic control in diabetes. Hormonal Metab. Res., 16: 252-260.
8. Betteridge DJ (1994). Diabetic dyslipidaemia, Am. J. Med., 96: 25-31.
9. Blumenthal M (1998). The complete German commission E monographs: Therapeutic guide to herbal medicines. Am. Botanical Assoc., Austin, USA.
10. Boyle JP, Honeycutt AA, Narayam KM, Hoerger TJ, Geiss LS, Chens H, Thompson TJ (2001). Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the United State. Diabet. Care, 24: 1936-1940.
11. Cho SK, Park JY, Park EM, Choi MS, Lee MY, Jeon SM, Jang MK, Kim MJ, Park YB (2002). Alteration of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extracts. Clinical Chem. Acta, 317: 109-117.
12. Erasto P, Adebola PO, Grierson DS, Afolayan AJ (2005). An ethanobotanical study of plants used for the treatment of diabetes in the Eastern Cape Province, South Africa. Afr. J. Biotechnol., 4(2): 1458-1460.
13. Gbile ZO (1980). Vernacular Names of Nigerian Plants (Yoruba). Forestry Res. Institute Nig., Ibadan.
14. Genstat for Windows Discovery Edition 2 (2007). Lawes Agricultural Trust, Rothamsted, United Kingdom.
15. Habib MY, Islam MS, Awal MA, Khan MA (2005). Herbal products: A novel approach for diabetic patients. Pak. J. Nutr., 4(1): 17-21.
16. Hamme HR, Martins S, Federlin K, Geisen K, Brownee M (1991). Aminoguanidine treatment inhibits the development of experimental diabetes retinopathy. Proc. Natl. Acad Sci., 88: 11555-11558.
17. th edition). McGraw Hill Company limited, U.S.A.
18. Ikram MA (1971). A review on chemical and medicinal aspects Of Allium cepa. Pak. J. Sci. Ind. Res., 14(5): 395-398.
19. Jain RC (1976). Onion and garlic in experimental cholesterol induced atherosclerosis in rabbit I. Indian J. Med. Res., 64(10): 1509-1515.
20. King H, Aubert RE, Herman WH (1998). Global burden of diabetes 1995-2005: Prevalence, numerical estimates and projections. Diabetes Care, 21: 1414-1431.
21. Kumari K, Mathew BC, Augusti KT (1995). Anti-diabetic and hypolipidaemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn. Indian J. Biochem. Biophys., 32: 49-54.
22. Laakso M (1996). Lipids and lipoproteins as risk factors for coronary heart disease in non insulin dependent diabetes mellitus. Ann. Med., 28: 341-345.
23. Massing MW, Sueta CA, Chowdhury M, Biggs DP, Simpson RJ (2001). Lipid management among coronary artery disease patients in diabetes mellitus or advanced age. Am. J. Cardiol., 87: 646-664.
24. Mathew PT, Augusti KT (1975). Hypoglycaemic effects of onion, Allium cepa linn on diabetes mellitus. A preliminary report. Indian J. Physiol. Pharmacol., 19(4): 212-217.
25. Nafisa PC, Chakradnar VL, Vandana SP, Suresh RN (2007). An experimental evaluation of the antidiabetic and antilipidaemic properties of a standardized Momordica charantia fruit extract. BMC Complementary Altern. Med., 7: 29-55.
26. Orchard TJ (1990). Dyslipoproteinemia and diabetes: Endocrinol. Metab. Clin. North Am., 19: 361-379.
27. Osinubi AA, Ajayi OG, Adesiyun AE (2006). Evaluation of the antidiabetic effect of aqueous leaf extracts of Tripinanthus butungil in male spragne Dawley rats. Med. J. Islamic World Academy of Sci., 16(1): 41-47.
28. Pushparaj P, Tan CH, Tan BK (2000). Effect of Averrhoa bilimli leaf extract on blood glucose and lipids in streptozotocin diabetic rats. J. Ethnopharmacol., 72: 69-76.
29. Sharma SR, Dwivedi SK, Swarup D (1996). Hypoglycaemic and hypolipidaemic effects of Cinnamon tomala nees leaves. Indian J. Exp. Biol., 34: 372-374.
30. Sharma SS, Kochupilla IV, Gupta SK (1997). Antiemetic efficacy of ginger (Zingiber officinale) against cisplatin-induced emesis in Dogs. J. Ethnopharmacol., 57: 93-96.
31. Sharpe PC, Yue KM, Catterwood MA, Mcmarter D, Tribble ER (1998). The effects of glucose induced oxidative stress on growth and extracellular matrix gene expression of vascular smooth muscle cells. Diabetologia, 41: 1210-1219.
32. th edition, Jaypee Brothers Medical publishers Limited, New Delhi, India.
33. Steiner G (1999). Risk factors for macrovascular disease in Type 2 diabetes. Classic lipid abnormalities. Diabetes Care, 22(3): 6-9.
34. Tukuncu NB, Bcyraktar M, Varli K (1998). Reversal of defective nerve conductions with vitamin E supplementation in type 2 diabetes. Diabetes Care, 21: 1915-1918.
35. WHO (1999). Definition, diagnosis and classification of diabetes mellitus and its complications. World Health Organization Department of Nonncomunicable Disease Surveillance. (http://whglibdoc.who.int/hg/1999/WHO-NCD-NCS-99.2pdf). 60 p. Retrieved on 7/6/2007.
36. WHO (1980). The World Health organization Committee on diabetes mellitus: Second Report. Technical Report Series 646. World Health Organization, Geneva.
37. Zarrow MX, Yochim JM, McCarthy JL (1964). Experimental Endocrinology, A Source Book of Basic Techniques. Academic Press. New York.