Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis

Veterinary Research

Volumn 42, Issue 1, 2011, Pages

  Le Maréchal, Caroline ^a,b   Jardin, Julien ^a   Jan, Gwenal ^a   Even, Sergine ^a   Pulido, Coralie ^b   Guibert, Jean Michel ^b   Hernandez, David ^c   François, Patrice ^c   Schrenzel, Jacques ^c   Demon, Dieter ^d   Meyer, Evelyne ^d   Berkova, Nadia ^a   Thiéry, Richard ^b   Vautor, Eric ^b,e   Le Loir, Yves ^a  

^a UMR1253   (France)

^b FRENCH AGENCY FOR FOOD   (France)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^d GHENT UNIVERSITY   (Belgium)

^e LVD06 ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

BOVIDAE; MUS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEIN; PROTEOME;

ANIMAL; ANIMAL DISEASE; ARTICLE; FEMALE; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; MASTITIS; METABOLISM; MICROBIOLOGY; MOUSE; SEROLOGY; SHEEP; SHEEP DISEASE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; TANDEM MASS SPECTROMETRY; TWO DIMENSIONAL GEL ELECTROPHORESIS; UDDER;

ANIMALS; BACTERIAL PROTEINS; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; MAMMARY GLANDS, ANIMAL; MASTITIS; MICE; PROTEOME; SEROLOGIC TESTS; SHEEP; SHEEP DISEASES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TANDEM MASS SPECTROMETRY;

EID: 79955547536     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1186/1297-9716-42-35     Document Type: Article

References (112)

1. Stochastic bio-economic model of bovine intramammary infection. Halasa T, Nielen M, Huirne RBM, Hogeveen H, Livest Sci 2009 124 295 305 10.1016/j.livsci.2009.02.019
2. How do mastites impact technological properties of milk and quality of milk products? Le Maréchal C, Thiéry R, Vautor E, Le Loir Y, Dairy Sci Technol 2011
3. Identification of vaccine candidate antigens of Staphylococcus aureus by serological proteome analysis. Vytvytska O, Nagy E, Bluggel M, Meyer HE, Kurzbauer R, Huber LA, Klade CS, Proteomics 2002 2 580 590 10.1002/1615- 9861(200205)2:5<580::AID-PROT580>3.0.CO;2-G 11987132 (Pubitemid 34507348)
4. Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection. Burlak C, Hammer CH, Robinson MA, Whitney AR, McGavin MJ, Kreiswirth BN, DeLeo FR, Cell Microbiol 2007 9 1172 1190 10.1111/j.1462-5822.2006.00858.x 17217429 (Pubitemid 46547137)
5. High throughput sequencing and proteomics to identify immunogenic proteins of a new pathogen: the dirty genome approach. Greub G, Kebbi-Beghdadi C, Bertelli C, Collyn F, Riederer BM, Yersin C, Croxatto A, Raoult D, PLoS One 2009 4 8423 10.1371/journal.pone.0008423 20037647
6. Genotyping of Staphylococcus aureus isolated from various sites on farms with dairy sheep using pulsed-field gel electrophoresis. Vautor E, Abadie G, Guibert JM, Huard C, Pepin M, Vet Microbiol 2003 96 69 79 10.1016/S0378-1135(03) 00207-4 14516709 (Pubitemid 37153403)
7. Genetic differences among Staphylococcus aureus isolates from dairy ruminant species: a single-dye DNA microarray approach. Vautor E, Magnone V, Rios G, Le BK, Bergonier D, Lina G, Meugnier H, Barbry P, Thiery R, Pepin M, Vet Microbiol 2009 133 105 114 10.1016/j.vetmic.2008.06.006 18640795 (Pubitemid 50213058)
8. Genome-Wide Analysis of Ruminant Staphylococcus aureus Reveals Diversification of the Core Genome. Ben Zakour NL, Sturdevant DE, Even S, Guinane CM, Barbey C, Alves PD, Cochet MF, Gautier M, Otto M, Fitzgerald JR, Le Loir Y, J Bacteriol 2008 190 6302 6317 10.1128/JB.01984-07 18567666
9. Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation. Guinane CM, Ben Zakour NL, Tormo-Mas MA, Weinert LA, Lowder BV, Cartwright RA, Smyth DS, Smyth CJ, Lindsay J, Gould KA, Witney A, Hinds J, Bollback JP, Rambaut A, Penadés JR, Fitzgerald JR, Genome Biol Evol 2010 2 454 466 10.1093/gbe/evq031 20624747
10. Difference in virulence between Staphylococcus aureus isolates causing gangrenous mastitis versus subclinical mastitis in a dairy sheep flock. Vautor E, Cockfield J, Le Maréchal C, Le Loir Y, Chevalier M, Robinson DA, Thiery R, Lindsay J, Vet Res 2009 40 56 67 10.1051/vetres/2009039 19576164
11. Development of serological proteome analysis of mastitis by Staphylococcus aureus in ewes. Le Maréchal C, Jan G, Even S, McCulloch JA, Azevedo V, Thiéry R, Vautor E, Le Loir Y, J Microbiol Methods 2009 79 131 136 19735677
12. Influence of iron depletion on growth kinetics, siderophore production, and protein expression of Staphylococcus aureus. Trivier D, Davril M, Houdret N, Courcol RJ, FEMS Microbiol Lett 1995 127 195 199 10.1111/j.1574-6968.1995. tb07473.x 7758933
13. De novo bacterial genome sequencing: millions of very short reads assembled on a desktop computer. Hernandez D, Francois P, Farinelli L, Osteras M, Schrenzel J, Genome Res 2008 18 802 809 10.1101/gr.072033.107 18332092 (Pubitemid 351645070)
14. Changes in protein synthesis during thermal adaptation of Propionibacterium freudenreichii subsp. shermanii. Anastasiou R, Leverrier P, Krestas I, Rouault A, Kalantzopoulos G, Boyaval P, Tsakalidou E, Jan G, Int J Food Microbiol 2006 108 301 314 16473425
15. Improvement and simplification of low-background silver staining of proteins by using sodium dithionite. Rabilloud T, Carpentier G, Tarroux P, Electrophoresis 1988 9 288 291 10.1002/elps.1150090608 2466660
16. Predictability by somatic cell counts related to prevalence of intrammary infection within herds. McDermott MP, Erb HN, Natzke RP, J Dairy Sci 1982 65 1535 1539 10.3168/jds.S0022-0302(82)82378-3 7142531
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Laemmli UK, Nature 1970 227 680 685 10.1038/227680a0 5432063
18. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Towbin H, Staehelin T, Gordon J, Proc Natl Acad Sci USA 1979 76 4350 4354 10.1073/pnas.76.9.4350 388439 (Pubitemid 9256559)
19. Nanoelectrospray tandem mass spectrometry and sequence similarity searching for identification of proteins from organisms with unknown genomes. Shevchenko A, Sunyaev S, Liska A, Bork P, Shevchenko A, Methods Mol Biol 2003 211 221 234 12489434
20. UniProtKB database. http://www.uniprot.org/help/uniprotkb
21. Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Ishihama Y, Oda Y, Tabata T, Sato T, Nagasu T, Rappsilber J, Mann M, Mol Cell Proteomics 2005 4 1265 1272 10.1074/mcp.M500061-MCP200 15958392 (Pubitemid 41448714)
22. A toolbox for validation of mass spectrometry peptides identification and generation of database: IRMa. Dupierris V, Masselon C, Court M, Kieffer-Jaquinod S, Bruley C, Bioinformatics 2009 25 1980 1981 10.1093/bioinformatics/btp301 19420053
23. Prediction of surface exposed proteins in Streptococcus pyogenes, with a potential application to other Gram-positive bacteria. Barinov A, Loux V, Hammani A, Nicolas P, Langella P, Ehrlich D, Maguin E, van de GM, Proteomics 2009 9 61 73 10.1002/pmic.200800195 19053137
24. Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B. Yamaguchi T, Nishifuji K, Sasaki M, Fudaba Y, Aepfelbacher M, Takata T, Ohara M, Komatsuzawa H, Amagai M, Sugai M, Infect Immun 2002 70 5835 5845 10.1128/IAI.70.10.5835-5845.2002 12228315
25. Activation of the SspA serine protease zymogen of Staphylococcus aureus proceeds through unique variations of a trypsinogen-like mechanism and is dependent on both autocatalytic and metalloprotease-specific processing. Nickerson NN, Prasad L, Jacob L, Delbaere LT, McGavin MJ, J Biol Chem 2007 282 34129 34138 10.1074/jbc.M705672200 17878159 (Pubitemid 350159450)
26. Severity of E. coli mastitis is mainly determined by cow factors. Burvenich C, Van MV, Mehrzad J, ez-Fraile A, Duchateau L, Vet Res 2003 34 521 564 10.1051/vetres:2003023 14556694 (Pubitemid 37419855)
27. Virulence genes of bovine Staphylococcus aureus from persistent and nonpersistent intramammary infections with different clinical characteristics. Haveri M, Roslof A, Rantala L, Pyorala S, J Appl Microbiol 2007 103 993 1000 10.1111/j.1365-2672.2007.03356.x 17897203 (Pubitemid 47493256)
28. Influence of Staphylococcus aureus strain on mammary quarter milk production. Middleton JR, Fox LK, Vet Rec 2002 150 411 413 10.1136/vr.150.13.411 11999279 (Pubitemid 34296322)
29. Les mammites dues Staphylococcus aureus. Rainard P, Gilbert FB, Staphylococcus aureus Paris: Tec&Doc, Le Loir Y, Gautier M, 2010 211 232
30. Virulence factors involved in the pathogenesis of bovine intramammary infections due to Staphylococcus aureus. Sutra L, Poutrel B, J Med Microbiol 1994 40 79 89 10.1099/00222615-40-2-79 8107066 (Pubitemid 24071727)
31. Inflammatory mediators in Escherichia coli-induced mastitis in mice. Notebaert S, Demon D, Vanden BT, Vandenabeele P, Meyer E, Comp Immunol Microbiol Infect Dis 2008 31 551 565 10.1016/j.cimid.2007.10.004 18243314
32. Susceptibility of mice to invasive aspergillosis correlates with delayed cell influx into the lungs. Svirshchevskaya EV, Shevchenko MA, Huet D, Femenia F, Latge JP, Boireau P, Berkova NP, Int J Immunogenet 2009 36 289 299 10.1111/j.1744-313X.2009.00869.x 19744035
33. Differential abilities of capsulated and noncapsulated Staphylococcus aureus isolates from diverse agr groups to invade mammary epithelial cells. Buzzola FR, Alvarez LP, Tuchscherr LP, Barbagelata MS, Lattar SM, Calvinho L, Sordelli DO, Infect Immun 2007 75 886 891 10.1128/IAI.01215-06 17145949 (Pubitemid 46203453)
34. The cytokine markers in Staphylococcus aureus mastitis of bovine mammary gland. Alluwaimi AM, Leutenegger CM, Farver TB, Rossitto PV, Smith WL, Cullor JS, J Vet Med B Infect Dis Vet Public Health 2003 50 105 111 12667186 (Pubitemid 36429631)
35. The cytokines of bovine mammary gland: prospects for diagnosis and therapy. Alluwaimi AM, Res Vet Sci 2004 77 211 222 10.1016/j.rvsc.2004.04.006 15276772 (Pubitemid 39023385)
36. Characterization of cytokine expression in milk somatic cells during intramammary infections with Escherichia coli or Staphylococcus aureus by real-time PCR. Lee JW, Bannerman DD, Paape MJ, Huang MK, Zhao X, Vet Res 2006 37 219 229 10.1051/vetres:2005051 16472521
37. The capacity of bovine endothelial cells to eliminate intracellular Staphylococcus aureus and Staphylococcus epidermidis is increased by the proinflammatory cytokines TNF-alpha and IL-1beta. Oviedo-Boyso J, Cardoso-Correa BI, Cajero-Juarez M, Bravo-Patino A, Valdez-Alarcon JJ, Baizabal-Aguirre VM, FEMS Immunol Med Microbiol 2008 54 53 59 10.1111/j.1574-695X.2008.00447.x 18625014
38. Staphylococcus aureus leucotoxin LukM/F' is secreted and stimulates neutralising antibody response in the course of intramammary infection. Rainard P, Vet Res 2007 38 685 696 10.1051/vetres:2007026 17583665 (Pubitemid 350043444)
39. Serological proteome analysis of Staphylococcus aureus isolated from sub-clinical mastitis. Tedeschi G, Taverna F, Negri A, Piccinini R, Nonnis S, Ronchi S, Zecconi A, Vet Microbiol 2009 134 388 391 10.1016/j.vetmic.2008.08.019 18835110
40. Molecular correlates of host specialization in Staphylococcus aureus. Herron-Olson L, Fitzgerald JR, Musser JM, Kapur V, PLoS One 2007 2 1120 10.1371/journal.pone.0001120 17971880 (Pubitemid 351586837)
41. Proteomics of Staphylococcus aureus - current state and future challenges. Hecker M, Engelmann S, Cordwell SJ, J Chromatogr B Analyt Technol Biomed Life Sci 2003 787 179 195 10.1016/S1570-0232(02)00907-8 12659740 (Pubitemid 36351273)
42. Proteomic analysis of exoproteins expressed by enterotoxigenic Staphylococcus aureus strains. Pocsfalvi G, Cacace G, Cuccurullo M, Serluca G, Sorrentino A, Schlosser G, Blaiotta G, Malorni A, Proteomics 2008 8 2462 2476 10.1002/pmic.200700965 18563740
43. Comparative proteome analysis of Staphylococcus aureus biofilm and planktonic cells and correlation with transcriptome profiling. Resch A, Leicht S, Saric M, Pasztor L, Jakob A, Gotz F, Nordheim A, Proteomics 2006 6 1867 1877 10.1002/pmic.200500531 16470655
44. Mapping the pathways to staphylococcal pathogenesis by comparative secretomics. Sibbald MJ, Ziebandt AK, Engelmann S, Hecker M, de JA, Harmsen HJ, Raangs GC, Stokroos I, Arends JP, Dubois JY, van Dijl JM, Microbiol Mol Biol Rev 2006 70 755 788 10.1128/MMBR.00008-06 16959968 (Pubitemid 44484692)
45. Extracellular proteins of Staphylococcus aureus and the role of SarA and sigma B. Ziebandt AK, Weber H, Rudolph J, Schmid R, Hoper D, Engelmann S, Hecker M, Proteomics 2001 1 480 493 10.1002/1615-9861(200104)1:4<480::AID- PROT480>3.0.CO;2-O 11681202 (Pubitemid 33588302)
46. Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation. Ziebandt AK, Kusch H, Degner M, Jaglitz S, Sibbald MJ, Arends JP, Chlebowicz MA, Albrecht D, Pantucek R, Doskar J, Ziebuhr W, Bröker BM, Hecker M, van Dijl JM, Engelmann S, Proteomics 2010 10 1634 1644 10.1002/pmic.200900313 20186749
47. Proteomic profiling of cell envelope-associated proteins from Staphylococcus aureus. Gatlin CL, Pieper R, Huang ST, Mongodin E, Gebregeorgis E, Parmar PP, Clark DJ, Alami H, Papazisi L, Fleischmann RD, Gill SR, Peterson SN, Proteomics 2006 6 1530 1549 10.1002/pmic.200500253 16470658
48. Relative quantitative comparisons of the extracellular protein profiles of Staphylococcus aureus UAMS-1 and its sarA, agr, and sarAagr regulatory mutants using one-dimensional polyacrylamide gel electrophoresis and nanocapillary liquid chromatography coupled with tandem mass spectrometry. Jones RC, Deck J, Edmondson RD, Hart ME, J Bacteriol 2008 190 5265 5278 10.1128/JB.00383-08 18539737
49. Housekeeping enzymes as virulence factors for pathogens. Pancholi V, Chhatwal GS, Int J Med Microbiol 2003 293 391 401 10.1078/1438-4221-00283 14760970 (Pubitemid 38082345)
50. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. Antikainen J, Kuparinen V, Lahteenmaki K, Korhonen TK, FEMS Immunol Med Microbiol 2007 51 526 534 10.1111/j.1574-695X.2007.00330.x 17892475 (Pubitemid 350076163)
51. Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. Lee EY, Choi DY, Kim DK, Kim JW, Park JO, Kim S, Kim SH, Desiderio DM, Kim YK, Kim KP, Gho YS, Proteomics 2009 9 5425 5436 10.1002/pmic.200900338 19834908
52. Proteomics-Based Identification of Anchorless Cell Wall Proteins as Vaccine Candidates against Staphylococcus aureus. Glowalla E, Tosetti B, Kronke M, Krut O, Infect Immun 2009 77 2719 2729 10.1128/IAI.00617-08 19364833
53. Vaccine assembly from surface proteins of Staphylococcus aureus. Stranger-Jones YK, Bae T, Schneewind O, Proc Natl Acad Sci USA 2006 103 16942 16947 10.1073/pnas.0606863103 17075065 (Pubitemid 44737357)
54. A novel Staphylococcus aureus vaccine: Iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S-aureus sepsis model. Kuklin NA, Clark DJ, Secore S, Cook J, Cope LD, McNeely T, Noble L, Brown MJ, Zorman JK, Wang XM, Pancari G, Fan H, Isett K, Burgess B, Bryan J, Brownlow M, George H, Meinz M, Liddell ME, Kelly R, Schultz L, Montgomery D, Onishi J, Losada M, Martin M, Ebert T, Tan CY, Schofield TL, Nagy E, Meineke A, et al. Infect Immun 2006 74 2215 2223 10.1128/IAI.74.4.2215- 2223.2006 16552052
55. Immune responses to a Staphylococcus aureus GapC/B chimera and its potential use as a component of a vaccine for S. aureus mastitis. Perez-Casal J, Prysliak T, Kerro-Dego O, Potter AA, Vet Immunol Immunopathol 2006 109 85 97 10.1016/j.vetimm.2005.07.024 16165220 (Pubitemid 41739679)
56. Anti-alpha-hemolysin monoclonal antibodies mediate protection against Staphylococcus aureus pneumonia. Ragle BE, Bubeck WJ, Infect Immun 2009 77 2712 2718 10.1128/IAI.00115-09 19380475
57. Human Immune Proteome in Experimental Colonization with Staphylococcus aureus. Holtfreter S, Thi THN, Wertheim H, Steil L, Kusch H, Quoc PT, Engelmann S, Hecker M, Volker U, van Belkum A, Bröker BM, Clin Vaccine Immunol 2009 16 1607 1614 10.1128/CVI.00263-09 19759252
58. Staphylococcus aureus leucotoxin LukM/F' is secreted and stimulates neutralising antibody response in the course of intramammary infection. Rainard P, Vet Res 2007 38 685 696 10.1051/vetres:2007026 17583665 (Pubitemid 350043444)
59. Immune evasion by Staphylococcus aureus conferred by iron-regulated surface determinant protein IsdH. Visai L, Yanagisawa N, Josefsson E, Tarkowski A, Pezzali I, Rooijakkers SH, Foster TJ, Speziale P, Microbiology 2009 155 667 679 10.1099/mic.0.025684-0 19246738
60. Transcriptional regulation of the Staphylococcus aureus thioredoxin and thioredoxin reductase genes in response to oxygen and disulfide stress. Uziel O, Borovok I, Schreiber R, Cohen G, Aharonowitz Y, J Bacteriol 2004 186 326 334 10.1128/JB.186.2.326-334.2004 14702300 (Pubitemid 38076421)
61. The Staphylococcus aureus Protein Sbi Acts as a Complement Inhibitor and Forms a Tripartite Complex with Host Complement Factor H and C3b. Haupt K, Reuter M, van den Elsen J, Burman J, Halbich S, Richter J, Skerka C, Zipfel PF, Plos Pathog 2008 4 1000250 10.1371/journal.ppat.1000250 19112495
62. Identification of a novel maturation mechanism and restricted substrate specificity for the SspB cysteine protease of Staphylococcus aureus. Massimi I, Park E, Rice K, Muller-Esterl W, Sauder D, McGavin MJ, J Biol Chem 2002 277 41770 41777 10.1074/jbc.M207162200 12207024 (Pubitemid 35257486)
63. Coordinated and differential control of aureolysin (aur) and serine protease (sspA) transcription in Staphylococcus aureus by sarA, rot and agr (RNAIII). Oscarsson J, Tegmark-Wisell K, Arvidson S, Int J Med Microbiol 2006 296 365 380 10.1016/j.ijmm.2006.02.019 16782403 (Pubitemid 44354300)
64. A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages. Kubica M, Guzik K, Koziel J, Zarebski M, Richter W, Gajkowska B, Golda A, iag-Gudowska A, Brix K, Shaw L, Foster T, Potempa J, PLoS One 2008 3 1409 10.1371/journal.pone.0001409 18183290 (Pubitemid 351234509)
65. The human fibrinolytic system is a target for the staphylococcal metalloprotease aureolysin. Beaufort N, Wojciechowski P, Sommerhoff CP, Szmyd G, Dubin G, Eick S, Kellermann J, Schmitt M, Potempa J, Magdolen V, Biochem J 2008 410 157 165 10.1042/BJ20070650 17973626 (Pubitemid 351300335)
66. Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin. Kulig P, Zabel BA, Dubin G, Alllen SJ, Ohyama T, Potempa J, Handel TM, Butcher EC, Cichy J, J Immunol 2007 178 3713 3720 17339469 (Pubitemid 46417639)
67. A New Pathway of Staphylococcal Pathogenesis: Apoptosis-Like Death Induced by Staphopain B in Human Neutrophils and Monocytes. Smagur J, Guzik K, Magiera L, Bzowska M, Gruca M, Thogersen IB, Enghild JJ, Potempa J, J Innate Immun 2009 1 98 108 10.1159/000181014 20375568
68. The role and regulation of the extracellular proteases of Staphylococcus aureus. Shaw L, Golonka E, Potempa J, Foster SJ, Microbiology 2004 150 217 228 10.1099/mic.0.26634-0 14702415 (Pubitemid 38111488)
69. Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments. Coulter SN, Schwan WR, Ng EY, Langhorne MH, Ritchie HD, Westbrock-Wadman S, Hufnagle WO, Folger KR, Bayer AS, Stover CK, Mol Microbiol 1998 30 393 404 10.1046/j.1365-2958.1998.01075.x 9791183 (Pubitemid 28480189)
70. Effects of oligopeptide permease in group a streptococcal infection. Wang CH, Lin CY, Luo YH, Tsai PJ, Lin YS, Lin MT, Chuang WJ, Liu CC, Wu JJ, Infect Immun 2005 73 2881 2890 10.1128/IAI.73.5.2881-2890.2005 15845494 (Pubitemid 40570357)
71. Relevance of peptide uptake systems to the physiology and virulence of Streptococcus agalactiae. Samen U, Gottschalk B, Eikmanns BJ, Reinscheid DJ, J Bacteriol 2004 186 1398 1408 10.1128/JB.186.5.1398-1408.2004 14973032 (Pubitemid 38248730)
72. OppA of Listeria monocytogenes, an oligopeptide-binding protein required for bacterial growth at low temperature and involved in intracellular survival. Borezee E, Pellegrini E, Berche P, Infect Immun 2000 68 7069 7077 10.1128/IAI.68.12.7069-7077.2000 11083832 (Pubitemid 32463421)
73. Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin. Kroh HK, Panizzi P, Bock PE, Proc Natl Acad Sci USA 2009 106 7786 7791 10.1073/pnas.0811750106 19416890
74. On the Prothrombin Content in Milk. Schonheyder F, Thomsen SB, Acta Physiol Scand 1942 4 309 316 10.1111/j.1748-1716.1942.tb01464.x
75. Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. Clarke SR, Brummell KJ, Horsburgh MJ, McDowell PW, Mohamad SA, Stapleton MR, Acevedo J, Read RC, Day NP, Peacock SJ, Mond JJ, Kokai-Kun JF, Foster SJ, J Infect Dis 2006 193 1098 1108 10.1086/501471 16544250
76. Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus. Etz H, Minh DB, Henics T, Dryla A, Winkler B, Triska C, Boyd AP, Sollner J, Schmidt W, von Ahsen U, Buschle M, Gill SR, Kolonay J, Khalak H, Fraser CM, von Gabain A, Nagy E, Meinke A, Proc Natl Acad Sci USA 2002 99 6573 6578 10.1073/pnas.092569199 11997460 (Pubitemid 34526174)
77. Human antibody response during sepsis against targets expressed by methicillin resistant Staphylococcus aureus. Lorenz U, Ohlsen K, Karch H, Hecker M, Thiede A, Hacker J, FEMS Immunol Med Microbiol 2000 29 145 153 10.1111/j.1574-695X.2000.tb01517.x 11024354
78. Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus. Stapleton MR, Horsburgh MJ, Hayhurst EJ, Wright L, Jonsson IM, Tarkowski A, Kokai-Kun JF, Mond JJ, Foster SJ, J Bacteriol 2007 189 7316 7325 10.1128/JB.00734-07 17675373 (Pubitemid 47557346)
79. Cloning and sequence analysis of genes encoding Staphylococcus hyicus exfoliative toxin types A, B, C, and D. Ahrens P, Andresen LO, J Bacteriol 2004 186 1833 1837 10.1128/JB.186.6.1833-1837.2004 14996814 (Pubitemid 38314528)
80. Distribution of the exfoliative toxin D gene in clinical Staphylococcus aureus isolates in France. Yamasaki O, Tristan A, Yamaguchi T, Sugai M, Lina G, Bes M, Vandenesch F, Etienne J, Clin Microbiol Infect 2006 12 585 588 10.1111/j.1469-0691.2006.01410.x 16700711 (Pubitemid 43740773)
81. Mastitis of dairy small ruminants. Bergonier D, de CR, Rupp R, Lagriffoul G, Berthelot X, Vet Res 2003 34 689 716 10.1051/vetres:2003030 14556701 (Pubitemid 37407277)
82. Identification of immunogenic cell wall-associated proteins of Streptococcus suis serotype 2. Zhang A, Xie C, Chen H, Jin M, Proteomics 2008 8 3506 3515 10.1002/pmic.200800007 18686301
83. Identification of immunodominant antigens from Helicobacter pylori and evaluation of their reactivities with sera from patients with different gastroduodenal pathologies. Kimmel B, Bosserhoff A, Frank R, Gross R, Goebel W, Beier D, Infect Immun 2000 68 915 920 10.1128/IAI.68.2.915-920.2000 10639463 (Pubitemid 30056553)
84. Towards the immunoproteome of Neisseria meningitidis. Mendum TA, Newcombe J, McNeilly CL, McFadden J, PLoS One 2009 4 5940 10.1371/journal.pone.0005940 19529772
85. Identification of in vivo-expressed immunogenic proteins by serological proteome analysis of the Bacillus anthracis secretome. Chitlaru T, Gat O, Grosfeld H, Inbar I, Gozlan Y, Shafferman A, Infect Immun 2007 75 2841 2852 10.1128/IAI.02029-06 17353282 (Pubitemid 46870165)
86. Identification of immunogenic and serum binding proteins of Staphylococcus epidermidis. Sellman BR, Howell AP, Kelly-Boyd C, Baker SM, Infect Immun 2005 73 6591 6600 10.1128/IAI.73.10.6591-6600.2005 16177335 (Pubitemid 41368825)
87. Proteomic profiling of serologic response to Candida albicans during host-commensal and host-pathogen interactions. Pitarch A, Nombela C, Gil C, Methods Mol Biol 2009 470 369 411 full-text 19089396
88. Evaluation of recombinant fructose-1,6-bisphosphate aldolase ELISA test for the diagnosis of Schistosoma japonicum in water buffaloes. Peng SY, Lee KM, Tsaihong JC, Cheng PC, Fan PC, Res Vet Sci 2008 85 527 533 10.1016/j.rvsc.2008. 02.005 18371996
89. Identification and characterization of novel immunogenic proteins of Streptococcus suis serotype 2. Geng H, Zhu L, Yuan Y, Zhang W, Li W, Wang J, Zheng Y, Wei K, Cao W, Wang H, Jiang Y, J Proteome Res 2008 7 4132 4142 10.1021/pr800196v 18630869
90. Identification of protein candidates for the serodiagnosis of Q fever endocarditis by an immunoproteomic approach. Sekeyova Z, Kowalczewska M, Decloquement P, Pelletier N, Spitalska E, Raoult D, Eur J Clin Microbiol Infect Dis 2009 28 287 295 10.1007/s10096-008-0621-4 18797945
91. DNA vaccination by electroporation and boosting with recombinant proteins enhances the efficacy of DNA vaccines for Schistosomiasis japonica. Dai Y, Zhu Y, Harn DA, Wang X, Tang J, Zhao S, Lu F, Guan X, Clin Vaccine Immunol 2009 16 1796 1803 10.1128/CVI.00231-09 19812258
92. DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Da'dara AA, Li YS, Xiong T, Zhou J, Williams GM, McManus DP, Feng Z, Yu XL, Gray DJ, Harn DA, Vaccine 2008 26 3617 3625 18524429
93. Identification of Staphylococcus aureus proteins recognized by the antibody-mediated immune response to a biofilm infection. Brady RA, Leid JG, Camper AK, Costerton JW, Shirtliff ME, Infect Immun 2006 74 3415 3426 10.1128/IAI.00392-06 16714572 (Pubitemid 43794532)
94. Identification of major immunogenic proteins of Mycoplasma synoviae isolates. Bercic RL, Slavec B, Lavric M, Narat M, Bidovec A, Dovc P, Bencina D, Vet Microbiol 2008 127 147 154 10.1016/j.vetmic.2007.07.020 17720337 (Pubitemid 350267031)
95. Protection against pneumococcal infection by a ribosomal preparation. Thompson HC, Snyder IS, Infect Immun 1971 3 16 23 16557934
96. A study of the antigenicity of Rickettsia helvetica proteins using two-dimensional gel electrophoresis. Hajem N, Weintraub A, Nimtz M, Romling U, Pahlson C, APMIS 2009 117 253 262 10.1111/j.1600-0463.2009.02435.x 19338513
97. Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection. John M, Kudva IT, Griffin RW, Dodson AW, McManus B, Krastins B, Sarracino D, Progulske-Fox A, Hillman JD, Handfield M, Tarr PI, Calderwood SB, Infect Immun 2005 73 2665 2679 10.1128/IAI.73.5.2665-2679.2005 15845468 (Pubitemid 40570331)
98. Generation and characterization of monoclonal antibodies against Staphylococcus aureus thermonuclease. Brakstad OG, Maeland JA, APMIS 1989 97 166 174 10.1111/j.1699-0463.1989.tb00772.x 2920104 (Pubitemid 19068729)
99. Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia. Havlasova J, Hernychova L, Brychta M, Hubalek M, Lenco J, Larsson P, Lundqvist M, Forsman M, Krocova Z, Stulik J, Macela A, Proteomics 2005 5 2090 2103 10.1002/pmic.200401123 15892173 (Pubitemid 40770573)
100. Vaccination and passive immunisation against Staphylococcus aureus. Schaffer AC, Lee JC, Int J Antimicrob Agents 2008 32 Suppl 1 71 S78 10.1016/j.ijantimicag.2008.06.009 18757184
101. Induction of Staphylococcus aureus-specific IgA and agglutination potency in milk of cows by mucosal immunization. Tempelmans Plat-Sinnige MJ, Verkaik NJ, van Wamel WJ, de GN, Acton DS, van BA, Vaccine 2009 27 4001 4009 10.1016/j.vaccine.2009.04.034 19389449
102. Heterogeneity of the humoral immune response following Staphylococcus aureus bacteremia. Verkaik NJ, Boelens HA, de Vogel CP, Tavakol M, Bode LG, Verbrugh HA, van BA, van Wamel WJ, Eur J Clin Microbiol Infect Dis 2010 29 509 518 10.1007/s10096-010-0888-0 20186449
103. Staphylococcus aureus immunodominant surface antigen B is a cell-surface associated nucleic acid binding protein. Mackey-Lawrence NM, Potter DE, Cerca N, Jefferson KK, BMC Microbiol 2009 9 61 10.1186/1471-2180-9-61 19323837
104. Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureus. Heinrichs JH, Gatlin LE, Kunsch C, Choi GH, Hanson MS, J Bacteriol 1999 181 1436 1443 10049373 (Pubitemid 29110801)
105. Evaluation of some Staphylococcus aureus iron-regulated proteins as vaccine targets. Ster C, Beaudoin F, Diarra MS, Jacques M, Malouin F, Lacasse P, Vet Immunol Immunopathol 2010 136 311 318 10.1016/j.vetimm.2010.03.010 20416953
106. Immune responses to specific antigens of Streptococcus pneumoniae and Moraxella catarrhalis in the respiratory tract. Samukawa T, Yamanaka N, Hollingshead S, Klingman K, Faden H, Infect Immun 2000 68 1569 1573 10.1128/IAI.68.3.1569-1573.2000 10678976 (Pubitemid 30108560)
107. Antibody response to alpha- and betahemolysin from Staphylococcus aureus in patients with staphylococcal infections and in normals. Christensson B, Hedstrom SA, Kronvall G, Acta Pathol Microbiol Immunol Scand B 1983 91 351 356 6659935 (Pubitemid 14238645)
108. Towards the immune proteome of Staphylococcus aureus-The anti-S. aureus antibody response. Holtfreter S, Kolata J, Broker BM, Int J Med Microbiol 2010 300 176 192 10.1016/j.ijmm.2009.10.002 19889576
109. Immunogenicity of toxins during Staphylococcus aureus infection. Verkaik NJ, Dauwalder O, Antri K, Boubekri I, de Vogel CP, Badiou C, Bes M, Vandenesch F, Tazir M, Hooijkaas H, Verbrugh HA, van Belkum A, Etienne J, Lina G, Ramdani-Bouguessa N, van Wamel WJ, Clin Infect Dis 2010 50 61 68 10.1086/648673 19947854
110. Leucotoxic activities of Staphylococcus aureus strains isolated from cows, ewes, and goats with mastitis: importance of LukM/LukF'-PV leukotoxin. Rainard P, Corrales JC, Barrio MB, Cochard T, Poutrel B, Clin Diagn Lab Immunol 2003 10 272 277 12626454 (Pubitemid 36314452)
111. Functional selection of vaccine candidate peptides from Staphylococcus aureus whole-genome expression libraries in vitro. Weichhart T, Horky M, Sollner J, Gangl S, Henics T, Nagy E, Meinke A, von GA, Fraser CM, Gill SR, Hafner M, von Ahsen U, Infect Immun 2003 71 4633 4641 10.1128/IAI.71.8.4633-4641.2003 12874343 (Pubitemid 36919930)
112. Comparison of antibody repertoires against Staphylococcus aureus in healthy individuals and in acutely infected patients. Dryla A, Prustomersky S, Gelbmann D, Hanner M, Bettinger E, Kocsis B, Kustos T, Henics T, Meinke A, Nagy E, Clin Diagn Lab Immunol 2005 12 387 398 15753252 (Pubitemid 41175334)