Different effects of mirtazapine and venlafaxine on brain activation: An open randomized controlled fMRI study

Journal of Clinical Psychiatry

Volumn 72, Issue 4, 2011, Pages 448-457

  Frodl, Thomas ^a,b,c   Scheuerecker, Johanna ^a   Schoepf, Veronika ^a   Linn, Jennifer ^a   Koutsouleris, Nikolaos ^a   Bokde, Arun L W ^b   Hampel, Harald ^a,b   Möller, Hans Jürgen ^a   Brückmann, Hartmut ^a   Wiesmann, Martin ^a   Meisenzahl, Eva ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

MIRTAZAPINE; VENLAFAXINE;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BASAL GANGLION; CEREBELLUM; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EMOTION; FACE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUSIFORM GYRUS; HIPPOCAMPUS; HUMAN; MAJOR DEPRESSION; MALE; OXYGEN BLOOD LEVEL; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SENSORIMOTOR CORTEX; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; SUPPLEMENTARY MOTOR AREA; THALAMUS; TREATMENT RESPONSE;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BASAL GANGLIA; BRAIN; CYCLOHEXANOLS; DEPRESSIVE DISORDER, MAJOR; EMOTIONS; FEMALE; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIANSERIN; PREFRONTAL CORTEX; PSYCHIATRIC STATUS RATING SCALES; TIME FACTORS;

EID: 79955486451     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.09m05393blu     Document Type: Article

References (40)

1. Murray CJ, Lopez AD. Evidence-based health policy - lessons from the Global Burden of Disease Study. Science. 1996;274(5288):740-743. (Pubitemid 26398244)
2. Stahl S. Stahl's Essential Psychopharmacology. New York, NY: Cambridge University Press; 2008.
3. Sheline YI, Barch DM, Donnelly JM, et al. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry. 2001;50(9):651-658. (Pubitemid 33043767)
4. Davidson RJ, Irwin W, Anderle MJ, et al. The neural substrates of affective processing in depressed patients treated with venlafaxine. Am J Psychiatry. 2003;160(1):64-75. (Pubitemid 36042428)
5. Fu CH, Williams SC, Cleare AJ, et al. Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry. 2004;61(9):877-889. (Pubitemid 39181077)
6. Haddjeri N, Blier P, de Montigny C. Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain. J Pharmacol Exp Ther. 1996;277(2):861-871.
7. De Boer T, Nefkens F, Van Helvoirt A. The alpha 2-adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo. Eur J Pharmacol. 1994;253(1-2):R5-R6.
8. de Boer T. The pharmacologic profile of mirtazapine. J Clin Psychiatry. 1996;57(suppl 4):19-25. (Pubitemid 26177340)
9. Devoto P, Flore G, Pira L, et al. Mirtazapine-induced corelease of dopa-mine and noradrenaline from noradrenergic neurons in the medial prefrontal and occipital cortex. Eur J Pharmacol. 2004;487(1-3):105-111. (Pubitemid 38368986)
10. Smith DF, Hansen SB, Jakobsen S, et al. Neuroimaging of mirtazapine enantiomers in humans. Psychopharmacology (Berl). 2008;200(2): 273-279.
11. 11C] DASB positron emission tomography study. Am J Psychiatry. 2004;161(5): 826-835. (Pubitemid 38625335)
12. First M, Spitzer R, Gibbon M. Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II). Washington, DC: American Psychiatric Press; 1997.
13. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23(1):56-62.
14. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9(1):97-113.
15. Gur RC, Schroeder L, Turner T, et al. Brain activation during facial emotion processing. Neuroimage. 2002;16(3, pt 1):651-662. (Pubitemid 34852429)
16. Hariri AR, Mattay VS, Tessitore A, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science. 2002; 297(5580):400-403. (Pubitemid 34790769)
17. Friston KJ HA, Worsley KJ, Polina J-P, et al. Statistical parametric maps in functional imaging: a general linear approach Hum Brain Map 1994; 2:189-210.
18. Schwartz S, Ponz A, Poryazova R, et al. Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy. Erain. 2008;131(pt 2):514-522. (Pubitemid 351197605)
19. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002; 15(1):273-289. (Pubitemid 34852226)
20. Muneoka K, Shirayama Y, Takigawa M, et al. Brain region-specific effects of short-term treatment with duloxetine, venlafaxine, milnacipran and sertraline on monoamine metabolism in rats. Neurochem Res. 2009;34(3): 542-555.
21. Chen CH, Suckling J, Ooi C, et al. Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology. 2008;33(8):1909-1918. (Pubitemid 351832606)
22. Arce E, Simmons AN, Lovero KL, et al. Escitalopram effects on insula and amygdala BOLD activation during emotional processing. Psychopharmacology (Eerl). 2008;196(4):661-672.
23. Völlm B, Richardson P, McKie S, et al. Serotonergic modulation of neuronal responses to behavioural inhibition and reinforcing stimuli: an fMRI study in healthy volunteers. Eur J Neurosci. 2006;23(2):552-560.
24. Mayberg HS. Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci. 1997;9(3):471-481. (Pubitemid 27363950)
25. Paus T. Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Rev Neurosci. 2001;2(6):417-424. (Pubitemid 33674798)
26. Zilles K, Amunts K. Receptor mapping: architecture of the human cerebral cortex. Curr Opin Neurol. 2009;22(4):331-339.
27. Palomero-Gallagher N, Vogt BA, Schleicher A, et al. Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. Hum Erain Mapp. 2009;30(8):2336-2355.
28. Callado LF, Meana JJ, Grijalba B, et al. Selective increase of alpha2A- adrenoceptor agonist binding sites in brains of depressed suicide victims. J Neurochem. 1998;70(3):1114-1123. (Pubitemid 28113645)
29. Flugge G, van Kampen M, Meyer H, et al. Alpha2A and alpha2C- adrenoceptor regulation in the brain: alpha2A changes persist after chronic stress. Eur J Neurosci. 2003;17(5):917-928. (Pubitemid 36411589)
30. Scheuerecker J, Frodl T, Koutsouleris N, et al. Cerebral differences in explicit and implicit emotional processing - an fMRI study. Neuropsychobiology. 2007;56(1):32-39. (Pubitemid 350158725)
31. Sommer M, Koch MA, Paulus W, et al. Disconnection of speech-relevant brain areas in persistent developmental stuttering. Lancet. 2002;360(9330):380- 383.
32. Bruijn JA, Moleman P, Mulder PG, et al. Depressed in-patients respond differently to imipramine and mirtazapine. Pharmacopsychiatry. 1999;32(3):87-92. (Pubitemid 29364441)
33. Kanwisher N, McDermott J, Chun MM. The fusiform face area: a module in human extrastriate cortex specialized for face perception. J Neurosci. 1997;17(11):4302-4311. (Pubitemid 27220621)
34. Siegle GJ, Carter CS, Thase ME. Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy. Am J Psychiatry. 2006;163(4):735-738. (Pubitemid 44464587)
35. Wu J, Buchsbaum MS, Gillin JC, et al. Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex. Am J Psychiatry. 1999;156(8):1149-1158. (Pubitemid 29374872)
36. Frodl T, Scheuerecker J, Albrecht J, et al. Neuronal correlates of emotional processing in patients with major depression. World J Biol Psychiatry. 2009;10(3):202-208.
37. Anand A, Li Y, Wang Y, et al. Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry. 2005;57(10):1079-1088. (Pubitemid 40615768)
38. Surguladze S, Brammer MJ, Keedwell P, et al. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol Psychiatry. 2005;57(3):201-209. (Pubitemid 40187363)
39. Gotlib IH, Krasnoperova E, Yue DN, et al. Attentional biases for negative interpersonal stimuli in clinical depression. J Abnorm Psychol. 2004; 113(1):121-135.
40. McGrath PJ, Stewart JW, Fava M, et al. Tranylcypromine versus venla-faxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report. Am J Psychiatry. 2006;163(9): 1531-1541, quiz 1666. (Pubitemid 44465752)