Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F] fluoroanilino)quinazolines, potential EGFR imaging probes

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 9, 2011, Pages 2959-2965

  Vasdev, Neil ^a   Dorff, Peter N ^a   O'Neil, James P ^a   Chin, Frederick T ^a   Hanrahan, Stephen ^a   Vanbrocklin, Henry F ^a,b  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

EGFR; Fluorine 18; Fluoroaniline; Hepatocytes; Metabolism; PET; Quinazoline

Indexed keywords

2 FLUOROANILINOQUINAZOLINE DRIVATIVE F 18; 4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 FLUOROANILINOQUINAZOLINE DRIVATIVE F 18; 6,7 DIALKOXY 4 (2 , 3 AND 4 FLUOROANILINO)QUINAZOLINE DERIVATIVE F 18; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROANILINE DERIVATIVE F 18; FLUOROANILINOQUINAZOLINE DRIVATIVE F 18; FLUORONITROBENZENE DERIVATIVE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; DEFLUORINATION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG POTENCY; DRUG PURIFICATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FLOW RATE; HUMAN; HUMAN CELL; IC 50; LIVER CELL; MOLECULAR IMAGING; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; RADIOCHEMISTRY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPECIES DIFFERENCE; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; FEMALE; FLUORINE RADIOISOTOPES; HEPATOCYTES; HUMANS; MICE; QUINAZOLINES; RADIOPHARMACEUTICALS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

MUS;

EID: 79955482527     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.032     Document Type: Article

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