Real-time monitoring of spatial and temporal metabolic changes during focal cerebral ischemia in rats

Brain Research

Volumn 1389, Issue , 2011, Pages 125-132

  Livnat, Amir ^a   Barbiro Michaely, Efrat ^a   Mayevsky, Avraham ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

Cerebral blood flow; Focal ischemia; Metabolic challenge; Middle cerebral artery occlusion; Mitochondrial dysfunction; Short anoxia

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; FOCAL BRAIN ISCHEMIA; IN VIVO STUDY; MALE; MICROCIRCULATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRION; MULTI SITE MULTI PARAMETRIC MONITORING SYSTEM; NEUROMONITORING; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; REPERFUSION;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; HEMODYNAMICS; MALE; NAD; RATS; RATS, WISTAR;

RATTUS;

EID: 79955477668     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2011.03.008     Document Type: Article

References (24)

1. N.J. Alkayed, I. Harukuni, A.S. Kimes, E.D. London, R.J. Traystman, P.D. Hurn, and P.A. Grady Gender-linked brain injury in experimental stroke editorial comment Stroke 29 1998 159 166 (Pubitemid 28046959)
2. P. Bolognese, J.I. Miller, I.M. Heger, and T.H. Milhorat Laser-Doppler flowmetry in neurosurgery J. Neurosurg. Anesthesiol. 5 1993 151 158 (Pubitemid 23207467)
3. R. Brouns, and P.P. De Deyn The complexity of neurobiological processes in acute ischemic stroke Clin. Neurol. Neurosurg. 111 2009 483 495
4. L. Canevari, S. Kuroda, T.E. Bates, J.B. Clark, and B.K. Siesjo Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat J. Cereb. Blood Flow Metab. 17 1997 1166 1169 (Pubitemid 27514741)
5. J. Folbergrova, Q. Zhao, K. Katsura, and B.K. Siesjo N-tert-butyl-alpha- phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia Proc. Natl Acad. Sci. USA 92 1995 5057 5061
6. M.D. Ginsberg Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis Lecture Stroke 34 2003 214 223 (Pubitemid 36070826)
7. K.A. Hossmann Pathophysiological basis of translational stroke research Folia Neuropathol. 47 2009 213 227
8. T. Kristian, and B.K. Siesjo Calcium in ischemic cell death Stroke 29 1998 705 718 (Pubitemid 28145802)
9. P. Lipton Ischemic cell death in brain neurons Physiol. Rev. 79 1999 1431 1568 (Pubitemid 29473320)
10. A. Livnat, E. Barbiro-Michaely, and A. Mayevsky Mitochondrial function and cerebral blood flow responses under unilateral carotid occlusion in rats Proc. SPIE 7180 2009 3 10
11. A. Livnat, M. Tolmasov, E. Barbiro-Michaely, and A. Mayevsky Real-time monitoring of mitochondrial function and cerebral blood flow following focal ischemia in rats JIOHS 1 2008 63 69
12. E.Z. Longa, P.R. Weinstein, S. Carlson, and R. Cummins Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91 (Pubitemid 19040218)
13. A. Mayevsky Brain energy metabolism of the conscious rat exposed to various physiological and pathological situations Brain Res. 113 1976 327 338
14. A. Mayevsky Brain NADH redox state monitored in vivo by fiber optic surface fluorometry Brain Res. 319 1984 49 68 (Pubitemid 14126013)
15. A. Mayevsky, and B. Chance Oxidation-reduction states of NADH in vivo: from animals to clinical use Mitochondrion 7 2007 330 339 (Pubitemid 47300172)
16. A. Mayevsky, S. Meilin, T. Manor, E. Ornstein, N. Zarchin, and J. Sonn Multiparametric monitoring of brain oxygen balance under experimental and clinical conditions Neurol. Res. 20 1998 S76 S80
17. A. Mayevsky, and G. Rogatsky Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies Am. J. Physiol. Cell Physiol. 292 2007 C615 C640
18. A. Mayevsky, and I. Ziv Oscillations of cortical oxidative metabolism and microcirculation in the ischaemic brain Neurol. Res. 13 1991 39 47
19. S. Meilin, N. Zarchin, and A. Mayevsky Inter-relation between hemodynamic, metabolic, ionic and electrical activities during ischemia and reperfusion in the gerbil brain Neurol. Res. 21 1999 699 704 (Pubitemid 29510844)
20. T.H. Murphy, and D. Corbett Plasticity during stroke recovery: from synapse to behaviour Nat. Rev. Neurosci. 10 2009 861 872
21. R. Schmid-Elsaesser, S. Zausinger, E. Hungerhuber, A. Baethmann, H.J. Reulen, and J.H. Garcia A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-doppler flowmetry Stroke 29 1998 2162 2170 (Pubitemid 28443535)
22. B.K. Siesjo Pathophysiology and treatment of focal cerebral ischemia Part I: Pathophysiol. J. Neurosurg. 77 1992 169 184
23. N.R. Sims, and H. Muyderman Mitochondria, oxidative metabolism and cell death in stroke Biochim. Biophys. Acta (BBA) Mol. Basis Dis. 1802 2010 80 91
24. C. Zhan, and J. Yang Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats Pharmacol. Res. 53 2006 303 309 (Pubitemid 43247544)