Triamcinolone acetonide-mediated oxidative injury in retinal cell culture: Comparison with dexamethasone

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 12, 2007, Pages 5742-5749

  Chung, Hyewon ^a   Hwang, Jung Jin ^a   Koh, Jae Young ^a   Kim, June Gone ^a   Yoon, Young Hee ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CASPASE 3; DEXAMETHASONE SODIUM PHOSPHATE; DNA; FLUORESCEIN DIACETATE; FLUORESCENT DYE; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE P38; PROPIDIUM IODIDE; STRESS ACTIVATED PROTEIN KINASE; TRIAMCINOLONE ACETONIDE; CASP3 PROTEIN, RAT; DEXAMETHASONE; GLUCOCORTICOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DEATH; CELL STRUCTURE; CELL SURVIVAL; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DRUG CYTOTOXICITY; DRUG EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; RETINA CELL; RETINA INJURY; ANIMAL; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NEWBORN; RETINA; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; CASPASE 1; CASPASE 3; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DEXAMETHASONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUCOCORTICOIDS; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICROSCOPY, FLUORESCENCE; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RETINA; TRIAMCINOLONE ACETONIDE;

EID: 38549152306     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.07-0566     Document Type: Article

References (17)

1. Massin P, Audren F, Haouchine B, et al. Intravitreal triamcinolone acetonide for diabetic diffuse macular edema: preliminary results of a prospective controlled trial. Ophthalmology. 2004;111:218-224.
2. Jonas JB, Kreissig I, Sofker A, Degenring RF. Intravitreal injection of triamcinolone for diffuse diabetic macular edema. Arch Ophthalmol. 2003;121:57-61.
3. Park CH, Jaffe GJ, Fekrat S. Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. Am J Ophthalmol. 2003;136:419-425.
4. Jonas JB, Hayler JK, Panda-Jonas S. Intravitreal injection of crystalline cortisone as adjunctive treatment of proliferative vitreoretinopathy. Br J Ophthalmol. 2000;84:1064-1067.
5. Jonas JB, Akkoyun I, Budde WM, Kreissig I, Degenring RF. Intravitreal reinjection of triamcinolone for exudative age-related macular degeneration. Arch Ophthalmol. 2004;122:218-222.
6. Inoue M, Takeda K, Morita K, Yamada M, Tanigawara Y, Oguchi Y. Vitreous concentrations of triamcinolone acetonide in human eyes after intravitreal or subtenon injection. Am J Ophthalmol. 2004;138:1046-1048.
7. Mason JO 3rd, Somaiya MD, Singh RJ. Intravitreal concentration and clearance of triamcinolone acetonide in nonvitrectomized human eyes. Retina. 2004;24:900-904.
8. Yeung CK, Chan KP, Chan CK, Pang CP, Lam DS. Cytotoxicity of triamcinolone on cultured human retinal pigment epithelial cells: comparison with dexamethasone and hydrocortisone. Jpn J Ophthalmol. 2004;48:236-242.
9. Narayanan R, Mungcal JK, Kenney MC, Seigel GM, Kuppermann BD. Toxicity of triamcinolone acetonide on retinal neurosensory and pigment epithelial cells. Invest Ophthalmol Vis Sci. 2006;47:722-728.
10. Yoon YH, Jeong KH, Shim MJ, Koh JY. High vulnerability of GABA-immunoreactive neurons to kainate in rat retinal cultures: correlation with the kainate-stimulated cobalt uptake. Brain Res. 1999;27:823:33-41.
11. Yeung CK, Chan KP, Chiang SW, Pang CP, Lam DS. The toxic and stress responses of cultured human retinal pigment epithelium (ARPE19) and human glial cells (SVG) in the presence of triamcinolone. Invest Ophthalmol Vis Sci. 2003;44:5293-5300.
12. Szurman P, Kaczmarek R, Spitzer MS, et al. Differential toxic effect of dissolved triamcinolone and its crystalline deposits on cultured human retinal pigment epithelium (ARPE19) cells. Exp Eye Res. 2006;83:584-592.
13. Loh KP, Huang SH, De Silva R, Tan BK, Zhu YZ. Oxidative stress: apoptosis in neuronal injury. Curr Alzheimer Res. 2006;3:327-337.
14. Mehta SL, Manhas N, Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev. 2007;54:34-66.
15. Wang X, Martindale JL, Liu Y, Holbrook NJ. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J. 1998;15:291-300.
16. Stoica BA, Movsesyan VA, Knoblach SM, Faden AI. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol Cell Neurosci. 2005;29:355-371.
17. Suzuma I, Murakami T, Suzuma K, et al. Cyclic stretch-induced reactive oxygen species generation enhances apoptosis in retinal pericytes through c-jun NH2-terminal kinase activation. Hypertension. 2007;49:347-354.