Effect of radiolabeled metabolite elimination from the brain on the accuracy of cerebral enzyme activity estimation using positron emission tomography with substrate tracers

NeuroImage

Volumn 56, Issue 3, 2011, Pages 1105-1110

  Ohya, Tomoyuki ^a   Okamura, Toshimitsu ^a   Nagai, Yuji ^a   Fukushi, Kiyoshi ^a   Irie, Toshiaki ^a   Suhara, Tetsuya ^a   Zhang, Ming Rong ^a   Fukumura, Toshimitsu ^a   Kikuchi, Tatsuya ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Brain; Enzyme; Metabolite elimination; Positron emission tomography; Tracer kinetics; Tracer sensitivity

Indexed keywords

ACETYLCHOLINESTERASE; N FLUOROETHYLPIPERIDIN 4 YLMETHYLACETATE F 18; N METHYLPIPERIDIN 4 YLACETATE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BRAIN LEVEL; BRAIN REGION; CONTROLLED STUDY; DRUG ELIMINATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME SUBSTRATE; HAPLORHINI; ISOTOPE LABELING; MALE; METABOLITE; MOLECULAR IMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; QUANTITATIVE STUDY;

ACETATES; ACETYLCHOLINESTERASE; ALGORITHMS; ANIMALS; BRAIN; COMPUTER SIMULATION; FLUORINE RADIOISOTOPES; LEAST-SQUARES ANALYSIS; MACACA MULATTA; MALE; MONTE CARLO METHOD; NONLINEAR DYNAMICS; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 79955467749     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2011.02.030     Document Type: Article

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