N-[18F]fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity

Journal of Medicinal Chemistry

Volumn 48, Issue 7, 2005, Pages 2577-2583

  Kikuchi, Tatsuya ^a,c   Zhang, Ming Rong ^a,b   Ikota, Nobuo ^a   Fukushi, Kiyoshi ^a   Okamura, Toshimitsu ^a,c   Suzuki, Kazutoshi ^a   Arano, Yasushi ^c   Irie, Toshiaki ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b 141 0032   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE DERIVATIVE; ACETYLCHOLINESTERASE; FLUORINE 18; N ETHYLPIPERIDIN 3 YL ACETATE C 14; N ETHYLPIPERIDIN 3 YL PROPIONATE C 14; N ETHYLPIPERIDIN 4 YL ACETATE C 14; N ETHYLPIPERIDIN 4 YL PROPIONATE C 14; N FLUOROETHYLPIPERIDIN 4 YLMETHYL ACETATE F 18; N METHYLPIPERIDIN 4 YL ACETATE C 11; N METHYLPIPERIDIN 4 YL PROPIONATE C 11; OCTANOL; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; WATER; ACETIC ACID DERIVATIVE; ACETYLCHOLINE; CHOLINESTERASE INHIBITOR; DRUG DERIVATIVE; FLUORINE; N FLUOROETHYLPIPERIDIN 4 YLMETHYL ACETATE; N-FLUOROETHYLPIPERIDIN-4-YLMETHYL ACETATE; RADIOPHARMACEUTICAL AGENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN HOMOGENATE; BRAIN MAPPING; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DEMENTIA; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; IN VITRO STUDY; IN VIVO STUDY; LEWY BODY; LIPOPHILICITY; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; RAT; ANIMAL; ARTIFICIAL MEMBRANE; BRAIN; CHEMISTRY; ENZYMOLOGY; HUMAN; HYDROLYSIS; METABOLISM; PERMEABILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TISSUE DISTRIBUTION; WISTAR RAT;

ACETATES; ACETYLCHOLINE; ACETYLCHOLINESTERASE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHOLINESTERASE INHIBITORS; FLUORINE RADIOISOTOPES; HUMANS; HYDROLYSIS; MALE; MEMBRANES, ARTIFICIAL; PERMEABILITY; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 17144377857     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049100w     Document Type: Article

References (19)

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