Influence of topical dexamethasone applications on insulin, glucose, thyroid hormone and cortisol levels in dogs

Research in Veterinary Science

Volumn 90, Issue 3, 2011, Pages 491-497

  Gottschalk, J ^a   Einspanier, A ^a   Ungemach, F R ^a   Abraham, G ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Cortisol; Dogs; Hypothalamic pituitary adrenal (HPA) axis; Hypothalamic pituitary thyroid (HPT) axis; Insulin; Thyroid hormones; Topical glucocorticoids

Indexed keywords

DEXAMETHASONE ACETATE; EAR DROPS; GLUCOSE; HYDROCORTISONE; INSULIN; LIOTHYRONINE; PLACEBO; THYROID HORMONE; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG DOSAGE FORM COMPARISON; DRUG WITHDRAWAL; EVENING DOSAGE; FEMALE; GLUCOSE BLOOD LEVEL; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHYROIDISM; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIOTHYRONINE BLOOD LEVEL; LOTION; MALE; MORNING DOSAGE; NONHUMAN; THYROID HORMONE BLOOD LEVEL; THYROID HORMONE RELEASE; THYROXINE BLOOD LEVEL;

ADMINISTRATION, TOPICAL; ANIMALS; BLOOD GLUCOSE; DEXAMETHASONE; DOGS; GLUCOCORTICOIDS; HYDROCORTISONE; INSULIN; MALE; THYROID HORMONES;

CANIS FAMILIARIS;

EID: 79955462900     PISSN: 00345288     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rvsc.2010.06.026     Document Type: Article

References (46)

1. Abraham G., Gottschalk J., Ungemach F.R. Evidence for ototopical glucocorticoid-induced decrease in hypothalamic-pituitary-adrenal axis response and liver function. Endocrinology 2005, 146:3163-3171.
2. Andrew R.C., Walker B.R. Glucocorticoids and insulin resistance: old hormones, new targets. Clinical Science 1999, 96:513-523.
3. Benker G., Raida M., Olbricht T., Wagner R., Reinhardt W., Reinwein D. TSH secretion in Cushing's syndrome: relation to glucocorticoid excess, diabetes, goiter, and the 'sick euthyroid syndrome'. Clinical Endocrinology 1990, 33:777-786.
4. Brabant A., Brabant G., Schuermeyer T., Ranft U., Schmidt F.W., Hesch R.D., von zur Muhlen A. The role of glucocorticoids in the regulation of thyrotropin. Acta Endocrinologica (Copenhagen) 1989, 121:95-100.
5. Carnes M., Barksdale C.M., Kalin N.H., Brownfield M.S., Lent S.J. Effects of dexamethasone on central and peripheral ACTH systems in the rat. Neuroendocrinology 1987, 45:160-164.
6. Clark D.J., Lipworth B.J. Evaluation of corticotropin releasing factor stimulation and basal markers of hypothalamic-pituitary-adrenal axis suppression in asthmatic patients. Chest 1997, 112:1248-1252.
7. Chopra I.J., Williams D.E., Orgiazzi J., Solomon D.H. Opposite effects of dexamethasone on serum concentrations of 3,3',5'-triiodothyronine (reverse T3) and 3,3'5-triiodothyronine (T3). The Journal of Clinical Endocrinology and Metabolism 1975, 41:911-920.
8. Dallman M.F., Akana S.F., Levin N., Walker C.D., Bradbury M.J., Suemaru S., Scribner K.S. Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis. Annals of the New York Academy of Science 1994, 746:22-31.
9. Darras V.M., Hume R., Visser T.J. Regulation of thyroid hormone metabolism during fetal development. Molecular and Cellular Endocrinology 1999, 151:37-47.
10. De Feo P., Perriello G., Torlone E., Ventura M.M., Fanelli C., Santeusanio F., Brunetti P., Gerich J.E., Bolli G.B. Contribution of cortisol to glucose counter-regulation in humans. American Journal of Physiology 1989, 257:E35-42.
11. Delaunay F., Khan A., Cintra A., Davani B., Ling Z.C., Andersson A., Ostenson C.G., Gustafsson J., Efendic S., Okret S. Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. The Journal of Clinical Investigation 1997, 100:2094-2098.
12. Dinneen S., Alzaid A., Miles J., Rizza R. Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans. The Journal of Clinical Investigation 1993, 92:2283-2290.
13. Exton J.H., Harper S.C., Tucker A.L., Ho R.J. Effects of insulin on gluconeogenesis and cyclic AMP levels in perfused livers from diabetic rats. Biochimica et Biophysica Acta 1973, 329:23-40.
14. Feldmann R.J., Maibach H.I. Regional variation in percutaneous penetration of 14C cortisol in man. The Journal of Investigative Dermatology 1967, 48:181-183.
15. Fisher D.A. Adverse effects of topical corticosteroid use. The Western Journal of Medicine 1995, 162:123-126.
16. Gamstedt A., Jarnerot G., Kagedal B. Dose related effects of betamethasone on iodothyronines and thyroid hormone-binding proteins in serum. Acta Endocrinologica 1981, 96:484-490.
17. Hedeskov C.J. Mechanism of glucose-induced insulin secretion. Physiological Reviews 1980, 60:442-509.
18. Khan A., Ostenson C.G., Berggren P.O., Efendic S. Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice. American Journal Physiology 1992, 263:E663-666.
19. Keller-Wood M.E., Dallman M.F. Corticosteroid inhibition of ACTH secretion. Endocrine Reviews 1984, 5:1-24.
20. Lambillotte C., Gilon P., Henquin J.C. Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. The Journal of Clinical Investigation 1997, 99:414-423.
21. Lecocq F.R., Mebane D., Madison L.L. The acute effect of hydrocortisone on hepatic glucose output and peripheral glucose utilization. The Journal of Clinical Investigation 1964, 43:237-246.
22. Levin C., Maibach H.I. Topical corticosteroid-induced adrenocortical insufficiency: clinical implications. American Journal of Clinical Dermatology 2002, 3:141-147.
23. Ling Z.C., Khan A., Delauny F., Davani B., Ostenson C.G., Gustafsson J.A., Okret S., Landau B.R., Efendic S. Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release. Diabetologia 1998, 41:634-639.
24. Lipworth B.J. Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis. Archives of Internal Medicine 1999, 59:941-955.
25. Malerbi D., Liberman B., Giurno-Filho A., Giannella-Neto D., Wajchenberg B.L. Glucocorticoids and glucose metabolism: hepatic glucose production in untreated addisonian patients and on two different levels of glucocorticoid administration. Clinical Endocrinology 1988, 28:415-422.
26. McMahon M., Gerich J., Rizza R. Effects of glucocorticoids on carbohydrate metabolism. Diabetes/Metabolism Reviews 1988, 4:17-30.
27. Meij B.P., Mol J.A., Bevers M.M., Rijnberk A. Alterations in anterior pituitary function of dogs with pituitary-dependent hyperadrenocorticism. Journal of Endocrinology 1997, 154:505-512.
28. Meissner H.P. Electrical characteristics of the beta-cells in pancreatic islets. Journal of Physiology 1976, 72:757-767.
29. Mills P.C., Cross S.E. Regional differences in the in vitro penetration of hydrocortisone through equine skin. Journal of Veterinary Pharmacology and Therapeutics 2006, 29:25-30.
30. Nicod N., Giusti V., Besse C., Tappy L. Metabolic adaptations to dexamethasone-induced insulin resistance in healthy volunteers. Obesity Research 2003, 11:625-631.
31. Nicoloff J.T., Fisher D.A., Appleman M.D. The role of glucocorticoids in the regulation of thyroid function in man. The Journal of Clinical Investigation 1970, 49:1922-1929.
32. Nosadini R., Del Prato S., Tiengo A., Valerio A., Muggeo M., Opocher G., Mantero F., Duner E., Marescotti C., Mollo F. Insulin resistance in Cushing's syndrome. The Journal of Clinical Endocrinology and Metabolism 1983, 57:529-536.
33. O'Brien T.D., Westermark P., Johnson K.H. Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated, and dexamethasone-treated rats. Diabetes 1991, 40:1701-1706.
34. Ogawa A., Johnson J.H., Ohneda M., McAllister C.T., Inman L., Alam T., Unger R.H. Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. The Journal of Clinical Investigation 1992, 90:497-504.
35. Ormerod A.D., How J., Bewsher P.D., Reid I.W. Effects of widespread dermatitis and topical steroid therapy on thyroid function tests. Dermatologica 1988, 176:257-259.
36. Pagano G., Cavallo-Perin P., Cassader M., Bruno A., Ozzello A., Masciola P., Dall'omo A.M., Imbimbo B. An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects. The Journal of Clinical Investigation 1983, 72:1814-1820.
37. Rizza R.A., Mandarino L.J., Gerich J.E. Cortisol-induced insulin resistance in man: impaired suppression of glucose production and stimulation of glucose utilization due to a post-receptor detect of insulin action. The Journal of Clinical Endocrinology and Metabolism 1982, 54:131-138.
38. Rooney D.P., Neely R.D., Cullen C., Ennis C.N., Sheridan B., Atkinson A.B., Trimble E.R., Bell P.M. The effect of cortisol on glucose/glucose-6-phosphate cycle activity and insulin action. The Journal of Clinical Endocrinology and Metabolism 1993, 77:1180-1183.
39. Rubello D., Sonino N., Casara D., Girell M.E., Busnardo B., Boscaro M. Acute and chronic effects of high glucocorticoid levels on hypothalamic-pituitary-thyroid axis in man. Journal of Endocrinological Investigation 1992, 15:437-441.
40. Samuels M.H. Effects of variations in physiological cortisol levels on thyrotropin secretion in subjects with adrenal insufficiency: a clinical research center study. The Journal of Clinical Endocrinology and Metabolism 2000, 85:1388-1393.
41. Schneiter P., Tappy L. Kinetics of dexamethasone-induced alterations of glucose metabolism in healthy humans. American Journal of Physiology 1998, 275:E806-813.
42. Shamoon H., Soman V., Sherwin R.S. The influence of acute physiological increments of cortisol on fuel metabolism and insulin binding to monocytes in normal humans. The Journal of Clinical Endocrinology and Metabolism 1980, 50:495-501.
43. Spiess B.M., Nyikos S., Stummer E., Sahin A., Naegeli H. Systemic dexamethasone concentration in horses after continued topical treatment with an ophthalmic preparation of dexamethasone. American Journal of Veterinary Research 1999, 60:571-576.
44. Todd G.R., Acerini C.L., Buck J.J., Murphy N.P., Ross-Russell R., Warner J.T., McCance D.R. Acute adrenal crisis in asthmatics treated with high-dose fluticasone propionate. European Respiratory Journal 2002, 19:1207-1209.
45. Wajngot A., Khan A., Giacca A., Vranic M., Efendic S. Dexamethasone increases glucose cycling, but not glucose production, in healthy subjects. American Journal of Physiology 1990, 259:E626-632.
46. Wilber J.F., Utiger R.D. The effect of glucocorticoids on thyrotropin secretion. The Journal of Clinical Investigation 1969, 48:2096-2103.