Systemic dexamethasone concentration in horses after continued topical treatment with an ophthalmic preparation of dexamethasone

American Journal of Veterinary Research

Volumn 60, Issue 5, 1999, Pages 571-576

  Spiess, Bernhard M ^a   Nyikos, Sibylle ^a   Stummer, Eva ^a   Sahin, Ali ^a,b   Naegeli, Hanspeter ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b YUZUNCU YIL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; BODY WEIGHT; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG PENETRATION; DRUG URINE LEVEL; ENZYME IMMUNOASSAY; HORSE; NONHUMAN; STEROIDOGENESIS; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; DEXAMETHASONE; EYE; FEMALE; HORSES; MALE; METABOLIC CLEARANCE RATE; OINTMENTS; REGRESSION ANALYSIS;

EID: 0032896246     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Ferguson DC, Hoenig M. Glucocorticoids, mineralocorticoids, and steroid synthesis inhibitors. In: Adams HR, ed. Veterinary pharmacology and therapeutics. 7th ed. Ames, Iowa: Iowa State University Press, 1995;622-643.
2. Pugh DM. The trophic hormones and the endocrine regulators of metabolism. In: Brander CG, Pugh DM, Bywater RJ, et al, eds. Veterinary applied pharmacology and therapeutics. 5th ed. London: Bailliere Tindall, 1991;259-278.
3. May SA. Anti-inflammatory agents. In: Robinson NE, ed. Current therapy in equine medicine 3. Philadelphia: WB Saunders Co, 1992;14-18.
4. Friederich A, Schulz R, Meyer HHD. Use of enzyme immunoassay and reverse-phase high-performance liquid chromatography to detect and confirm identity of dexamethasone in equine blood. Am J Vet Res 1992;53:2213-2220.
5. Jones TDC. Equine periodic ophthalmia. Am J Vet Res 1942; 3:45-71.
6. Cross RSN. Equine periodic ophthalmia. Vet Rec 1966;78:8-13.
7. Bistner S, Show D. Uveitis in the horse. Compend Contin Educ Pract Vet 1980;2:35-43.
8. Cook CS, Peiffer RL, Harling DE. Equine recurrent uveitis. Equine Vet J 1983;2(Suppl):57-60.
9. Matthews AG, Handscombe MC. Uveitis in the horse: a review of the aetiological and immunophathological aspects of the disease. Equine Vet J 1983;2(Suppl):61-64.
10. Rebhun WC. Diagnosis and treatment of equine uveitis. J Am Vet Med Assoc 1979;175:803-808.
11. Riis RC. Equine ophthalmology. In: Gelatt KN, ed. Textbook of veterinary ophthalmology. Philadelphia: Lea & Febiger, 1981;569-605.
12. Halliwell RE, Brim TA, Hines MT, et al. Studies on equine recurrent uveitis. II. The role of infection with Leptospira interrogans serovar pomona. Curr Eye Res 1985;4:1033-1040.
13. Abrams K, Brooks DE. Equine recurrent uveitis: current concepts in diagnosis and treatment. Equine Pract 1990;12:27-35.
14. Spiess BM. Equine recurrent uveitis. In: Robinson NE, ed. Current therapy in equine medicine 4. Philadelphia: WB Saunders Co, 1997;363-366.
15. Spiess BM. Zur equinen rezidivierenden uveitis (ERU). Schweiz Arch Tierheilk 1997;139:126-133.
16. Slatter D. Fundamentals of veterinary ophthalmology. 2nd ed. Philadelphia: WB Saunders Co, 1990;328-333.
17. Miller TR. Punctate keratitis. In: Robinson NE, ed. Current therapy in equine medicine 3. Philadelphia: WB Saunders Co, 1992; 599-601.
18. Tobin T. Steroidal anti-inflammatory agents: the corticosteroid and ACTH. In: Tobin T, ed. Drugs and the performance horse. Springfield, Ill: Charles C Thomas Publishers, 1981;132-148.
19. Popot MA, Houghton E, Ginn A, et al. Cortisol concentrations in post competition horse urine: a French and British survey. Equine Vet J 1997;29:226-229.
20. Pick M. Doping im pferdesport und die problematik für den behandelnden tierarzt. Prakt Tierarztl 1993;7:613-620.
21. Fédération Equestre International. Prohibited substances. In: Veterinary regulations. 8th ed. Lausanne, Switzerland: Fédération Equestre International, 1998;108-111.
22. Klaus AM, Hapke HJ. Problems of doping in horse racing: pharmacokinetics of selected antiphlogistics/analgesics with doping effects. Dtsch Tierärztl Wschr 1996;101:301-340.
23. Friedrich A, Hagedorn HW, Schulz R. Detecting dexamethasone in horses. Tierarztl Praxis 1990;18:613-617.
24. Dumasia MC, Horner MW, Houghton E, et al. The urinary excretion and metabolism of dexamethasone in the horse. Biochem Soc Trans 1976;4:119-121.
25. Chapman DI, Moss MS, Whiteside J. The urinary excretion of synthetic corticosteroids by the horse. Vet Rec 1977;100:447-450.
26. Skrabalak DS, Maylin GA. Dexamethasone metabolism in the horse. Steroids 1982;39:233-244.
27. Toutain PL, Brandon RA, de Pomyers H, et al. Dexamethasone and prednisolone in the horse: pharmacokinetics and action on the adrenal gland. Am J Vet Res 1984;45:1750-1756.
28. Cunningham FE, Rogers S, Fischer JH, et al. The pharmacokinetics of dexamethasone in the Thoroughbred racehorse. J Vet Pharmacol Ther 1996;19:68-71.
29. Chen CL, Zhu D, Gillis KD, et al. Use of enzyme-linked immunosorbent assay and radioimmunoassay to determine serum and urine dexamethasone concentrations in Thoroughbreds after intravenous administration of the steroid. Am J Vet Res 1996;57:182-186.
30. Chen CL, Sailor JA, Collier J, et al. Synovial and serum levels of triamcinolone following intra-articular administration of triamcinolone acetonide in the horse. J Vet Pharmacol Ther 1992;15:240-246.
31. Sams RA, Hinchcliff KW. Drugs and performance. In: Hodgson DR, Rose RJ, eds. The athletic horse. Philadelphia: WB Saunders Co, 1994;439-467.
32. Houghton E, Teale P, Dumasia MC, et al. The use of capillary column gas chromatography and negative ion chemical ionization mass spectrometry to confirm the administration of synthetic corticosteroids to horses. Biomed Environ Mass Spectrom 1982;9:459-465.
33. Kayganich K, Watson JT, Kilts C, et al. Determination of plasma dexamethasone by chemical oxidation and electron capture negative ionization mass spectrometry. Biomed Environ Mass Spectrom 1990;19:341-347.
34. Mallinson ET, Dreas JS, Wilson, RT, et al. Determination of dexamethasone in liver and muscle by liquid chromatography and gas chromatography/mass spectrometry. J Agric Food Chem 1995,43: 140-145.