Effect of propranolol on word fluency in autism

Cognitive and Behavioral Neurology

Volumn 24, Issue 1, 2011, Pages 11-17

  Beversdorf, David Q ^a,b   Saklayen, Sanjida ^a,b   Higgins, Katherine F ^c   Bodner, Kimberly E ^a   Kanne, Stephen M ^b,d   Christ, Shawn E ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

autism; language; noradrenergic; propranolol; semantic

Indexed keywords

PLACEBO; PROPRANOLOL;

ADOLESCENT; ADULT; ARTICLE; AUTISM; BLOOD PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HEART RATE; HUMAN; INTELLIGENCE QUOTIENT; MALE; PHONETICS; PRIORITY JOURNAL; SEMANTICS; TASK PERFORMANCE; VERBAL BEHAVIOR; WECHSLER INTELLIGENCE SCALE;

ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; AUTISTIC DISORDER; FEMALE; HUMANS; LANGUAGE DISORDERS; MALE; MATCHED-PAIR ANALYSIS; NEURAL PATHWAYS; PROPRANOLOL; REFERENCE VALUES; SEMANTICS; STATISTICS, NONPARAMETRIC; VERBAL BEHAVIOR; YOUNG ADULT;

EID: 79955455512     PISSN: 15433633     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNN.0b013e318204d20e     Document Type: Article

References (51)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, Text Revision (DSM-IVTR). Washington, DC: American Psychiatric Association; 2000.
2. Myers SM, Johnson CP, American Academy of Pediatrics. Management of children with autism spectrum disorders. Pediatrics. 2007; 120:1162-1182. (Pubitemid 350085560)
3. Beversdorf DQ. Therapeutic interventions in autism: a review for primary care physicians. Missouri Med. 2008;105:390-395.
4. Hollander E, Bartz J, Chaplin W, et al. Oxytocin increases retention of social cognition in autism. Biol Psychiatry. 2007;61:498-503. (Pubitemid 46185336)
5. Chez MG, Burton Q, Dowling T, et al. Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J Child Neruol. 2007;22:574-579. (Pubitemid 46951501)
6. Erickson CA, Posey DJ, Stigler KA, et al. A retrospective study of memantine in children and adolescents with pervasive developmental disorders. Psychopharmacology. 2007;191:141-147. (Pubitemid 46294942)
7. Faigel HC. The effect of beta blockade on stress-induced cognitive dysfunction in adolescents. Clin Pediatr (Phila). 1991;30:441-445.
8. Lader M. Beta-adrenergic antagonists in neuropsychiatry: an update. J Clin Psychiatry. 1988;49:213-223.
9. Laverdue B, Boulenger JP. Medications beta-bloquantes et anxiete. Un interet therapeutique certain. [Beta-blocking drugs and anxiety. A proven therapeutic value]. L'Encephale. 1991;17:481-492.
10. Beversdorf DQ, Hughes JH, Steinberg BA, et al. Noradrenergic modulation of cognitive flexibility in problem solving. NeuroReport. 1999;10:2763-2767. (Pubitemid 30004101)
11. Beversdorf DQ, White DM, Cheever DC, et al. Central betaadrenergic blockers modulation of cognitive flexibility. Neuro-Report. 2002;13:2505-2507. (Pubitemid 36143552)
12. Hasselmo ME, Linster C, Patil M, et al. Noradrenergic suppression of synaptic transmission may influence cortical signal-to-noise ratio. J Neurophysiol. 1997;77:3326-3339. (Pubitemid 27290897)
13. Campbell HL, Tivarus ME, Hillier A, et al. Increased task difficulty results in greater impact of noradrenergic modulation of cognitive flexibility. Pharmacol Biochem Behav. 2008;88:222-229. (Pubitemid 350116249)
14. Alexander JK, Hillier A, Smith RM, et al. Noradrenergic modulation of cognitive flexibility during stress. J Cogn Neurosci. 2007; 19:468-478. (Pubitemid 46393574)
15. Kelley BJ, Yeager KR, Pepper TH, et al. The effect of propranolol on cognitive flexibility and memory in acute cocaine withdrawal. Neurocase. 2007;13:320-327.
16. Beversdorf DQ, Sharma UK, Phillips NN, et al. Effect of propranolol on naming in chronic Broca's aphasia with anomia. Neurocase. 2007;13:256-259. (Pubitemid 350153955)
17. Just MA, Cherkassky VL, Keller TA, et al. Cortical activation and synchronization during sentence comprehension in highfunctioning autism: evidence of underconnectivity. Brain. 2004;127: 1811-1821. (Pubitemid 39061557)
18. Koshino H, Carpenter PA, Minshew NJ, et al. Functional connectivity in an fMRI working memory task in high-functioning autism. Neuroimage. 2005;24:810-821. (Pubitemid 40094563)
19. Cohen IL. An artificial neural network analogue of learning in autism. Biol Psychiatry. 1994;36:5-20. (Pubitemid 24210119)
20. McClelland JL. The basis of hyperspecificity in autism: a preliminary suggestion based on properties of neural nets. J Autism Dev Disord. 2000;30:497-502.
21. Belmonte MK, Allen G, Beckel-Mitchener A, et al. Autism and abnormal development of brain connectivity. J Neurosci. 2004;24: 9228-9231. (Pubitemid 39426157)
22. Beversdorf DQ, Narayanan A, Hillier A, et al. Network model of decreased context utilization in autism spectrum disorder. J Autism Dev Disord. 2007;37:1040-1048. (Pubitemid 46976612)
23. Ratey JJ, Bemporad J, Sorgi P, et al. Brief report: open trial effects of beta-blockers on speech and social behaviors in 8 autistic adults. J Autism Dev Disord. 1987;17:439-446.
24. Beversdorf DQ, Carpenter AL, Miller RF, et al. Effect of propranolol on verbal problem solving in autism spectrum disorder. Neurocase. 2008;14:378-383.
25. Lord C, Rutter N, LeCouteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord. 1994;24:659-685. (Pubitemid 24309810)
26. Psychological Corporation. Wechsler Abbreviated Scale of Intelligence. San Antonio, TX: Psychological Corporation; 1999.
27. Spreen O, Strauss E. A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. 2nd ed. Oxford: Oxford University Press; 1998.
28. Troyer AK, Moscovitch M, Winocur G. Clustering and switching as two components of verbal fluency: evidence from younger and older healthy adults. Neuropsycology. 1997;11:138-146. (Pubitemid 27086868)
29. Tivarus ME, Hillier A, Schmalbrock P, et al. Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa. Brain Lang. 2008;104:42-50. (Pubitemid 350088964)
30. Narayanan A, White CA, Saklayen S, et al. Effect of propranolol on functional connectivity in autism spectrum disorder-a pilot study. Brain Imaging Behav. 2010;4:189-197.
31. Smith A, Nutt D. Noradrenaline and attention lapses. Nature. 1996; 380:291.
32. Coull JT, Frith CD, Dolan RJ, et al. The neural correlates of the noradrenergic modulation of human attention, arousal and learning. Eur J Neurosci. 1997;9:589-598. (Pubitemid 27144027)
33. Coull JT, Jones MEP, Egan TD, et al. Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. Neuroimage. 2004;22:315-322. (Pubitemid 38515837)
34. Robbins TW. Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications. Phil Trans R Soc Lon B Biol Sci. 2007;362:917-932. (Pubitemid 47056819)
35. Arnsten AF, Goldman-Rakic PS. Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey. Brain Res. 1984;306:9-18. (Pubitemid 14090440)
36. Barnes CA, Pompeiano M. Neurobiology of the locus coeruleus. Prog Brain Res. 1991;88:307-321.
37. Foster DJ, Good DC, Fowlkes A, et al. Atomoxetine enhances a short-term model of plasticity in humans. Arch Phys Med Rehabil. 2006;87:216-221. (Pubitemid 43151296)
38. Chamberlain SR, Müller U, Blackwell AD, et al. Neurochemical modulation of response inhibition and probabilistic learning in humans. Science. 2006;311:861-863. (Pubitemid 43228852)
39. Chamberlain SR, Müller U, Blackwell AD, et al. Noradrenergic modulation of working memory and emotional memory in humans. Psychopharmacology. 2006;188:397-407. (Pubitemid 46758959)
40. Heaton RK. Wisconsin Card Sort Test Manual. Odessa, FL: Psychological Assessment Resources; 1981.
41. Usher M, Cohen JD, Servan-Schreiber D, et al. The role of locus coeruleus in the regulation of cognitive performance. Science. 1999; 283:549-554.
42. Aston-Jones G, Cohen JD. An integrative theory of locus coeruleusnorepinephrine function: adaptive gain and optimal performance. Annu Rev Neurosci. 2005;28:403-450. (Pubitemid 41098911)
43. Lapiz MDS, Morilak DA. Noradrenergic modulation of cognitive function in rat medial prefrontal cortex as measured by attentional set shifting capability. Neuroscience. 2006;137: 1039-1049. (Pubitemid 43053965)
44. Lake CR, Ziegler MG, Murphy DL. Increased norepinephrine levels and decreased dopamine-beta-hydroxylase activity in primary autism. Arch Gen Psychiatry. 1977;34:553-556. (Pubitemid 8108954)
45. Launay J-M, Bursztejn C, Ferrari P, et al. Catecholamines metabolism in infantile autism: a controlled study of 22 autistic children. J Autism Dev Disord. 1987;17:333-347.
46. Barthelemy C, Bruneau N, Cottet-Eymard JM, et al. Urinary free and conjugated catecholamines and metabolites in autistic children. J Autism Dev Disord. 1998;18:583-591.
47. Martineau J, Barthelemy C, Jouve J, et al. Monoamines (serotonin and catecholamines) and their derivatives in infantile autism: agerelated changes and drug effects. Dev Med Child Neurol. 1992;34: 593-603.
48. Minderaa RB, Anderson GM, Volkmar FR, et al. Noradrenergic and adrenergic functioning in autism. Biol Psychiatry. 1994;36: 237-241. (Pubitemid 24278299)
49. MartchekM, Thevarkunnel S, Bauman M, et al. Lack of evidence of neuropathology in the locus coeruleus in autism. Acta Neuropathologica. 2006;111:497-499.
50. Curran LK, Newschaffer CJ, Lee L, et al. Behaviors associated with fever in children with autism spectrum disorders. Pediatrics. 2007;120:e1386-e1392. (Pubitemid 350223656)
51. Mehler MF, Purpura DP. Autism, fever, epigenetics and the locus coeruleus. Brain Res Rev. 2009;59:388-392.