Effect of propranolol on functional connectivity in autism spectrum disorder-A pilot study

Brain Imaging and Behavior

Volumn 4, Issue 2, 2010, Pages 189-197

  Narayanan, Ananth ^a,b   White, Catherine A ^a   Saklayen, Sanjida ^a,b,c   Scaduto, Mary J ^c   Carpenter, Allen L ^a   Abduljalil, Amir ^a   Schmalbrock, Petra ^a   Beversdorf, David Q ^b,d  

^a OHIO STATE UNIVERSITY   (United States)

^b University of Missouri   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

Asperger syndrome; Autism; Functional connectivity; Language; Noradrenergic; Propranolol

Indexed keywords

NADOLOL; PLACEBO; PROPRANOLOL;

ADULT; ARTICLE; AUTISM; BRAIN REGION; CLINICAL ARTICLE; CLINICAL TRIAL; DECISION MAKING; DRUG EFFECT; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMODYNAMIC MONITORING; HUMAN; MALE; MOLECULAR INTERACTION; NERVE CELL NETWORK; PILOT STUDY; PRIORITY JOURNAL; TASK PERFORMANCE; VERBAL BEHAVIOR;

ADRENERGIC BETA-ANTAGONISTS; ADULT; BRAIN; BRAIN MAPPING; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; DECISION MAKING; FEMALE; HUMANS; LANGUAGE TESTS; MAGNETIC RESONANCE IMAGING; MALE; NADOLOL; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; PHONETICS; PILOT PROJECTS; PROPRANOLOL; YOUNG ADULT;

EID: 77953544512     PISSN: 19317557     EISSN: 19317565     Source Type: Journal    
DOI: 10.1007/s11682-010-9098-8     Document Type: Article

References (46)

1. Alexander, J. K., Hillier, A., Smith, R. M., Tivarus, M. E., & Beversdorf, D. Q. (2007). Beta-adrenergic modulation of cognitive flexibility during stress. Journal of Cognitive Neuroscience, 19(3), 468-478, [Pubmed: 17335395].
2. Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a 'theory of mind'? Cognition, 21(1), 37-46, [Pubmed: 2934210].
3. Bauman, M., & Kemper, T. L. (1985). Histoanatomic observations of the brain in early infantile autism. Neurology, 35(6), 866-874, [Pubmed: 4000488].
4. Bauman, M., & Kemper, T. (1994). The neurobiology of autism. Baltimore: Johns Hopkins.
5. Beversdorf, D. Q., Ratcliffe, N. R., Rhodes, C. H., & Reeves, A. G. (1997). Pure alexia: clinical-pathologic evidence for a lateralized visual language association cortex. Clinical Neuropathology, 16(6), 328-331, [Pubmed: 9401800].
6. Beversdorf, D. Q., Anderson, J. M., Manning, S. E., Anderson, S. L., Nordgren, R. E., Felopulos, G. J., et al. (1998). The effect of semantic and emotional context on written recall for verbal language in high functioning adults with autism spectrum disorder. Journal of Neurology, Neurosurgery, and Psychiatry, 65(5), 685-692, [Pubmed: 9810938].
7. Beversdorf, D. Q., Hughes, J. D., Steinberg, B. A., Lewis, L. D., & Heilman, K. M. (1999). Noradrenergic modulation of cognitive flexibility in problem solving. NeuroReport, 10(13), 2763-2767, [Pubmed: 10511436].
8. Beversdorf, D. Q., Smith, B. W., Crucian, G. P., Anderson, J. M., Keillor, J. M., Barrett, A. M., et al. (2000). Increased discrimination of "false memories" in autism spectrum disorder. Proceedings of the National Academy of Sciences of the United States of America, 97(15), 8734-8737, [Pubmed: 10900024].
9. Beversdorf, D. Q., White, D. M., Chever, D. C., Hughes, J. D., & Bornstein, R. A. (2002). Central beta-adrenergic blockers modulation of cognitive flexibility. NeuroReport, 13(18), 2505-2507, [Pubmed: 12499857].
10. Beversdorf, D. Q., Carpenter, A. L., Miller, R. F., Cios, J. S., & Hillier, A. (2008). Effect of propranolol on verbal problem solving in autism spectrum disorder. Neurocase, 14(4), 378-383, [Pubmed: 18766980].
11. Bookheimer, S. (2002). Functional MRI of language: new approaches to understanding the cortical organization of semantic processing. Annual Review of Neuroscience, 25, 151-188, [Pubmed: 12052907].
12. Campbell, H. L., Tivarus, M. E., Hillier, A., & Beversdorf, D. Q. (2008). Increased task difficulty results in greater impact of noradrenergic modulation of cognitive flexibility. Pharmacology, Biochemistry and Behavior, 88(3), 222-229, [Pubmed: 17884154].
13. Carpenter, A. (1992). Autistic adulthood: A challenging journey. In E. Schopler & G. B. Mesibov (Eds.), High-functioning individuals with autism (pp. 289-294). New York: Plenum.
14. Chamberlain, S. R., Müller, U., Blackwell, A. D., Robbins, T. W., & Sahakian, B. J. (2006). Noradrenergic modulation of working memory and emotional memory in humans. Psychopharmacology, 188, 397-407, [Pubmed 16642355].
15. Curran, L. K., Newschaffer, C. J., Lee, L. C., Crawford, S. O., Johnston, M. V., & Zimmerman, A. W. (2007). Behaviors associated with fever in children with autism spectrum disorders. Pediatrics, 120(6), e1386-e1392, [Pubmed: 18055656].
16. Fotheringham, J. B. (1991). Autism: Its primary psychological and neurological deficit. Canadian Journal of Psychiatry, 36(9), 686-692, [Pubmed: 1773407].
17. Friston, K. J. (1994). Functional and effective connectivity in neuroimaging: a synthesis. Human Brain Mapping, 2, 56-78.
18. Frith, U., & Happé, F. G. E. (1994). Autism: Beyond "theory of mind". Cognition, 50(1-3), 115-132, [Pubmed: 8039356].
19. Gilliam, J. E. (2001). Gilliam Asperger's disorder scale. Austin: ProEd.
20. Happé, F. G. E. (1994). An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. Journal of Autism and Developmental Disorders, 24(2), 129-154, [Pubmed: 8040158].
21. Hasselmo, M. E., Linster, C., Patil, M., Ma, D., & Cekic, M. (1997). Noradrenergic suppression of synaptic transmission may influence cortical signal-to-noise ratio. Journal of Neurophysiology, 77(6), 3326-3339, [Pubmed: 9212278].
22. Hobson, R. P. (1991). Methodological issues for experiments on autistic individuals' perception and understanding of emotion. Journal of Child Psychology and Psychiatry, 32(7), 1135-1158, [Pubmed: 1787140].
23. Hobson, R. P. (1993). Understanding persons: The role of affect. In S. Baron-Cohen, H. Tager-Flusberg, & D. J. Cohen (Eds.), Understanding other minds: Perspectives from autism (pp. 208-227). Oxford: Oxford University Press.
24. Just, M. A., Cherkassky, V. L., Keller, T. A., & Minshew, N. J. (2004). Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain, 127(8), 1811-1821, [Pubmed: 15215213].
25. Kelley, B. J., Yeager, K. R., Pepper, T. H., Bornstein, R. A., & Beversdorf, D. Q. (2007). The effect of propranolol on cognitive flexibility and memory in acute cocaine withdrawal. Neurocase, 13(5), 320-327, [Pubmed: 18781429].
26. Kleinhans, N. M., Muller, R. A., Cohen, D. N., & Courchesne, E. (2008). Atypical functional lateralization of language in autism spectrum disorders. Brain Research, 1221, 115-125, [Pubmed: 18555209].
27. Koshino, H., Carpenter, P. A., Minshew, N. J., Cherkassky, V. L., Keller, T. A., & Just, M. A. (2005). Functional connectivity in an fMRI working memory task in high-functioning autism. Neuroimage, 24(3), 810-821, [Pubmed: 15652316].
28. Lake, C. R., Ziegler, M. G., & Murphy, D. L. (1977). Increased norepinephrine levels and decreased dopamine-beta-hydroxylase activity in primary autism. Archives of General Psychiatry, 34, 553-556, [Pubmed: 558741].
29. Launay, J.-M., Bursztejn, C., Ferrari, P., Dreux, C., Braconnier, A., Zarifian, E., et al. (1987). Catecholamines metabolism in infantile autism: a controlled study of 22 autistic children. Journal of Autism and Developmental Disorders, 17, 333-347, [Pubmed: 3654486].
30. Lee, J. E., Bigler, E. D., Alexander, A. L., Lazar, M., DuBray, M. B., Chung, M. K., et al. (2007). Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism. Neuroscience Letters, 424(2), 127-132, [Pubmed: 17714869].
31. Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659-685, [Pubmed: 7814313].
32. Martchek, M., Thevarkunnel, S., Bauman, M., Blatt, G., & Kemper, T. (2006). Lack of evidence of neuropathology in the locus coeruleus in autism. Acta Neuropathologica, 111(5), 497-499, [Pubmed: 16596425].
33. McDermott, K. B., Petersen, S. E., Watson, J. M., & Ojemann, J. G. (2003). A procedure for identifying regions preferentially activated by attention to semantic and phonological relations using functional magnetic resonance imaging. Neuropsychologia, 41(3), 293-303, [Pubmed: 12457755].
34. Mehler, M. F., & Purpura, D. P. (2009). Autism, fever, epigenetics and the locus coeruleus. Brain Research Reviews, 59(2), 388-392, [Pubmed: 19059284].
35. Minderaa, R. B., Anderson, G. M., Volkmar, F. R., Akkerhuis, G. W., & Cohen, D. J. (1994). Noradrenergic and adrenergic functioning in autism. Biological Psychiatry, 36(4), 237-241, [Pubmed: 7986888].
36. Minshew, N. J., & Goldstein, G. (2001). The pattern of intact and impaired memory functions in autism. Journal of Child Psychology and Psychiatry, 42(8), 1095-1101, [Pubmed: 11806691].
37. Morgan, H. (1996). Underpinning philosophy in the provision of services for adults with autism: A critique of global values related to specific practice. In H. Morgan (Ed.), Adults with autism: A guide to theory and practice (pp. 31-52). Cambridge: Cambridge University Press.
38. Ramos, B. P., Colgan, L., Nou, E., Ovadia, S., Wilson, S. R., & Arnsten, A. F. T. (2005). The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys. Biological Psychiatry, 58, 894-900, [Pubmed: 16043136].
39. Ramos, B. P., Colgan, L. A., Nou, E., & Arnsten, A. F. T. (2008). β2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animals. Neurobiology of Aging, 29, 1060-1069, [Pubmed: 17363115].
40. Ratey, J. J., Bemporad, J., Sorgi, P., Bick, P., Polakoff, S., O'Driscoll, G., et al. (1987). Open trial effects of beta-blockers on speech and social behaviors in 8 autistic adults. Journal of Autism and Developmental Disorders, 17(3), 439-446, [Pubmed: 3654495].
41. Rumsey, J. M. (1985). Conceptual problem-solving in highly verbal, nonretarded autistic men. Journal of Autism and Developmental Disorders, 15(1), 23-36, [Pubmed: 3980427].
42. Rumsey, J. M., & Hamburger, S. D. (1988). Neuropsychological findings in high-functioning men with infantile autism, residual state. Journal of Clinical and Experimental Neuropsychology, 10(2), 201-221, [Pubmed: 3350920].
43. Rumsey, J. M., & Hamburger, S. D. (1990). Neuropsychological divergence of high-level autism and severe dyslexia. Journal of Autism and Developmental Disorders, 20(2), 155-168, [Pubmed: 2347817].
44. Schmidt, G. L., Kimel, L. K., Winterrowd, E., Pennington, B. F., Hepburn, S. L., & Rojas, D. C. (2008). Impairments in phonological processing and nonverbal intellectual function in parents of children with autism. Journal of Clinical and Experimental Neuropsychology, 30(5), 557-567, [Pubmed: 18569254].
45. Tivarus, M. E., Hillier, A., Schmalbrock, P., & Beversdorf, D. Q. (2008). Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa. Brain and Language, 104(1), 42-50, [Pubmed: 17418888].
46. Williams, D. L., Goldstein, G., & Minshew, N. J. (2006). Neuropsychologic functioning in children with autism: further evidence for disordered complex information processing. Child Neuropsychology, 12, 279-298, [Pubmed: 16911973].