Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling

Toxicological Sciences

Volumn 121, Issue 1, 2011, Pages 177-190

  Kuo, Po Lin ^a   Hsu, Ya Ling ^a   Huang, Ming Shyan ^a   Chiang, Shang Lun ^a   Ko, Ying Chin ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Areca nut; Asthma; KLF5; Migration; Proliferation

Indexed keywords

ARECOLINE; CYCLIN D; INTEGRIN LINKED KINASE; INTERLEUKIN 8; KRUPPEL LIKE FACTOR 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; RAF PROTEIN; RANTES; RECOMBINANT INTERLEUKIN 8;

AIRWAY REMODELING; ARTICLE; ASTHMA; BETEL NUT; BRONCHUS MUCOSA; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE FIBER; T LYMPHOCYTE;

ARECA; ARECA CATECHU;

EID: 79955445335     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr030     Document Type: Article

References (34)

1. Benayoun, L., Druilhe, A., Dombret, M. C., Aubier, M., and Pretolani, M. (2003). Airway structural alterations selectively associated with severe asthma. Am. J. Respir. Crit. Care Med. 167, 1360-1368.
2. Bergeron, C., Al-Ramli, W., and Hamid, Q. (2009). Remodeling in asthma. Proc. Am. Thorac. Soc. 6, 301-305.
3. Bialkowska, A. B., Du, Y., Fu, H., and Yang, V. W. (2009). Identification of novel small-molecule compounds that inhibit the proproliferative Kruppellike factor 5 in colorectal cancer cells by high-throughput screening. Mol. Cancer Ther. 8, 563-570.
4. Bossé, Y., Thompson, C., McMahon, S., Dubois, C. M., Stankova, J., and Rola-Pleszczynski, M. (2008). Leukotriene D4-induced, epithelial cellderived transforming growth factor beta1 in human bronchial smooth muscle cell proliferation. Clin. Exp. Allergy 38, 113-121.
5. Chiang, S. L., Chen, P. H., Lee, C. H., Ko, A. M., Lee, K. W., Lin, Y. C., Ho, P. S., Tu, H. P., Wu, D. C., Shieh, T. Y., et al. (2008). Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. Cancer Res. 68, 8489-8498.
6. Chiang, S. L., Jiang, S. S., Wang, Y. J., Chiang, H. C., Chen, P. H., Tu, H. P., Ho, K. Y., Tsai, Y. S., Chang, I. S., and Ko, Y. C. (2007). Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling. Toxicol. Sci. 100, 66-74.
7. Davies, D. E. (2009). The role of the epithelium in airway remodeling in asthma. Proc. Am. Thorac. Soc. 6, 678-682.
8. Dekkers, B. G., Maarsingh, H., Meurs, H., and Gosens, R. (2009). Airway structural components drive airway smooth muscle remodeling in asthma. Proc. Am. Thorac. Soc. 6, 683-692.
9. Dong, J. T., and Chen, C. (2009). Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell Mol. Life Sci. 66, 2691-2706.
10. Duan, W., and Wong, W. S. (2006). Targeting mitogen-activated protein kinases for asthma. Curr. Drug Targets 7, 691-698.
11. Gerthoffer, W. T., and Singer, C. A. (2003). MAPK regulation of gene expression in airway smooth muscle. Respir. Physiol. Neurobiol. 137, 237-250.
12. Gupta, P. C., and Ray, C. S. (2004). Epidemiology of betel quid usage. Ann. Acad. Med. Singapore 33, 31-36.
13. He, M., Han, M., Zheng, B., Shu, Y. N., and Wen, J. K. (2009). Angiotensin II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cells. J. Biochem. 146, 683-691.
14. Holgate, S. T., Roberts, G., Arshad, H. S., Howarth, P. H., and Davies, D. E. (2009). The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proc. Am. Thorac. Soc. 6, 655-659.
15. Hosseinzadeh, S., Pacey, A. A., and Eley, A. (2003). Chlamydia trachomatisinduced death of human spermatozoa is caused primarily by lipopolysaccharide. J. Med. Microbiol. 52, 193-200.
16. Hsu, Y. L., Hung, J. Y., Ko, Y. C., Hung, C. H., Huang, M. S., and Kuo, P. L. (2010). Phospholipase D signaling pathway is involved in lung cancerderived IL-8 increased osteoclastogenesis. Carcinogenesis 31, 587-596.
17. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. (2004). Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines. IARC Monogr. Eval. Carcinog. Risks Hum. 85, 1-334.
18. Kiyingi, K. S. (1991). Betel-nut chewing may aggravate asthma. P N G Med. J. 34, 117-121.
19. Lara, V. S., Figueiredo, F., da Silva, T. A., and Cunha, F. Q. (2003). Dentininduced in vivo inflammatory response and in vitro activation of murine macrophages. J. Dent. Res. 82, 460-465.
20. Liu, Y., Wen, J. K., Dong, L. H., Zheng, B., and Han, M. (2010). Krüppel-like factor (KLF) 5 mediates cyclin D1 expression and cell proliferation via interaction with c-Jun in AngII-induced VSMCs. Acta Pharmacol. Sin. 31, 10-18.
21. Lord, G. A., Lim, C. K., Warnakulasuriya, S., and Peters, T. J. (2002). Chemical and analytical aspects of areca nut. Addict. Biol. 7, 99-102.
22. Makinde, T., Murphy, R. F., and Agrawal, D. K. (2007). The regulatory role of TGF-beta in airway remodeling in asthma. Immunol. Cell Biol. 85, 348-356.
23. Mori, A., Moser, C., Lang, S. A., Hackl, C., Gottfried, E., Kreutz, M., Schlitt, H. J., Geissler, E. K., and Stoeltzing, O. (2009). Up-regulation of Krüppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. Mol. Cancer Res. 7, 1390-1398.
24. Nandan, M. O., McConnell, B. B., Ghaleb, A. M., Bialkowska, A. B., Sheng, H., Shao, J., Babbin, B. A., Robine, S., and Yang, V. W. (2008). Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis. Gastroenterology 134, 120-130.
25. Oishi, Y., Manabe, I., Tobe, K., Tsushima, K., Shindo, T., Fujiu, K., Nishimura, G., Maemura, K., Yamauchi, T., Kubota, N., et al. (2005). Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 1, 27-39.
26. Pera, T., Gosens, R., Lesterhuis, A. H., Sami, R., Toorn, M., Zaagsma, J., and Meurs, H. (2010). Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. Respir. Res. 11, 48.
27. Prokopczyk, B., Bertinato, P., and Hoffmann, D. (1998). Cyanoethylation of DNA in vivo by 3-(methylnitrosamino)propionitrile, an Areca-derived carcinogen. Cancer Res. 48, 6780-6784.
28. Sundqvist, K., Liu, Y., Erhardt, P., Nair, J., Bartsch, H., and Grafström, R. C. (1991). Areca-nut toxicity in cultured human buccal epithelial cells. IARC Sci. Publ. 105, 281-285.
29. Suzuki, T., Sawaki, D., Aizawa, K., Munemasa, Y., Matsumura, T., Ishida, J., and Nagai, R. (2009). Kruppel-like factor 5 shows proliferation-specific roles in vascular remodeling, direct stimulation of cell growth, and inhibition of apoptosis. J. Biol. Chem. 284, 9549-9557.
30. Taylor, R. F., al-Jarad, N., John, L. M., Conroy, D. M., and Barnes, N. C. (1992). Betel-nut chewing and asthma. Lancet 339, 1134-1136.
31. Wan, H., Luo, F., Wert, S. E., Zhang, L., Xu, Y., Ikegami, M., Maeda, Y., Bell, S. M., and Whitsett, J. A. (2008). Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development 135, 2563-2572.
32. Wenke, G., Rivenson, A., and Hoffmann, D. (1984). A study of betel quid carcinogenesis. 3. 3-(Methylnitrosamino)-propionitrile, a powerful carcinogen in F344 rats. Carcinogenesis 5, 1137-1140.
33. Yang, Y., Tetreault, M. P., Yermolina, Y. A., Goldstein, B. G., and Katz, J. P. (2008). Krüppel-like factor 5 controls keratinocyte migration via the integrinlinked kinase. J. Biol. Chem. 283, 18812-18820.
34. Yao, E. H., Fukuda, N., Ueno, T., Tsunemi, A., Endo, M., and Matsumoto, K. (2008). Complement 3 activates the KLF5 gene in rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 367, 468-473.