Phospholipase D signaling pathway is involved in lung cancer-derived IL-8 increased osteoclastogenesis

Carcinogenesis

Volumn 31, Issue 4, 2010, Pages 587-596

  Hsu, Ya Ling ^a   Hung, Jen Yu ^a,b   Ko, Ying Chin ^c,d   Hung, Chih Hsing ^a,b   Huang, Ming Shyan ^a,b,c   Kuo, Po Lin ^b,c,e  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 8; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE D; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; RECOMBINANT INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TNFSF11 PROTEIN, HUMAN;

ARTICLE; BONE METASTASIS; CANCER INVASION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG CANCER; OSTEOCLAST; OSTEOCLASTOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; BONE TUMOR; CELL CULTURE; LUNG TUMOR; METASTASIS; PATHOLOGY; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BONE NEOPLASMS; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERLEUKIN-8; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; OSTEOCLASTS; PHOSPHOLIPASE D; PROTEIN KINASE C-ALPHA; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RANK LIGAND; SIGNAL TRANSDUCTION;

EID: 77950905387     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq030     Document Type: Article

References (41)

1. Al Husaini, H. et al. (2009) Prevention and management of bone metastases in lung cancer: a review. J. Thorac. Oncol., 4, 251-259.
2. Hirsh, V. et al. (2008) Zoledronic acid and survival in patients with metastatic bone disease from lung cancer and elevated markers of osteoclast activity. J. Thorac. Oncol., 3, 228-236.
3. Pawelek, J.M. et al. (2008) The cancer cell-leukocyte fusion theory of metastasis. Adv. Cancer Res., 101, 397-444.
4. Burger, J.A. et al. (2009) CXCR4 chemokine receptor antagonists: perspectives in SCLC. Expert Opin. Investig. Drugs, 18, 481-490.
5. Meydan, N. et al. (2006) Brown tumors mimicking bone metastases. J. Natl Med. Assoc., 98, 950-953.
6. Cai, Z. et al. (2009) Monocyte chemotactic protein 1 promotes lung cancerinduced bone resorptive lesions in vivo. Neoplasia, 11, 228-236.
7. Waugh, D.J. et al. (2008) The interleukin-8 pathway in cancer. Clin. Cancer Res., 14, 6735-6741.
8. Bendre, M.S. et al. (2005) Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway. Cancer Res., 65, 11001-11009.
9. Martin, D. et al. (2009) CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex. J. Biol. Chem., 284, 6038-6042.
10. MacManus, C.F. et al. (2007) Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. Mol. Cancer Res., 5, 737-748.
11. Wangpaichitr, M. et al. (2008) Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines. Mol. Cancer Ther., 7, 1506-1513.
12. Kawamura, N. et al. (2007) Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One, 2, e1058.
13. Wong, B.R. et al. (1999) TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol. Cell, 4, 1041-1049.
14. Iyer, S.S. et al. (2006) Phospholipase D1 regulates phagocyte adhesion. J. Immunol., 176, 3686-3696.
15. Lehman, N. et al. (2006) Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood, 108, 3564-3572.
16. Di Fulvio, M. et al. (2005) Phospholipase D (PLD) gene expression in human neutrophils and HL-60 differentiation. J. Leukoc. Biol., 77, 999- 1007.
17. Kam, Y. et al. (2004) Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid. FASEB J., 18, 311-319.
18. Gills, J.J. et al. (2006) Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt. Mol. Cancer Ther., 5, 713-722.
19. Mackay, H.J. et al. (2007) Targeting the protein kinase C family: are we there yet? Nat. Rev. Cancer, 7, 554-562.
20. Lee, S.W. et al. (2003) Participation of protein kinase C beta in osteoclast differentiation and function. Bone, 32, 217-227.
21. Rucci, N. et al. (2005) A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. J. Cell Sci., 118, 3263-3275.
22. Yang, C.R. et al. (2004) Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells. Cell Death Differ., 11 (suppl. 1), S97-S107.
23. Roato, I. et al. (2008) Spontaneous osteoclastogenesis is a predictive factor for bone metastases from non-small cell lung cancer. Lung Cancer, 61, 109-116.
24. L'Heureux, G.P. et al. (1995) Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity. Blood, 85, 522-531.
25. Hui, L. et al. (2004) Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Mol. Cell. Biol., 24, 5677-5686.
26. Thimmaiah, K.N. et al. (2005) Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J. Biol. Chem., 280, 31924-31935.
27. Zhu, Y.M. et al. (2004) Interleukin-8/CXCL8 is a growth factor for human lung cancer cells. Br. J. Cancer, 91, 1970-1976.
28. Millar, H.J. et al. (2008) Circulating human interleukin-8 as an indicator of cancer progression in a nude rat orthotopic human non-small cell lung carcinoma model. Cancer Epidemiol. Biomarkers Prev., 17, 2180-2187.
29. Orditura, M. et al. (2002) Elevated serum levels of interleukin-8 in advanced non-small cell lung cancer patients: relationship with prognosis. J. Interferon Cytokine Res., 22, 1129-1135.
30. Sugatani, T. et al. (2005) Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J. Biol. Chem., 280, 3583-3589.
31. Sanchez, C.P. et al. (2009) Bone growth during rapamycin therapy in young rats. BMC Pediatr., 9, 3.
32. Pereverzev, A. et al. (2008) Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway. Bone, 42, 150-61.
33. Duran, A. et al. (2004) The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell, 6, 303-309.
34. Sozzani, S. et al. (1994) Activation of phospholipase D by interleukin-8 in human neutrophils. Blood, 84, 3895-3901.
35. Park, M.H. et al. (2009) Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways. Carcinogenesis, 30, 356-365. 596
36. Banno, Y. et al. (2005) Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells. J. Biol. Chem., 280, 16319-16324.
37. Yoon, M.S. et al. (2008) PLD regulates myoblast differentiation through the mTOR-IGF2 pathway. J. Cell Sci., 121, 282-289.
38. Komati, H. et al. (2005) Phospholipase D is involved in myogenic differentiation through remodeling of actin cytoskeleton. Mol. Biol. Cell, 16, 1232-1244.
39. Bollag, W.B. et al. (2005) Phospholipase d signaling and extracellular signal-regulated kinase-1 and -2 phosphorylation (activation) are required for maximal phorbol ester-induced transglutaminase activity, a marker of keratinocyte differentiation. J. Pharmacol. Exp. Ther., 312, 1223-1231.
40. Kim, J. et al. (2006) Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10. Cancer Res., 66, 784-793.
41. Chen, Y. et al. (2005) Alternative phospholipase D/mTOR survival signal in human breast cancer cells. Oncogene, 24, 672-679.