Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): Synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl) propanoates

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2778-2791

  Gomaa, Mohamed S ^a   Bridgens, Caroline E ^b   Aboraia, Ahmed S ^a   Veal, Gareth J ^b   Redfern, Christopher P F ^b   Brancale, Andrea ^a   Armstrong, Jane L ^c   Simons, Claire ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 IMIDAZOL 1 YL 2 METHYL 3 [4 (NAPHTHALEN 2 YLAMINO)PHENYL]PROPIONIC ACID METHYL ESTER; CYTOCHROME P450 26A1; CYTOCHROME P450 INHIBITOR; LIAROZOLE; PHENYLPROPIONIC ACID DERIVATIVE; R 116010; RETINOIC ACID; TALAROZOLE; UNCLASSIFIED DRUG;

AMES TEST; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG SCREENING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; NEUROBLASTOMA CELL; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROPANE; RNA, MESSENGER; STEREOISOMERISM;

EID: 79955433252     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101583w     Document Type: Article

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