Allelic imbalance of the TGFΒR1 is not a major contributor to the genetic predisposition to colorectal cancer

British Journal of Cancer

Volumn 104, Issue 9, 2011, Pages 1517-1518

  Abadie, C ^a   Killian, A ^a   Tinat, J ^a   Bougeard, M ^a   Medhaoui, D ^a   Cailleux, A F ^b   Baert Desurmont, S ^a   Frebourg, T ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ALLELIC IMBALANCE; CANCER RISK; COLORECTAL CANCER; FAMILY HISTORY; GENETIC PREDISPOSITION; GENOTYPE; GROUPS BY AGE; HUMAN; LETTER; MULTIPLE CANCER; PATIENT SELECTION; PRIORITY JOURNAL; RISK FACTOR;

ADENOMATOUS POLYPOSIS COLI; ADULT; AGE OF ONSET; ALLELIC IMBALANCE; CARCINOMA; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; PROSPECTIVE STUDIES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 79955429570     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.124     Document Type: Letter

References (6)

1. Carvajal-Carmona LG, Churchman M, Bonilla C, Walther A, Lefevre JH, Kerr D, Dunlop M, Houlston R, Bodmer WF, Tomlinson I (2010) Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition. Proc Natl Acad Sci USA 107: 7858-7862
2. Guda K, Natale L, Lutterbaugh J, Wiesner GL, Lewis S, Tanner SM, Tomsic J, Valle L, de la Chapelle A, Elston RC, Willis J, Markowitz SD (2009) Infrequent detection of germline allele-specific expression of TGFbR1 in lymphoblasts and tissues of colon cancer patients. Cancer Res 69: 4959-4961
3. Pasche B, Wisinski KB, Sadim M, Kaklamani V, Pennison MJ, Zeng Q, Bellam N, Zimmerman J, Yi N, Zhang K, Baron J, Stram DO, Hayes MG (2010) Constitutively decreased TGFbR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFbR1 SNPs. J Exp Clin Cancer Res 29: 57
4. Segú? N, Stevens KN, Guinó E, Rozek LS, Moreno VR, Capellá G, Gruber SB, Valle L (2011) No association between germline allele-specific expression of TGFBR1 and colorectal cancer risk in Caucasian and Ashkenazi populations. Br J Cancer 104(4): 735-740
5. Tomsic J, Guda K, Liyanarachchi S, Hampel H, Natale L, Markowitz SD, Tanner SM, de la Chapelle A (2010) Allele-specific expression of TGFbR1 in colon cancer patients. Carcinogenesis 31(10): 1800-1804
6. Valle L, Serena-Acedo T, Liyanarachchi S, Hampel H, Comeras I, Li Z, Zeng Q, Zhang HT, Pennison MJ, Sadim M, Pasche B, Tanner SM, de la Chapelle A (2008) Germline allele-specific expression of TGFbR1 confers an increased risk of colorectal cancer. Science 321: 1361-1365