Gastroprotective and antidepressant effects of a new zinc(II)-curcumin complex in rodent models of gastric ulcer and depression induced by stresses

Pharmacology Biochemistry and Behavior

Volumn 99, Issue 1, 2011, Pages 66-74

  Mei, Xueting ^a   Xu, Donghui ^a   Xu, Sika ^a   Zheng, Yanping ^a   Xu, Shibo ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Antidepressant; Antiulcer; Curcumin; Synergistic effect; Zinc; Zn(II) curcumin complex

Indexed keywords

5 HYDROXYTRYPTOPHAN; ANTIDEPRESSANT AGENT; ANTIULCER AGENT; CATALASE; CURCUMIN; FLUOXETINE; HEAT SHOCK PROTEIN 70; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LANSOPRAZOLE; MALONALDEHYDE; MESSENGER RNA; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ZINC COMPLEX; ZINC CURCUMIN COMPLEX;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; COLD STRESS; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVITY; EXPERIMENTAL TEST; FORCED SWIMMING TEST; GENE EXPRESSION; HEAD MOVEMENT; HEAD TWITCH TEST; IMMOBILIZATION STRESS; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; TAIL SUSPENSION TEST;

ANIMALS; ANTIDEPRESSIVE AGENTS; CURCUMIN; DEPRESSION; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; MALE; MICE; PROTECTIVE AGENTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER; STRESS, PSYCHOLOGICAL; ZINC;

CURCUMA; MUS; RATTUS; RODENTIA;

EID: 79955428361     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.04.002     Document Type: Article

References (59)

1. H. Aebi Catalase in vitro Methods Enzymol 105 1984 121 126
2. R. Ambra, E. Mocchegiani, R. Giacconi, R. Canali, A. Rinna, and M. Malavolta Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation Exp Gerontol 39 2004 1475 1484 (Pubitemid 39410547)
3. T.L. Bale Sensitivity to stress: dysregulation of CRF pathways and disease development Horm Behav 48 2005 1 10 (Pubitemid 40779285)
4. A. Barik, B. Mishra, L. Shen, H. Mohan, R.M. Kadam, and S. Dutta Evaluation of a new copper(II)-curcumin complex as superoxide dismutase mimic and its free radical reactions Free Radic Biol Med 39 2005 811 822 (Pubitemid 41139894)
5. A. Barik, B. Mishra, A. Kunwar, R.M. Kadam, L. Shen, and S. Dutta Comparative study of copper(II)-curcumin complexes as superoxide dismutase mimics and free radical scavengers Eur J Med Chem 42 2007 431 439 (Pubitemid 46517793)
6. I.V. Belozertseva, T. Kos, P. Popik, W. Danysz, and A.Y. Bespalov Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests Eur Neuropsychopharmacol 17 2007 172 179 (Pubitemid 44779190)
7. L. Bravo, G. Escolar, C. Navarro, R. Fontamau, and O. Bulbena Effect of zinc acexamate on gastric lesions induced by aspirin: a morphological study Eur J Pharmacol 190 1990 59 65 (Pubitemid 20372308)
8. R. Cannali, F. Vignolini, F. Nobili, and E. Mengheri Reduction of oxidative stress and cytokine-induced neutrophil chemoattractant (CINC) expression by red wine polyphenols in zinc deficiency induced intestinal damage of rat Free Radic Biol Med 28 2000 1661 1670 (Pubitemid 30628470)
9. D. Carbajal, Y. Ravelo, V. Molina, R. Mas, and M.L. Arruzazabala D-004, a lipid extract from royal palm fruit, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice Pharmacol Biochem Behav 92 2009 465 468
10. A. Chakraborti, K. Gulati, B.D. Banerjee, and A. Ray Possible involvement of free radicals in the differential neurobehavioral responses to stress in male and female rats Behav Brain Res 179 2007 321 325 (Pubitemid 46497464)
11. I. Chattopadhyay, U. Bandyopadhyay, K. Biswas, P. Maity, and R.K. Banerjee Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen Free Radic Biol Med 40 2006 1397 1408
12. C.H. Cho, C.J. Pfeiffer, and A. Cheema Studies of zinc and histamine on lysosomal fragility: possible role in stress ulceration Pharmacol Biochem Behav 13 1980 41 44 (Pubitemid 10009101)
13. C.H. Cho, L.Y.Y. Fong, P.C.C. Ma, and C.W. Ogle Zinc deficiency: its role in gastric secretion and stress-induced gastric ulceration in rats Pharmacol Biochem Behav 26 1987 293 297 (Pubitemid 17038111)
14. K. Cieslik, B. Klenk-Majewska, Z. Danilczuk, A. Wrobel, T. Lupina, and G. Ossowska Influence of zinc supplementation on imipramine effect in a chronic unpredictable stress (CUS) model in rats Pharmacol Rep 59 2007 46 52 (Pubitemid 46522701)
15. M.P. Cunha, D.G. Machado, L.E. Bettio, J.C. Capra, and A.L. Rodrigues Interaction of zinc with antidepressants in the tail suspension test Prog Neuropsychopharmacol Biol Psychiatry 32 2008 1913 1920
16. J.B. Dekanski, A. Macdonald, and P. Sacra Effects of fasting, stress and drugs on gastric glycoprotein synthesis in the rat Br J Pharmacol 55 1975 387 392
17. S. Demirbilek, I. Gurses, N. Sezgin, A. Karaman, and N. Gurbuz Protective effect of polyunsaturated phosphatidylcholind pretreatment on stress ulcer formation in rats J Pediatr Surg 39 2004 57 62 (Pubitemid 38049837)
18. H. Esterbauer, R.J. Shauer, and H. Zollner Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radic Biol Med 11 1991 81 128 (Pubitemid 121003917)
19. N.N. Gomez, R.C. Davicino, V.S. Biaggio, G.A. Bianco, S.M. Alvarez, and P. Fischer Overexpression of inducible nitric oxide synthase and cyclooxygenase-2 in rat zinc-deficient lung: involvement of a NF-κB dependent pathway Nitric Oxide 14 2006 30 38 (Pubitemid 43063505)
20. M. Guldahl The effect of trimipramine (Surmontil r) on masked depression in patients with duodenal ulcer. A double-blind study Scand J Gastroenterol Suppl 43 1977 27 31
21. T. Hatayama, Y. Asai, T. Wakatsuki, T. Kitamura, and H. Imahara Regulation of hsp70 synthesis induced by cupric sulfate and zinc sulfate in thermotolerant HeLa cells J Biochem 114 1993 592 597 (Pubitemid 23311489)
22. C.R. Hung, and P.S. Wang Gastric oxidative stress and hemorrhagic ulcer in Salmonella typhimurium-infected rats Eur J Pharmacol 491 2004 61 68 (Pubitemid 38501776)
23. S. Ikeyama, K. Kusumoto, H. Miyake, K. Rokutan, and S. Tashiro A non-toxic heat shock protein 70 inducer, geranylgeranylacetone, suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol J Hepatol 35 2001 53 61 (Pubitemid 32646224)
24. T. Kawai, S. Teshima, K. Kusumoto, T. Kawahara, K. Kondo, and K. Kishi A non-toxic heat shock protein 70 inducer, geranyl-geranyl-acetone, restores the heat shock response in gastric mucosa of protein-malnourished rats J Lab Clin Med 136 2000 138 148
25. P.C. Konturek, T. Brozozowski, J. Kania, S.J. Konturek, S. Kwiecien, and R. Pajdo Pioglitazone, a specific ligand of peroxisome proliferators-activated receptor gamma, accelerates gastric ulcer healing in rats Eur J Pharmacol 472 2003 213 220 (Pubitemid 37271918)
26. S.K. Kulkarni, M.K. Bhutani, and M. Bishnoi Antidepressant activity of curcumin: involvement of serotonin and dopamine system Psychopharmacology 201 2008 435 442
27. 2A receptors in the antidepressant-like effect of zinc in the forced swimming test Prog Neuropsychopharmacol Biol Psychiatry 32 2008 994 999 (Pubitemid 351609235)
28. G. Lucca, C.M. Comim, S.S. Valvassori, G.Z. Réus, F. Vuolo, and F. Petronilho Effects of chronic mild stress on the oxidative parameters in the rat brain Neurochem Int 54 2009 358 362
29. G. Lucca, C.M. Comim, S.S. Valvassori, G.Z. Réus, F. Vuolo, and F. Petronilho Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm J Psychiatr Res 43 2009 864 869
30. S. Mahattanadul, T. Nakamura, P. Panichayupakaranant, N. Phdoongsombut, K. Tungsinmunkong, and P. Bouking Comparative antiulcer effect of Bisdemethoxycurcumin and Curcumin in a gastric ulcer model system Phytomedicine 16 2009 342 351
31. X.T. Mei, X.J. Luo, S.K. Xu, D.H. Xu, Y.P. Zheng, and S.B. Xu Gastroprotective effects of a new zinc(II)-curcumin complex against pylorus-ligature-induced gastric ulcer in rats Chem Biol Interact 181 2009 316 321
32. K. Mohammadi, K.H. Thompson, B.O. Patrick, T. Storr, C. Martins, and E.G. Polishchuk Synthesis and characterization of dual function vanadyl, gallium and indium curcumin complexes for medicinal applications J Inorg Biochem 99 11 2005 2217 2225 (Pubitemid 41562860)
33. O. Nakagawasai, T. Tadano, Y. Arai, S. Hozumo, A. Oba, and K. Tan-no Enhancement of 5-hydroxytryptamine-induced head-twitch response after olfactory bulbectomy Neuroscience 117 2003 1017 1023 (Pubitemid 36332319)
34. G. Nowak, M. Siwek, D. Dudek, A. Zieba, and A. Pilc Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study Pol J Pharmacol 55 2003 1143 1144
35. H. Oda, H. Miyake, T. Iwata, K. Kusumoto, K. Rokutan, and S. Tashiro Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats J Gastrointest Surg 6 2002 464 473 (Pubitemid 40433553)
36. M. Odashima, M. Otaka, M. Jin, I. Wada, Y. Horikawa, and T. Matsuhashi Zinc l-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-κB activation Life Sci 79 2006 2245 2250 (Pubitemid 44666062)
37. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxide in animal tissues by thiobarbutiric acid reaction Anal Biochem 95 1979 351 358 (Pubitemid 9194347)
38. R.D. Porsolt, G. Anton, M. Deniel, and M. Jalfre Behavioral despair in rats: a new animal model sensitive to antidepressant treatments Eur J Pharmacol 47 1978 379 391
39. A. Putics, D. Vodros, M. Malavolta, E. Mocchegiani, P. Csermely, and C. Soti Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes Exp Gerontol 43 2008 452 461
40. P.N. Ravindran, K.N. Babu, and K. Sivaraman Turmeric the genus Curcuma: the golden spice of life 2007 CRC Press 1 13
41. +-ATPase activity by flavonoids, coumarins and xanthones from Mexican medicinal plants J Ethnopharmacol 105 2006 167 172
42. A.O. Rosa, J. Lin, J.B. Calixto, A.R. Santos, and A.L. Rodrigues Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice Behav Brain Res 144 2003 87 93 (Pubitemid 37011169)
43. K. Sairam, Ch.V. Rao, M.D. Babu, K.V. Kumar, V.K. Agrawal, and R.K. Goel Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study J Ethnopharmacol 82 2002 1 9
44. A.S. Salim Protection against stress-induced acute gastric mucosal injury by free radical scavengers Intensive Care Med 17 1991 455 460
45. S. Sevgi, M. Ozek, and L. Eroglu L-NAME prevents anxiety-like and depression-like behavior in rats exposed to restraint stress Methods Find Exp Clin Pharmacol 28 2006 95 99
46. K.K. Sharma, S. Chandra, and D.K. Basu Synthesis and antiarthritic study of a new orally active diferuloyl methane (curcumin) gold complex Inorg Chim Acta 135 1987 47 48
47. H. Suleyman, E. Cadirci, A. Albayrak, B. Polat, Z. Halici, and F. Koc Comparative study on the gastroprotective potential of some antidepressants in indomethacin-induced ulcer in rats Chem Biol Interact 180 2009 318 324
48. Y. Sun, L.W. Oberley, and Y. Li A simple method for clinical assay of superoxide dismutase Clin Chem 34 1988 497 500
49. B. Szewczyk, E. Poleszak, M. Sowa-Kucma, M. Siwek, D. Dudek, and B. Ryszewska-Pokrasniewicz Antidepressant activity of zinc and magnesiumin view of the current hypotheses of antidepressant action Pharmacol Rep 60 2008 588 599
50. B. Szewczyk, E. Poleszak, P. Wlaz, A. Wrobel, E. Blicharska, and A. Cichy The involvement of serotonergic system in antidepressant effect of zinc in the forced swim test Prog Neuropsychopharmacol Biol Psychiatry 33 2009 323 329
51. R. Tandon, H.D. Khanna, M. Dorababu, and R.K. Goel Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma Indian J Physiol Pharmacol 48 2004 115 118 (Pubitemid 38044296)
52. K.H. Thompson, K. Böhmerle, E. Polishchuk, C. Martins, P. Toleikis, and J. Tse Complementary inhibition of synoviocyte, smooth muscle cell or mouse lymphoma cell proliferation by a vanadyl curcumin complex compared to curcumin alone J Inorg Biochem 98 2004 2063 2070 (Pubitemid 39489898)
53. M. Tuorkey, and K. Karolin Antiulcer activity of curcumin onexperimental gastric ulcer in rats and its effect on oxidative stress/antioxidant, IL6 and enzyme activities Biomed Environ Sci 22 2009 488 495
54. O. Vajragupta, P. Boonchoong, H. Watanabe, M. Tohda, N. Kammasud, and Y. Sumanont Manganese complexes of curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity Free Radic Biol Med 35 2003 1632 1644 (Pubitemid 37532914)
55. J. Varghese, M. Faith, and M. Jacob Zinc prevents indomethacin-induced renal damage in rats by ameliorating oxidative stress and mitochondrial dysfunction Eur J Pharmacol 614 2009 114 121
56. I. Wada, M. Otaka, M. Jin, M. Odashima, K. Komatsu, and N. Konishi Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection Biochem Biophys Res Commun 349 2006 615 617
57. N. Whittle, G. Lubec, and N. Singewald Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in mice Amino Acids 36 2009 147 158
58. Y. Xu, B.S. Ku, H.Y. Yao, Y.H. Lin, X. Ma, and Y.H. Zhang Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats Pharmacol Biochem Behav 82 2005 200 206 (Pubitemid 41423504)
59. J. Yamaoka, T. Kume, A. Akaike, and Y. Miyachi Suppressive effect of zinc ion on iNOS expression induced by interferon-γ or tumor necrosis factor-α in murine keratinocytes J Dermatol Sci 23 2000 27 35 (Pubitemid 30107837)