Gastroprotective effects of a new zinc(II)-curcumin complex against pylorus-ligature-induced gastric ulcer in rats

Chemico-Biological Interactions

Volumn 181, Issue 3, 2009, Pages 316-321

  Mei, Xueting ^a   Luo, Xiaoju ^a   Xu, Sika ^a   Xu, Donghui ^a   Zheng, Yanping ^a   Xu, Shibo ^a   Lv, Junyi ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Antiulcer; IL 8; NF B; Synergistic effect; TGF 1; Zn(II) curcumin complex

Indexed keywords

ACETIC ACID; CURCUMIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LANSOPRAZOLE; PEPSIN A; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; WATER; ZINC COMPLEX; ZINC CURCUMIN COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN INDUCTION; PYLORUS LIGATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH PH; STOMACH PROTECTION; STOMACH ULCER; STOMACH VOLUME; THERMOGRAVIMETRY; TOXICITY TESTING;

ANIMALS; ANTI-ULCER AGENTS; BASE SEQUENCE; CURCUMIN; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-8; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; NF-KAPPA B; ORGANOMETALLIC COMPOUNDS; PYLORIC ANTRUM; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH ULCER; TRANSFORMING GROWTH FACTOR BETA;

MUS; RATTUS;

EID: 70249126476     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.06.022     Document Type: Article

References (31)

1. Srimal R.C. Turmeric: a brief review of medicinal properties. Fitoterapia 68 (1997) 483-493
2. Anand P., Thomas S.G., Kunnumakkara A.B., Sundaram C., Harikumar K.B., Sung B., Tharakan S.T., Misra K., Priyadarsini I.K., Rajasekharan K.N., and Aggarwal B.B. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem. Pharmacol. 76 (2008) 1590-1611
3. Aggarwal B.B., and Harikumar K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell B 41 (2009) 40-59
4. Reuter S., Eifes S., Dicato M., Aggarwal B.B., and Diederich M. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem. Pharmacol. 76 (2008) 1340-1351
5. Goel A., Kunnumakkara A.B., and Aggarwal B.B. Curcumin as "Curecumin": from kitchen to clinic. Biochem. Pharmacol. 75 (2008) 787-809
6. Zaidi S.F.H., Yamada K., Kadowaki M., Usmanghani K., and Sugiyama T. Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori. J. Ethnopharmacol. 121 (2009) 286-291
7. Aggarwal B.B., Kumar A., and Bharti A.C. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 23 (2003) 363-398
8. Tonnesen H.H., Masson M., and Loftsson T. Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int. J. Pharm. 244 (2002) 127-135
9. Yang K.Y., Lin L.C., Tseng T.Y., Wang S.C., and Tsai T.H. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 853 (2007) 183-189
10. Xu D.H., Wang S., Jin J., Mei X.T., and Xu S.B. Dissolution and absorption researches of curcumin in solid dispersions with the polymers PVP. Asian J. Pharmacodyn. Pharmacokinet. 6 (2006) 343-349
11. Jiao Y., Wilkinson IV J., Pietsch E.C., Buss J.L., Wang W., Planalp R., Torti F.M., and Torti S.V. Iron chelation in the biological activity of curcumin. Free Radic. Bio. Med. 40 (2006) 1152-1160
12. Barik A., Mishra B., Kunwar A., Kadam R.M., Shen L., Dutta S., Padhye S., Satpati A.K., Zhang H.Y., and Priyadarsini K.I. Comparative study of copper (II)-curcumin complexes as superoxide dismutase mimics and free radical scavengers. Eur. J. Med. Chem. 42 (2007) 431-439
13. Vajragupta O., Boonchoong P., Watanabe H., Tohda M., Kummasud N., and Sumanont Y. Manganese complexes of curcumin and its derivatives: evaluation for the radical scavenging ability and neuroprotective activity. Free Radic. Bio. Med. 359 (2003) 1632-1644
14. Sharma K.K., Chandra S., and Basu D.K. Synthesis and antiarthritic study of a new orally active diferuloyl methane (curcumin) gold complex. Inorg. Chim. Acta 135 (1987) 47-48
15. Faa G., Nurchi V.M., Ravarino A., Fanni D., Nemolato S., Gerosa C., Eyken P.V., and Geboes K. Zinc in gastrointestinal and liver disease. Coordin. Chem. Rev. 252 (2008) 1257-1269
16. Odashima M., Otaka M., Jin M., Wada I., Horikawa Y., Matsuhashi T., Ohba R., Hatakeyama N., Oyake J., and Watanabe S. Zinc l-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-κB activation. Life Sci. 79 (2006) 2245-2250
17. Singla A.K., and Wadhwa H. Zinc-indomethacin complex: synthesis, physicochemical and biological evaluation in the rat. Int. J. Pharm. 120 (1995) 145-155
18. Sharma J., Singla A.K., and Dhawan S. Zinc-naproxen complex: synthesis, physicochemical and biological evaluation. Int. J. Pharm. 260 (2003) 217-227
19. Biswas K., Bandyopadhyay U., Chattopadhyay I., Varadaraj A., Ali E., and Banerjee R.K. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J. Biol. Chem. 278 (2003) 10993-11001
20. Shay H., Komarov S.A., Fels S.S., Meranze D., Gruenstein M., and Siplet H. A simple method for the uniform production of gastric ulceration. Gastroenterology 5 (1945) 43-61
21. Souza Brito A.R.M. Manual De Ensaios Toxicológicos In Vivo (1994), Editora Unicamp, Campinas pp. 11-15
22. Takahashi S., Fujita T., and Yamamoto A. Role of nuclear factor-κB in gastric ulcer healing in rats. Am. J. Physiol. 280 (2001) 1296-1304
23. Perkins N.D., and Gilmore T.D. Good cop, bad cop: the different faces of NF-kappaB. Cell Death Differ. 13 (2006) 759-772
24. Takeuchi T., Miura S., Wang L., Uehara K., Mizumori M., Kishikawa H., Hokari R., Higuchi H., Adachi M., Nakamizo H., and Ishii H. Nuclear factor-kappaB and TNF-alpha mediate gastric ulceration induced by phorbol myristate acetate. Dig. Dis. Sci. 47 (2002) 20070-20078
25. Tominaga K., Arakawa T., Kim S., Iwao H., and Kobayashi K. Acceleration of wound healing in gastric ulcers by local injection of neutralising antibody to transforming growth factor beta1. Dig. Dis. Sci. 42 (1997) 616-625
26. Uzzo R.G., Crispen P.L., Golovine K., Makhov P., Horwitz E.M., and Kolenko V.M. Diverse effects of zinc on NF-κB and AP-1 transcription factors: implications for prostate cancer progression. Carcinogenesis 27 (2006) 1980-1990
27. Bao B., Prasad A., Beck F.W., Suneja A., and Sarkar F. Toxic effect of zinc on NF-κB, IL-2, IL-2 receptor α, and TNF-α in HUT-78 (Th0) cells. Toxicol. Lett. 166 3 (2006) 222-228
28. Rikki S.C., Tassabehji N.M., Hare J., Sharma G., and Levensona C.W. Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms. Brain Res. 1237 27 (2008) 52-61
29. Bao B., Prasad A.S., Beck F.W.J., Snell D., Suneja A., Sarkar F.H., Doshi N., Fitzgerald J.T., and Swerdlow P. Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients. Transl. Res. 152 (2008) 67-80
30. Gaedeke J., Noble N.A., and Border W.A. Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells. Kidney Int. 66 (2004) 112-120
31. Mahattanadul S., Nakamura T., Panichayupakaranant P., Phdoongsombut N., Tungsinmunkong K., and Bouking P. Comparative antiulcer effect of Bisdemethoxycurcumin and Curcumin in a gastric ulcer model system. Phytomedicine 16 (2009) 342-351