A non-toxic heat-shock protein 70 inducer, geranyl-geranyl-acetone, restores the heat shock response in gastric mucosa of protein-malnourished rats

Journal of Laboratory and Clinical Medicine

Volumn 136, Issue 2, 2000, Pages 138-148

  Kawai, Tomoko ^a   Teshima, Shigetada ^a   Kusumoto, Kenji ^a   Kawahara, Tsukasa ^a   Kondo, Kazumi ^a   Kishi, Kyoichi ^a   Rokutan, Kazuhito ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033796433     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1067/mlc.2000.108157     Document Type: Article

References (42)

1. The heat shock response
2. Chaperone-mediated protein folding
3. Mammalian stress response: Cell physiology, structure/function of stress protein, and implications for medicine and disease
4. Clinical implications of the stress response
5. Pathophysiologic changes in the critically ill patient: Risk factors for ulceration and altered drug metabolism
6. Circulatory factors in gastric mucosal defense and repair
7. Prophylactic therapy for stress ulcer bleeding: A reappraisal
8. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa
9. Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1
10. Alteration of the respiratory burst and phagocytosis of macrophages under protein malnutrition
11. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells
12. Glutathione depletion impairs transcriptional activation of heat shock genes in primary cultures of guinea pig gastric mucosal cells
13. Molecular cloning and expression of a human heat shock factor, HSF1
14. Cloning characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability
15. Isolation of a cDNA for HSF2: Evidence for two heat shock factor genes in humans
16. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway
17. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator
18. Transcriptional regulation of heat shock genes
19. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription
20. Protein traffic on the heat shock promotor: Parking, stalling, and tracking along
21. Heat shock transcription factors: Structure and regulation
22. Intramolecular repression of mouse heat shock factor 1
23. Salicylate triggers heat shock factor differently than heat
24. The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive
25. Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation: Evidence for a multistep pathway of regulation
26. Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone
27. Increasing action of teprenone, a new antiulcer agent, on high-molecular-weight glycoprotein in gastric mucus during the healing process of acetic acid-induced ulcer in rats
28. Effect of teprenone on the content of phospholipids in gastric secretion in man
29. Effects of antiulcer drugs on phosphatidylcholine synthesis in isolated guinea pig gastric glands
30. Increase in lipid peroxidation in rat gastric mucosal lesions induced by water-immersion restraint stress
31. Changes in gastric mucosal content of adenosine, xanthine and hypoxanthine induced by restrained water immersion stress: Antiulcer effects of tetraprenylacetone
32. Involvement of the xanthine-xanthine oxidase system and neutrophiles in the development of acute gastric mucosal lesions in rats with water immersion restraint stress
33. Protective and preventive effects of teprenone on gastric mucosal lesions in rats
34. Mitochondria are selective targets for the protective effects of heat shock against oxidative injury
35. Protective effects of hsp70 in inflammation
36. Apoptosis of Ewing's sarcoma cells is accompanied by accumulation of ubiquitinated proteins
37. Role of human heat shock protein hsp70 in protection against stress-induced apoptosis
38. HSP70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance
39. Heat shock protein 72 modulates pathways of stress-induced apoptosis
40. Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells
41. Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects