Mucuna pruriens Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats

Indian Journal of Experimental Biology

Volumn 49, Issue 4, 2011, Pages 254-259

  Fung, Shin Yee ^a   Tan, Nget Hong ^a   Sim, Si Mui ^a   Marinello, Enrico ^a,b   Guerranti, Roberto ^a,b   Aguiyi, John Chinyere ^a,c  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF JOS   (Nigeria)

Author keywords

Antivenom effects; Immunology; Mucuna pruriens seed; Naja sputatrix venom

Indexed keywords

PLANT EXTRACT; SNAKE VENOM;

AFRICAN MEDICINE; ANIMAL; ARTICLE; CARDIOVASCULAR SYSTEM; CHEMICAL PHENOMENA; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; MALE; MEDICINAL PLANT; MUCUNA; NERVOUS SYSTEM; NIGERIA; PHYTOTHERAPY; PLANT SEED; RAT; RESPIRATORY SYSTEM; SPRAGUE DAWLEY RAT;

ANIMALS; CARDIOVASCULAR SYSTEM; COBRA VENOMS; DEPRESSION, CHEMICAL; MALE; MEDICINE, AFRICAN TRADITIONAL; MUCUNA; NERVOUS SYSTEM; NIGERIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY SYSTEM; SEEDS;

MUCUNA; MUCUNA PRURIENS; NAJA NIGRICOLLIS; NAJA SPUTATRIX; RATTUS;

EID: 79955427403     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Soares A M, Ticli F K, Marcussi S, Lourenco M V, Januario A H, Sampaio S V, Giglio J R, Lomonte B & Pereira P S, Medicinal plants with inhibitory properties against snake venoms, Curr Med Chem, 12 (2005) 2625.
2. Owuor B O & Kisangau D P, Kenyan medicinal plants used as antivenin: A comparison of plant usage, J Ethnobiol Ethnomed, 2 (2006) 7.
3. Mors W B, Plants active against snake bite, Mem Inst Oswaldo Cruz, 86 Suppl 2 (1991) 193.
4. Sathiyanarayanan L & Arulmozhi S, Mucuna pruriens Linn.-A comprehensive review, Pharmacognosy Rev, 1 (2007) 157.
5. Aguiyi J C, Igweh A C, Egesie U G & Leoncini R, Studies on possible protection against snake venom using Mucuna pruriens protein immunization, Fitoterapia, 70 (1999) 21.
6. Guerranti R, Aguiyi J C, Neri S, Leoncini R, Pagani R & Marinello E, Proteins from Mucuna pruriens and enzymes from Echis carinatus venom: Characterization and crossreactions, J Biol Chem, 277 (2002) 17072.
7. Tan N H, The biochemistry of venoms of some venomous snakes of Malaysia-A review, Tropical Biomed, 8 (1991) 91.
8. Tan N H, Fung S Y, Sim S M, Marinello E, Guerranti R & Aguiyi J C, The protective effect of Mucuna pruriens seed against cobra venom poisoning: Immunological studies, FEBS J, 275 (2008) 432.
9. Guerranti R, Aguiyi J C, Ogueli I G, Onorati G, Neri S, Rosati F, Del Buono F, Rampariello R, Pagani R & Marinello E, Protection of Mucuna pruriens seeds against Echis carinatus venom is exerted through a multiform glycoprotein whose oligosaccharide chains are functional in this role, Biochem Biophys Res Commun, 323 (2004) 484.
10. Howard-Jones N, A CIOMS ethical code for animal experimentation. WHO Chron, 39 (1985) 51.
11. Aguiyi J C, Guerranti R, Pagani R & Marinello E, Blood chemistry of rats pretreated with Mucuna pruriens seed aqueous extract MP101UJ after Echis carinatus venom challenge, Phytother Res, 15 (2001) 712.
12. Tan N H, Fung S Y, Sim S M, Marinello E, Guerranti R & Aguiyi J C, The protective effect of Mucuna pruriens seeds against snake venom poisoning, J Ethnopharmacol, 123 (2009) 356.
13. Guerranti R, Aguiyi J C, Errico E, Pagani R & Marinello E, Effects of Mucuna pruriens extract on activation of prothrombin by Echis carinatus venom, J Ethnopharmacol, 75 (2001) 175.
14. Guerranti R, Ogueli I G, Bertocci Y, Muzzi C, Aguiyi J C, Cianti R, Armini A, Bini L, Leoncini R, Marinello E & Pagani R, Proteomics analysis of the pathophysiological process involved in the antisnake venom effect of Mucuna pruriens extract, Proteomics, 8 (2008) 402.
15. Fung S Y, Tan N H, Liew S H, Sim S M & Aguiyi J C, The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats, Tropical Biomedicine, 26 (2009) 80.
16. Geh S L, The neuromuscular and cardiovascular effects of the venoms of Naja naja sputatrix, Naja naja kaouthia and Ophiophagus hannah, three cobras indigenous to Malaysia, Asia Pacific J Pharmacol, 8 (1993) 37.
17. Lee C Y, Chang C C, Chiu T H, Tseng T C & Lee S Y, Pharmacological Properties of Cardiotoxin Isolated from Formosan Cobra Venom. Naunyn-Schmiedebergs Arch. Pharmak. u. exp. Path, 259 (1968) 360.
18. 2 from Naja nigricollis venom? Acta Physiol Pharmacol Latinoam, 39 (1989) 383.
19. 2 isolated from Malayan cobra (Naja naja sputatrix) venom, Toxicon, 28 (1990) 1193.
20. Fung S Y, Tan N H & Sim S M, Neutralization of lethalities of some snake venoms by antibodies raised against Mucuna pruriens seed extract, paper presented at the Global Issues in Clinical Toxinology Conference, ICT Building, The University of Melbourne, Melbourne, Australia, 23-28 November, 2008 (Abstract No.49).