Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts

Journal of the American College of Cardiology

Volumn 57, Issue 18, 2011, Pages 1846-1855

  Tang, Tong ^a,b   Hammond, H Kirk ^a,b   Firth, Amy ^b   Yang, Yuan ^b   Gao, Mei Hua ^a,b   Yuan, Jason X J ^b   Lai, N Chin ^a,b  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

adenylyl cyclase; calcium uptake; cardiac aging; extracellular matrix remodeling; left ventricular function; transgenic mouse

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 6; ALPHA ACTIN; ATRIAL NATRIURETIC FACTOR; BETA ADRENERGIC RECEPTOR; CALCIUM; CASPASE 3; CASPASE 7; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ELASTIN; FIBRONECTIN; GELATINASE A; ISOPRENALINE; MESSENGER RNA; MYOSIN HEAVY CHAIN BETA; NEUTROPHIL COLLAGENASE; PHOSPHOLAMBAN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN BCL 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RUNX2; TROPONIN I; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE RELAXATION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; TIBIA;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; AGING; ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ECHOCARDIOGRAPHY; ISOPROTERENOL; MICE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITORS; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STROKE VOLUME; TETRACYCLINE; TROPONIN I; VENTRICULAR FUNCTION, LEFT;

EID: 79955419628     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2010.11.052     Document Type: Article

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